A5109760582- Angiogenesis and VEGF in Cancer
- Extracellular vesicles in disease
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cardiac pacing and defibrillation studies
- Renin-Angiotensin System Studies
- Genetic Associations and Epidemiology
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cardiac Ischemia and Reperfusion
- RNA modifications and cancer
- Hepatitis B Virus Studies
- Recycled Aggregate Concrete Performance
- Cardiac Arrhythmias and Treatments
- Circular RNAs in diseases
- Bioinformatics and Genomic Networks
- Wound Healing and Treatments
- Nerve injury and regeneration
- Peroxisome Proliferator-Activated Receptors
- Nanoplatforms for cancer theranostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Innovative concrete reinforcement materials
- Natural product bioactivities and synthesis
- Pregnancy and preeclampsia studies
- Invertebrate Immune Response Mechanisms
Sichuan Agricultural University
2022-2025
Xi'an Jiaotong University
2024
University of Exeter
2020-2024
Institute of Earth Environment
2024
Chinese Academy of Sciences
2012-2024
Air Force Medical University
2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Wellcome Sanger Institute
2020-2023
Heilongjiang University
2023
Oxidative stress-induced endothelial dysfunction plays a key role in ischemia/reperfusion injury. Recent evidence indicates that progenitor cell-derived microvesicles (EPC-MVs) can promote angiogenesis of cells (ECs). Here, we investigated the potential effects EPC-MVs on hypoxia/reoxygenation (H/R) injury human brain microvascular ECs (hb-ECs). MVs were prepared from EPCs cultured serum deprivation (SD) medium (starving stress, sEPC-MVs) or SD containing tumor necrosis factor- α (TNF )...
Angiotensin-converting enzyme 2 (ACE2) is a lately discovered catalyzing Angiotensin II into 1-7. has been reported to impair endothelial progenitor cell (EPC) function and detrimental stroke. Here, we studied the role of ACE2 in regulating EPC vitro vivo. EPCs were cultured from human renin angiotensinogen transgenic (R+A+) mice their controls (R-A-). In experiments, transduced with lentivirus-ACE2 or lentivirus-green fluorescence protein. The effects overexpression on NO synthase...
For determining the implications of circulating endothelial progenitor cells (cEPCs) and cellular membrane microparticles (MPs) in diabetic stroke, levels EPCs, EPC-MPs, endothelium-derived MPs (EMPs) their correlations with blood glucose concentration, cerebral microvascular density (cMVD), ischemic damage were investigated type 2 db/db db/+ (wild-type control) mice. Therapeutic efficacy EPC infusion (preincubated MPs) was also explored. Ischemic stroke induced by middle artery occlusion...
Cell-released microvesicles (MVs) represent a novel way of cell-to-cell communication. Previous evidence indicates that endothelial progenitor cells (EPCs)-derived MVs can modulate cell survival and proliferation. In this study, we evaluated whether EPC-MVs protect cardiomyocytes (CMs) against angiotensin II (Ang II)-induced hypertrophy apoptosis. The H9c2 CMs were exposed to Ang in the presence or absence EPC-MVs. Cell viability, apoptosis, surface area β-myosin heavy chain (β-MHC)...
The digestive system is gaining interest as a major regulator of various functions including immune defense, nutrient accumulation, and regulation feeding behavior, aside from its conventional function organ. Drosophila midgut epithelium completely renewed every 1-2 weeks due to differentiation pluripotent intestinal stem cells in the midgut. Intestinal constantly divide differentiate into enterocytes that secrete enzymes absorb nutrients, or enteroendocrine regulatory peptides. Regulatory...
In recent years, the first-line anti-diabetic drug metformin has been shown to be also useful for treatment of other diseases like cancer. To date, few reports were about impact on gut microbiota. fully understand mechanism action in treating than diabetes, it is especially important investigate long-term microbiome non-diabetic status. this study, we treated healthy mice with 30 days, and observed 46 significantly changed microbes by using 16S rRNA-based profiling technique. We found that...
Summary Aims To examine whether transplantation of adipose‐derived stem cells ( ADSC s) induces neural differentiation and improves function in a rat intracerebral hemorrhage ICH ) model. Methods Adipose‐derived were isolated from inguinal fat pad rat. was induced by injection collagenase type IV into the right basal ganglia Forty‐eight hours after , s (10 μL 2–4 × 10 7 cells/ mL injected lateral cerebral ventricle. The detected vitro vivo . evaluated with Z ea L onga 5‐grade scale at day 1,...
This study investigated the role of stromal cell-derived factor-1α (SDF-1α)/CXC chemokine receptor 4 (CXCR4) axis in brain and endothelial progenitor cells (EPCs), explored efficacy CXCR4 primed EPCs treating ischemic stroke diabetes. The db/db diabetic db/+ mice were used this study. Levels plasma SDF-1α circulating CD34+CXCR4+ measured. Brain expression quantified at basal after middle cerebral artery occlusion (MCAO). In vitro study, transfected with adenovirus carrying null (Ad-null) or...
This study explores the effect of citicoline on permeability and expression tight junction proteins (TJPs) in endothelial cells under hypoxia/aglycemia conditions. Hypoxia or oxygen glucose deprivation (OGD) was utilized to induce barrier breakdown model human umbilical vein (HUVECs) mouse brain microvascular (bEnd.3s). The models determined at either low high concentrations. FITC-Dextran flux used examine permeability. TJPs measured by immunofluorescence, Real-time PCR Western Blot methods....
In this study, quantitative structure-activity relationship (QSAR) models were determined based on 91 antioxidant tripeptides. We firstly adopted the stepwise regression (SWR) method for selecting key variables without autocorrelation and then utilized multiple linear (MLR), support vector machine (SVM), random forest (RF), partial least square (PLS) to develop predictive QSAR screened variables. The results demonstrated that all established have good reliability (R²train > 0.86, Q²train...
The rapid development of industrialization, urbanization, and population the society augments rising amount municipal solid waste (MSW). With advantage considerably reducing mass volume wastes generating energy, incineration is a widely used treatment method for MSW. During process, organic substances contained in are combusted, massive residues remained. Of residues, bottom ash takes up to 80–90%, remainders fly along with air pollution control residues. Dealing (MSWI) sustainable manner...
Abstract Harbinger transposase‐derived 1 proteins (HARBI1s) play important roles in plant growth, development, and response to abiotic stress. OsHARBI1‐1 has been identified as a gene encoding HARBI1‐1 protein rice shown be responsive Cadmium (Cd) However, the function of under heavy metal stress remains unclear. In this study, novel Cd‐responsive gene, OsHARBI1‐1, Cd was characterized by heterologous expression yeast. The conferred yeast with increased tolerance Cd. addition, cells...
FAM3A is a novel mitochondrial protein, and its biological function remains largely unknown. This study determined the role mechanism of in liver ischemia-reperfusion injury (IRI). In mouse after IRI, expression was increased. FAM3A-deficient mice exhibited exaggerated damage with increased serum levels AST, ALT, MPO, MDA oxidative stress when compared WT IRI. livers had decrease ATP content, Akt activity anti-apoptotic protein an increase apoptotic expression, inflammation Rosiglitazone...
Obesity rates have nearly tripled in the past 50 years, and by 2030 more than 1 billion individuals worldwide are projected to be obese. This creates a significant economic strain due associated non-communicable diseases. The root cause is an energy expenditure imbalance, owing interplay of lifestyle, environmental, genetic factors. has polygenic architecture; however, single variants with large effect size etiological minority cases. These allowed discovery novel genes biology relevant...
ABSTRACT We assembled an ancestrally diverse collection of genome-wide association studies type 2 diabetes (T2D) in 180,834 cases and 1,159,055 controls (48.9% non-European descent). identified 277 loci at significance ( p <5×10 -8 ), including 237 attaining a more stringent trans-ancestry threshold -9 which were delineated to 338 distinct signals. Trans-ancestry meta-regression offered substantial enhancements fine-mapping, with 58.6% associations precisely localised due population...
Osteosarcoma is a malignant tumor with high mortality in children and adolescents. The mechanism of osteosarcoma metastasis currently unclear. Abnormal expression long non-coding RNA (lncRNA) plays an important role metastasis. We used bioinformatics to analyze the differences gene between situ lung metastases. CCK-8 was detect effect lncRNA LOC100129620 on proliferation cells. invasion cells assessed by Transwell assay. regulatory miR-335-3p examined using pull-down luciferase reporter...
Neuropathic pain is a type of chronic induced by either central or peripheral nerve injury. MicroRNAs have been recently linked to many diseases, including neuropathic pain. However, the role miR-7a in still remains elusive. Thus, we aim investigate effects on based spinal ligation rat model. After establishment models, rats were infected with adeno-associated virus-neurofilament light polypeptide, virus-miR-7a treated metformin. The paw withdrawal threshold and latency assessed afterward,...