Lindsay Fernández‐Rhodes
A5079618257- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Genetic and phenotypic traits in livestock
- Birth, Development, and Health
- Cardiovascular Health and Risk Factors
- Epigenetics and DNA Methylation
- Genetic Mapping and Diversity in Plants and Animals
- Obesity, Physical Activity, Diet
- BRCA gene mutations in cancer
- Health disparities and outcomes
- Nutritional Studies and Diet
- Health, Environment, Cognitive Aging
- RNA Research and Splicing
- Hypothalamic control of reproductive hormones
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Racial and Ethnic Identity Research
- Reproductive Physiology in Livestock
- Ovarian cancer diagnosis and treatment
- Food Security and Health in Diverse Populations
- Neurogenetic and Muscular Disorders Research
- Obesity and Health Practices
- Migration, Health and Trauma
Pennsylvania State University
2017-2025
University of North Carolina at Chapel Hill
2015-2024
University of Puerto Rico at Carolina
2023
Lindsay Unified School District
2019
Public Health Department
2012-2018
National Institutes of Health
2009-2014
National Institute of Neurological Disorders and Stroke
2009-2014
Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by a CAG repeat expansion in the androgen receptor gene. To characterize natural history define outcome measures for clinical trials, we assessed history, laboratory findings muscle strength function 57 patients with genetically confirmed disease. We also administered self-assessment questionnaires activities of daily living, quality life erectile function. found average delay over 5 years from onset weakness to...
Abstract Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women the top bottom 1% polygenic risk exhibited ~11 ~14-fold higher risks delayed precocious puberty, respectively. identified several genes harboring rare loss-of-function variants ~200,000 including ZNF483 , which...
Abstract Objective: Several genome–wide association studies (GWAS) have demonstrated that common genetic variants contribute to obesity. However, of this complex trait focused on ancestrally European populations, despite the high prevalence obesity in some minority groups. Design and Methods: As part “Population Architecture using Genomics Epidemiology (PAGE)” Consortium, we investigated between 13 GWAS‐identified single‐nucleotide polymorphisms (SNPs) BMI 69,775 subjects, including 6,149...
Do genetic associations identified in genome-wide association studies (GWAS) of age at menarche (AM) and natural menopause (ANM) replicate women diverse race/ancestry from the Population Architecture using Genomics Epidemiology (PAGE) Study? We replicated GWAS reproductive trait single nucleotide polymorphisms (SNPs) our European descent population found that many SNPs were also associated with AM ANM populations ancestry. Menarche mark lifespan are important risk factors for chronic...
Several genome-wide studies have identified loci associated with reproductive traits, such as ages of menarche and menopause, in women European ancestry. In this study, we investigated the relevance these minority US Hispanic women. We utilized data from 3468 who were genotyped a part Women's Health Initiative SNP Association Resource. replicated associations eight (LRP18, LIN28B, CENPW, INHBA, TMEM38B, ZNF483, NFAT5 OLFM2) age at menarche, two (MCM8 BRSK1/TMEM150B) menopause. The MCM8 locus...
Polygenic severe obesity (body mass index [BMI] ≥40 kg/m2) has increased, especially in Hispanic/Latino populations, yet we know little about the underlying mechanistic pathways. We analyzed whole-blood multiomics data to identify genes differentially regulated Mexican Americans from Cameron County Hispanic Cohort. Our RNA sequencing analysis identified 124 significantly expressed between cases (BMI and controls <25 kg/m2); 33% replicated an independent sample same population. integrative...
Age at menarche (AM) and age natural menopause (ANM) define the boundaries of reproductive lifespan in women. Their timing is associated with various diseases, including cancer cardiovascular disease. Genome-wide association studies have identified several genetic variants either AM or ANM populations largely European Asian descent The extent to which these associations generalize diverse remains unknown. Therefore, we sought replicate previously reported findings identify novel using...
Summary/Abstract Genome-wide association studies (GWAS) have laid the foundation for investigations into biology of complex traits, drug development, and clinical guidelines. However, dominance European-ancestry populations in GWAS creates a biased view role human variation disease, hinders equitable translation genetic associations public health applications. The Population Architecture using Genomics Epidemiology (PAGE) study conducted 26 behavioral phenotypes 49,839 non-European...
Purpose . The adult myopathy assessment tool (AMAT) is a performance-based battery comprised of functional and endurance subscales that can be completed in approximately 30 minutes without the use specialized equipment. purpose this study was to determine construct validity internal consistency AMAT with sample adults spinal bulbar muscular atrophy (SBMA). Methods assessed 56-male participants genetically confirmed SBMA (mean age, 53 ± 10 years). assessments for disease status, strength,...
Obesity is a public health concern. Yet the identification of adiposity-related genetic variants among United States (US) Hispanics, which largest US minority group, remains largely unknown.To interrogate an priori list 47 (32 overall body mass and 15 central adiposity) index single-nucleotide polymorphisms (SNPs) previously studied in individuals European descent 3494 Hispanic women Women's Health Initiative SNP Association Resource (WHI SHARe).Cross-sectional analysis measured (BMI), waist...