A5100613816- Mesenchymal stem cell research
- Tissue Engineering and Regenerative Medicine
- Neurogenesis and neuroplasticity mechanisms
- Hematopoietic Stem Cell Transplantation
- Osteoarthritis Treatment and Mechanisms
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- Cellular transport and secretion
- Photosynthetic Processes and Mechanisms
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Photoreceptor and optogenetics research
- Neonatal Respiratory Health Research
- Advanced Computing and Algorithms
- Traditional Chinese Medicine Studies
- Glioma Diagnosis and Treatment
- Cardiac Fibrosis and Remodeling
- Cardiac Ischemia and Reperfusion
- Circular RNAs in diseases
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- CAR-T cell therapy research
- Corneal Surgery and Treatments
Huazhong University of Science and Technology
2012-2025
Nanjing Drum Tower Hospital
2021
Kyushu University
2021
Chinese PLA General Hospital
2019
PLA Navy General Hospital
2018
Capital Medical University
2016-2018
Beijing Obstetrics and Gynecology Hospital
2018
Southern Medical University
2018
Nanfang Hospital
2018
Wenzhou Medical University
2017
The balance between synaptic excitation and inhibition (E/I) is essential for coordinating motor behavior, yet the differential roles of exocytosis regulators in this are less understood. In study, we investigated 2 conserved regulators, complexin/CPX-1 CAPS/UNC-31, excitatory versus inhibitory synapses at Caenorhabditis elegans neuromuscular junctions. cpx-1 null mutants exhibited a marked increase spontaneous release specifically synapses, alongside an unequal reduction evoked release. A...
Heterogeneity of mesenchymal stem cells (MSCs) influences the cell therapy outcome and application in tissue engineering.Also, subpopulations MSCs cartilage regeneration remains poorly characterized.CD146+ are identified as natural ancestors expression CD146 indicative greater pluripotency self-renewal potential.Here, we sorted a + subpopulation from adipose-derived (ADSCs) for regeneration.Methods: ADSCs were using magnetic activated sorting (MACS).Cell surface markers, viability, apoptosis...
Summary Aims To examine whether transplantation of adipose‐derived stem cells ( ADSC s) induces neural differentiation and improves function in a rat intracerebral hemorrhage ICH ) model. Methods Adipose‐derived were isolated from inguinal fat pad rat. was induced by injection collagenase type IV into the right basal ganglia Forty‐eight hours after , s (10 μL 2–4 × 10 7 cells/ mL injected lateral cerebral ventricle. The detected vitro vivo . evaluated with Z ea L onga 5‐grade scale at day 1,...
Mesenchymal stem cells (MSCs) have attracted great interest for cell therapy and tissue regeneration due to their self-renewal capacity, multipotency potent immunomodulatory effects on immune cells. However, heterogeneity of MSCs has become a prominent obstacle limit translation into practice, as from different sources or each individual differences in transcriptomic signatures, differentiation potential biological functions. Therefore, there is an urgent need consensus standard the quality...
Articular cartilage injury and defect caused by trauma chronic osteoarthritis vascularity are very common, while the repair of injured remains a great challenge due to its limited healing capacity. Stem cell-based tissue engineering provides promising treatment option for articular because cells potential multiple differentiations. However, application has been largely stem cell type, number, source, proliferation, differentiation. We hypothesized that (1) adipose-derived ideal seed their...
Cranial radiotherapy is common in pediatric oncology. Our purpose was to investigate if irradiation (IR) the immature brain would increase susceptibility hypoxic-ischemic injury adulthood. The left hemisphere of postnatal day 10 (P10) mice irradiated with 8 Gy and subjected hypoxia-ischemia (HI) on P60. Brain injury, neurogenesis inflammation were evaluated 30 days after HI. IR alone caused significant hemispheric tissue loss, or lack growth (2.8 +/- 0.42 mm(3), p < 0.001). Tissue loss HI...
Adipose-derived mesenchymal stem cell (ADMSC) therapy can promote recovery from cerebral ischemia; however, more information regarding appropriate sources of ADMSCs is required. This study was aimed at analyzing the immunogenicity rat by comparing immunological effects intraparenchymal administration allogeneic (allo-ADMSCs) and autologous (auto-ADMSCs) after acute phase middle artery occlusion (MCAO) in rats.Allo- or auto-ADMSCs rats (1 × 106 cells) were transplanted into Lewis 8 days post...
Abstract The purpose of this study was to investigate the feasibility adipose‐derived stem cells (ADSCs) as seed cartilage tissue engineering. ADSCs were isolated from adipose that harvested under sterile conditions inguen fold porcines and cultured in vitro. Acellular extracellular matrix (ACECM) scaffolds pigs then constructed. Moreover, inflammatory cells, well cellular humoral immune responses, detected using hematoxylin eosin staining staining, immunohistochemical western blot analysis....
Objective To investigate whether human bone marrow mesenchymal stem cells (hBC-MSCs) have the immune-suppression ability on proliferation of peripheral blood mononuclear (PBMCs) and their pro-inflammatory cytokine production in rats, to explore what kinds cytokines are required for induction hBM-MSCs become immune-suppressive, observe effect intravenous delivery tumor necrosis factor (TNF)-α transcription expression core infarct areas rats after cerebral ischemia. Methods The...
Objective To explore research progress and application prospects of new MRI technologies in diagnosis treatment osteoarthritis. Methods A computer-based online search Medline database was undertaken to identify the articles about cartilage injury/damage quantitative published English from January 2004 July 2014, with key words ofCartilage injury/damage, osteoarthritis, T1ρmapping, Sodium MRI, magnetization transfer Chemical exchange saturation transfer, Ultrashort echo time DWI, DTI,...
Objectives: Human bone marrow mesenchymal stem cells (hBMSCs) have been used for the prevention and treatment of acute graft-versus-host disease (aGVHD) in post-hematopoietic cell transplant patients. In this study, we compared biological characteristics immunosuppressive activity human amniotic (hAMSCs) hBMSCs to provide experimental evidence potential use hAMSCs treating aGVHD, thus solving problem insufficient sources. Methods: HAMSCs were isolated by enzymatic digestion. using...