Microbial contamination is the principal factor in deterioration of postharvest storage quality grapes. To mitigate this issue, we explored a synergistic treatment which combines ultrasound (US) and slightly acidic electrolyzed water (SAEW), rigorously compared with conventional cleaning (CW), exclusive US treatment, standalone SAEW treatment. The + proved to be markedly superior reducing total bacterial, mold & yeast counts on Specifically, it achieved reductions 2.23 log CFU/g 2.76 CFU/g,...

Cerebral palsy (CP) is a chronic nervous system disease that severely damages the physical and developmental health of children. Traditional treatment brings about only improvement mild to moderate CP, but severe CP still lacks effective interventions. To explore safety efficacy using neural progenitor cells (NPCs) treat in children, we performed NPC transplantation 45 patients with by injecting NPCs derived from aborted fetal tissue into lateral ventricle. Gross motor function measures...

Getah virus (GETV) is a mosquito-borne that was first determined in Malaysia 1955, and can infect humans multiple other mammals. GETV infection horses has been reported Japan India, causes great economic losses. In China, identified mosquitoes, pigs, foxes, cattle with wide geographical distribution, but not detected horses. August 2018, sudden onset of fever observed racehorse an equestrian training center Guangdong Province southern China. Blood samples were collected from the sick horse,...

ABSTRACT Pertussis, a severe infectious disease in children, has become increasingly prominent recent years. This study aims to investigate the role of MASP1 protein pertussis children through multi-omics analysis, providing theoretical basis for development novel therapeutic strategies. The retrieved macro-genome and 16S rRNA data pediatric from public databases analyze microbial diversity specific flora abundance, conducting pathway functional enrichment analysis. Differential expression...

Newcastle disease virus (NDV) has been classified by the World Organization for Animal Health (OIE) as a notable disease-causing virus, and this ability to infect wide range of birds. V protein is non-structural NDV. reported inhibit cell apoptosis (Park, et al., 2003a) promote viral replication(Huang, 2003), however, mechanisms action have not elucidated. In present study, yeast two-hybrid screen was performed, found interact with CacyBP/SIP protein. The results co-immunoprecipitation...

Many viral proteins are related to suppressing apoptosis in target cells and hence beneficial replication. The V protein of Newcastle disease virus (NDV) is one such that plays an important role inhibiting a species-specific manner. However, date, there have been no reports clarifying the antiapoptotic mechanisms protein. present study was undertaken determine apoptotic potential chicken embryo fibroblast cell line (DF-1 cell) elucidate its molecular action. Here, yeast two-hybrid system...

Dihydromyricetin (DHM) is a plant flavonoid and the primary active ingredient isolated from medicinal herb, Ampelopsis grossedentata. DHM has been shown to possess various pharmacological activities, including anti‑inflammatory effects. However, possible role of in asthma treatment remains be elucidated. The present study aimed investigate its properties mice with symptoms allergic asthma. C57BL/6 were sensitized challenged ovalbumin (OVA) induce or phosphate‑buffered saline was administered...

Abstract Background The incidence of pertussis shows an increasing trend in recent years, but some clinicians often lack sufficient understanding the clinical characteristics and risk factors for severe pertussis, more effective measures should be taken to reduce mortality young infants Methods A retrospective study was conducted, 184 children with who had been hospitalized Department Pediatrics Beijing Ditan Hospital affiliated Capital Medical University from January 2016 December 2017 were...

Several types of C-band broadband multibeam klystrons (MBKs) are under development at the Institute Electronics, Chinese Academy Sciences. These MBKs operate various frequencies and have peak powers 30-200 kW, average 2-10 bandwidths 4%-7%. The design considerations for obtaining high power wide instantaneous test results these presented in this paper. main technical problems, including a sag band, voltage breakdown, non-operating mode oscillation, also discussed. Further research work...

Newcastle disease virus (NDV) can select cells to infect, but the mechanism of its cell selectivity has not been comprehensively investigated. Here, we use HeLa establish that NDV selectively infect at single-cell level. We labeled proliferating with 5'-bromo-2-deoxyuridine (BrdU) and examined colocalization BrdU in clarify relationships between infection proliferation. Receptors plasma membrane mediate entry into host cells. sialic acid receptor isoforms, compared their densities different...

The role of tumor markers in pulmonary alveolar proteinosis (PAP) remains unclear. This study investigated the serum and bronchoalveolar lavage fluid (BALF) PAP patients explored relationship between severity PAP.We retrospectively reviewed 38 with PAP.Mean carcinoembryonic antigen (CEA) CYFRA21-1 levels were higher than cut-off values (12.7 ± 17.5 ng/mL 10 10.66 ng/mL, respectively). Significant correlations found CEA neuron-specific enolase (NSE) lactate dehydrogenase (LDH) (r=0.60,...

Newcastle disease virus (NDV) can infect a wide range of domestic and wild bird species. The non-structural V protein NDV plays an important role in antagonizing innate host defenses to facilitate viral replication. However, there is lack knowledge related the mechanisms through which regulates extracellular signal-regulated kinase (ERK) signaling pathway involved variety functions activated by several stimuli, including In this study, we show that both lentogenic strain, La Sota, velogenic...

Conventional treatment suffers from a dilemma of poor efficacy. The clinical use Janus kinase (JAK) inhibitors in the steroid-induced rosacea has rarely been explored.We present case successfully treated with JAK inhibitor tofacitinib, no adverse effects.This report successful shows good efficacy tofacitinib SIR.JAK may be promising agent for rosacea, especially patients who have failed to conventional therapy.

The Institute of Electronics, Chinese Academy Sciences, started developing X-band multibeam klystrons (MBKs) in 2000. Three types MBKs are currently under research and development; two operate the fundamental mode (TM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">010</sub> ), other type operates a high-order (coaxial TM xmlns:xlink="http://www.w3.org/1999/xlink">310</sub> ). These over frequency range from 8 to 10 GHz have peak powers 50-100...

ABSTRACT Importance Within the coronavirus disease 2019 (COVID‐19) global pandemic, more attention is warranted for whether this new infectious has unique manifestations in children. Objective To retrospectively determine epidemiological and clinical characteristics of 35 children with COVID‐19 Beijing, China. Methods We collected data diagnosed who were admitted to Beijing Ditan Hospital from January 2020 June 2020, analyzed their characteristics, manifestations, laboratory examinations,...

Abstract Secretory IgA is crucial for preventing the invasion of entero‐pathogens via intestinal mucosa. While it well‐established that Transforming growth factor β1 (TGF‐β1) regulates production in human and mouse B cells, our previous investigation revealed different functions TGF‐β1 generation pigs compared with humans mice, underlying mechanism remaining elusive. In this study, IgM + cells from porcine Peyer's patches (PPs) were isolated stimulated recombinant to evaluate effect on pigs....

The design, manufacture, and test of an S-band high power multibeam klystron (MBK) are presented in this paper. results indicate that the performance MBK satisfies design requirement. Several technical problems, such as oscillation high-order modes, a decrease beam current under no-driver (oscillating) conditions, high-voltage breakdown also discussed. Some improvements have been taken to overcome these problems. improved tube has transmission rate over 98%, operates very stably DC RF conditions.

Transforming growth factor β1 (TGF-β1) performs a critical role in maintaining homeostasis of intestinal mucosa regulation and controls the survival, proliferation, differentiation many immune cells. In this study, we discovered that infection porcine epidemic diarrhea virus (PEDV), coronavirus, upregulated TGF-β1 expression via activating Tregs. Besides, recombinant decreased percentage CD21+ B cells within lymphocyte population vitro. We further found reduced IgA-secreting cell numbers...

ABSTRACT Porcine epidemic diarrhea virus (PEDV) is a pig coronavirus that causes severe and high mortality in piglets, threatening the global industry. Clinically effective medicines against this are still not available. To find an optional natural feed compound, viral titers were detected, intestinal contents of specific pathogen-free pigs more effectively blocked PEDV invasion than those other two breeds investigated. Based on proteomic metabolic analyses content, 10 metabolites selected...