A5102702125- Inflammasome and immune disorders
- Epilepsy research and treatment
- Extracellular vesicles in disease
- Immune cells in cancer
- Osteoarthritis Treatment and Mechanisms
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Chemokine receptors and signaling
- Inflammatory mediators and NSAID effects
Tsinghua University
2025
Xinxiang Medical University
2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Rheumatoid arthritis (RA) is a chronic autoimmune disease and the integrity of CX3CR1+ synovial macrophage barrier significantly impacts its progression. However, mechanisms driving dynamic changes this remain unclear. Traditional drug therapies for RA have substantial limitations. Mesenchymal stem cells (MSCs)-based cell therapy, especially adipose-derived (ADSCs), hold therapeutic promise. Nevertheless, underlying mechanism ADSCs, their interactions with macrophages, require further...
To investigate the effects of inhibiting NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome on neuronal damage and chronic pro-inflammatory responses during epileptogenesis in a mouse model pilocarpine-induced status epilepticus (SE).
Osteoarthritis (OA) is the most prevalent cartilage degenerative and low-grade inflammatory disease of whole joint. However, there are currently no FDA-approved drugs or global regulatory agency-approved treatments OA modification. Therefore, it’s essential to explore novel effective therapeutic strategies for OA. In our study, we investigated effects AFK-PD, a pyridone agent, on development induced by destabilization medial meniscus (DMM) in vivo , its impact function chondrocytes treated...