A5029751926- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Mesenchymal stem cell research
- Facial Nerve Paralysis Treatment and Research
- Ear Surgery and Otitis Media
- Hearing Loss and Rehabilitation
- Neurogenesis and neuroplasticity mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Surgical Oncology
- Distributed Control Multi-Agent Systems
- Neonatal and fetal brain pathology
- Neural Networks Stability and Synchronization
- Ear and Head Tumors
- Anesthesia and Neurotoxicity Research
- Nasal Surgery and Airway Studies
- Tracheal and airway disorders
- Pluripotent Stem Cells Research
- Adrenal and Paraganglionic Tumors
- Nonlinear Dynamics and Pattern Formation
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Vestibular and auditory disorders
- Neonatal Respiratory Health Research
- Hydrology and Sediment Transport Processes
- Hydrology and Watershed Management Studies
Shanghai Ninth People's Hospital
2016-2025
Shanghai Jiao Tong University
2016-2025
Chinese PLA General Hospital
2013-2025
Tsinghua University
2021-2025
Shanghai University
2016-2024
Jining University
2017-2024
China Three Gorges University
2023
Chinese People's Liberation Army
2018-2023
China Institute of Water Resources and Hydropower Research
2015-2023
Korea Advanced Institute of Science and Technology
2023
Abstract The endothelial-to-mesenchymal transition (EndMT) is an important source of fibrotic cells in idiopathic pulmonary fibrosis (IPF). However, how endothelial (ECs) are activated and EndMT impact IPF remain largely elusive. Here, we use unsupervised pseudotemporal analysis to recognize the heterogeneity ECs reconstruct trajectory bleomycin (BLM)-treated Tie2 creER/+ ;Rosa26 tdTomato/+ mice. Genes like C3ar1 Lgals3 (protein name galectin-3) highly correlated with transitional...
Sporadic vestibular schwannoma (acoustic neuroma) is a benign tumor arising from cochleovestibular nerve. Nowadays, various specialties and medical centers are treating this disease, the multidisciplinary collaboration trend. In an effort to promote uniform standard for reporting clinical results, even treatment indications, mainly controversies were posed discussed during 7th International Conference on acoustic neuroma, agreement was summarized by Committee of conference. The main symptoms...
Abstract The triple‐negative breast cancer is the most malignant type of cancer. Its pathogenesis and prognosis remain poor despite significant advances in diagnosis therapy. Meanwhile, long noncoding RNAs (LncRNAs) play a pivotal role progression tumors. In this study, we found that LncRNA‐ZEB2‐AS1 was dramatically up‐regulated our specimens cells (MDA231), especially metastatic tumor highly invasive cells, high lncRNA‐ZEB2‐AS1 expression associated with clinicopathologic features short...
Infants exhibit remarkable language acquisition abilities, supported by highly plastic neural substrates that dynamically interact with early speech experiences. However, the developmental mechanisms of these and their specific role in remain incompletely understood. Here, we present NeoAudi Tract (NAT), a robust automated toolbox for extracting full set auditory tracts infants from birth to 24 months using $3$T diffusion MRI data. By characterizing microstructural changes tracts,...
Infants exhibit remarkable language acquisition abilities, supported by highly plastic neural substrates that dynamically interact with early speech experiences. However, the developmental mechanisms of these and their specific role in remain incompletely understood. Here, we present NeoAudi Tract (NAT), a robust automated toolbox for extracting full set auditory tracts infants from birth to 24 months using 3T diffusion MRI data. By characterizing microstructural changes tracts, demonstrate...
Rheumatoid arthritis (RA) is a chronic autoimmune disease and the integrity of CX3CR1+ synovial macrophage barrier significantly impacts its progression. However, mechanisms driving dynamic changes this remain unclear. Traditional drug therapies for RA have substantial limitations. Mesenchymal stem cells (MSCs)-based cell therapy, especially adipose-derived (ADSCs), hold therapeutic promise. Nevertheless, underlying mechanism ADSCs, their interactions with macrophages, require further...
This study aimed to investigate the impact of human umbilical cord–derived mesenchymal stromal cells (hUC-MSCs) on food allergy (FA) mice induced by ovalbumin. The percentage regulatory T (Tregs) was assessed administering hUC-MSCs intravenously FA mouse models with oral challenges, allergic responses and levels related cytokines. phenotypes were analysed using flow cytometric analysis. Immunohistochemistry used for histology observation. Real-time polymerase chain reaction (PCR) gene...
Abstract Hearing and speech outcomes of pediatric patients with auditory brainstem implants (ABI) are variable, the underlying developmental mechanism remains unexplored. This study aims to evaluate effectiveness ABI in congenital non‐tumor hearing loss elucidate role cortical plasticity development. A prospective cohort is conducted involving 112 consecutive who received at a tertiary university‐based referral center from January 2019 October 2023. The mean age time surgery postoperative...
Epithelial-mesenchymal transition (EMT) is one of important steps that lead to cancer metastasis. ) a T helper 17 (Th17) cells-secreted cytokine, it can promote invasion and metastasis many cancers.MiR-486-5p microRNA known function as tumor suppressor, bioinformatics analysis predicts Dock-1 has binding site miR-486-5p.In current research, we examined the relative expression levels miR-486-5p in 80 pairs breast tissues corresponding adjacent normal tissues, also effects modifying their...
The aim of the present study was to evaluate association between levels lipids and B-type natriuretic peptide (BNP) in systemic lupus erythematosus (SLE) patients with heart failure (HF). A total 46 active SLE 40 healthy, age-matched control subjects were studied. BNP measured by an immunofluorescence assay fresh plasma. Total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL-C), low-density cholesterol, apolipoprotein (Apo) B, ApoA-I lipoprotein(a) assessed. Compared...
The great majority of sporadic vestibular schwannomas (VSs) are due to the inactivation NF2 gene. In this study, we found age-dependent differences in clinical parameters VSs. Young patients were characterized by progressive tumour behaviours, including earlier onset initial symptoms, shorter symptom duration and larger size. An increased rate "two-hits" both alleles, usually mutation allelic loss, was observed young cases compared older, correlated with loss protein mRNA expression....
Management of small vestibular schwannomas (VSs) consists three options: serial observation, radiosurgery, and microsurgery. The authors reported the long-term hearing outcomes after retrosigmoid tumor removal in 110 patients follow-up 160 observation with VSs to explore appropriate management strategy predictive factors preservation for VSs.Retrospective study.Tertiary referral center.In this study, VS (purely intracanalicular/cerebellopontine angle ≤15 mm) during a 15-year period, from...
<b><i>Background/Aims:</i></b> The present study was a retrospective analysis of surgical outcomes large or giant vestibular schwannomas (VSs) via translabyrinthine approach (TLA). <b><i>Methods:</i></b> One hundred and fifteen sporadic VSs (maximal diameter in the cerebellopontine angle ≥31 mm) were operated TLA between January 2001 December 2010. We divided patients into two groups: cystic VS (CVS) solid (SVS) group. recorded compared....
Background Long non‐coding RNAs (lncRNAs) participate in many biological dynamics and play significant roles gene regulation. LncRNA expression is altered cancers; however, the expressions functions of lncRNA genes lung adenocarcinoma (LAD) remain unknown. Methods messenger RNA (mRNA) LAD without lymphatic metastasis versus paired adjacent non‐tumor (ANT) tissues with were analyzed using Human Arraystar V3.0. The levels four downregulated upregulated lncRNAs verified quantitative real‐time...
The mutation spectrum of deafness genes may vary in different ethnical groups. In this study, we investigated the genetic etiology nonsyndromic four consanguineous and two multiplex Uyghur families which mutations common GJB2, SLC26A4 MT-RNR1 were excluded. Targeted next-generation sequencing 97 was performed probands each family. Novel pathogenic identified including p.L416R/p.A438T compound heterozygous TMC1, homozygous p.V1880E MYO7A, c.1238delT frameshifting deletion PCDH15 c.9690+1G>A...
Profound congenital sensorineural hearing loss (SNHL) prevents children from developing spoken language. Cochlear implantation and auditory brainstem can provide partial sensation, but language development outcomes vary, particularly for patients with inner ear malformations and/or cochlear nerve deficiency (IEM&CND). Currently, the peripheral structure is evaluated through visual inspection of clinical imaging, this method insufficient surgical planning prognosis. The central pathway also...
Diabetic retinopathy (DR) is one of the most common and specific complications diabetes. Thus, intervention required to lower incidence prevalence sight-threatening retinopathy. The aim this study was investigate diabetic in elderly patients receiving early diagnosis proper treatment explore risk factors for DR. From May 2005 2011, fundus examination performed during routine medical examinations. presence a microaneurysm or more severe presentations used diagnose DR, which followed by...
Ras homolog gene family member A (RhoA) has been identified as a critical regulator of tumor aggressive behavior. In this study, we assessed the role RhoA in mechanisms underlying growth, migration, and invasion squamous cell carcinoma tongue (TSCC). Stable knockdown TSCC lines SCC-4 CAL27 were achieved using Lentiviral transfection. The effects depletion on invasion, proliferation determined. possible mechanism line was also evaluated by determining expression Galectin-3 (Gal-3), β-catenin,...