A5101553445- Bone Metabolism and Diseases
- Atrial Fibrillation Management and Outcomes
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Autophagy in Disease and Therapy
- RNA and protein synthesis mechanisms
- Blood Pressure and Hypertension Studies
- Mitochondrial Function and Pathology
- Artificial Intelligence in Healthcare and Education
- Bone health and treatments
- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Anesthesia and Neurotoxicity Research
- COVID-19 diagnosis using AI
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Plant Virus Research Studies
- Pharmaceutical Practices and Patient Outcomes
- Transcranial Magnetic Stimulation Studies
- Intramuscular injections and effects
- Medicinal Plants and Neuroprotection
- NF-κB Signaling Pathways
- RNA modifications and cancer
- Cancer Mechanisms and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
Kyungpook National University
2024-2025
Ningxia Medical University
2023-2025
Korea University
2025
Ningxia Medical University General Hospital
2025
Institute of Medical Sciences
2025
Tangshan Gongren Hospital
2022-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Beijing Hospital
2024
Capital Medical University
2023-2024
Jewish General Hospital
2021-2024
In both prokaryotes and eukaryotes nonsense mutations in a gene can enhance the decay rate of mRNA transcribed from gene, phenomenon described as nonsense-mediated decay. yeast, products UPF1 UPF3 genes are required for this pathway, report we focus on identification characterization additional factors rapid nonsense-containing mRNAs. We present evidence that product UPF2 is new factor involved pathway. Mutation or deletion it chromosome resulted stabilization mRNAs, whereas wild-type...
Background and aimsThe effects of direct oral anticoagulants (DOACs) in patients with non-valvular atrial fibrillation (NVAF) liver disease remain poorly understood. Our multinational cohort study assessed the effectiveness safety DOACs this high-risk population.MethodsWe assembled two population-based cohorts United Kingdom Québec NVAF initiating or vitamin K antagonists (VKAs) between 2011 2020. Using an as-treated exposure definition, we compared to VKAs apixaban rivaroxaban. After...
Abstract Background Secondary bacterial infections and pneumonia are major mortality causes of respiratory viruses, the disruption upper tract (URT) microbiota is a crucial component this process. However, whether URT dysbiosis associates with viral species (in other words, type-specific) unclear. Results Here, we recruited 735 outpatients symptoms, identified infectious virus types in 349 participants using multiplex RT-PCR, profiled their microbiome 16S ribosomal RNA gene metagenomic...
An outbreak of fever and meningitis/encephalitis occurred in Xinjiang, China, from August 5 to September 3, 2004. In preliminary diagnostic testing, several cerebrospinal fluid (CSF) serum samples showed positive immunoglobulin M (IgM) antibody Japanese encephalitis virus. Here, the CSF 6 cases collected at that time were tested by immunofluorescence assay (IFA), enzyme-linked immunosorbent (ELISA), plaque reduction neutralization (PRNT) for existence IgM or against West Nile virus (WNV)...
Although clinical and radiological examinations can be used to diagnose oral cancer, surgical pathology remains the gold standard, these conventional methods have limitations. We evaluated feasibility of longitudinal next-generation sequencing-based liquid biopsy for squamous cell carcinoma surveillance.Eleven patients were enrolled, plasma saliva collected before, 1, 3, 6 months after surgery. Tumor-specific mutations selected using paired, whole-exome analyses tumor tissues whole blood....
Phospholipase C β (PLCβ) is involved in diverse biological processes, including inflammatory responses and neurogenesis; however, its role bone cell function largely unknown. Among the PLCβ isoforms (β1-β4), we found that PLCβ4 was most highly upregulated during osteoclastogenesis. Here used global knockout osteoclast lineage-specific conditional (LysM-PLCβ4-/-) mice as subjects demonstrated a crucial regulator of receptor activator nuclear factor κB ligand (RANKL)-induced differentiation....
<title>Abstract</title> Background Chronic inflammatory disease (CID) is associated with accelerated atherosclerosis and increased risk of aortic stenosis. Data regarding sex-specific outcomes after transcatheter valve implantation (TAVI) in CID patients are lacking. We aimed to investigate sex differences among undergoing TAVI using a nationally representative database. Methods Using the National Inpatient Sample database (2016–2021), we identified who underwent TAVI. These conditions were...
Although it is essential for protein synthesis to be highly accurate, a number of cases directed ribosomal frameshifting have been reported in RNA viruses, as well procaryotic and eucaryotic genes. Changes the efficiency can major effects on ability cells propagate viruses which use this mechanism. Furthermore, studies process illuminate mechanisms involved maintenance normal translation reading frame. The yeast Saccharomyces cerevisiae killer virus system uses programmed −1 synthesize its...
Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation gene expression. MiRNA dysregulation has previously been implicated in induction epilepsy. In this study, we examined effect silencing miR-134 against status epilepticus (SE). Our results showed that level was significantly up-regulated rat after Kainic acid (KA)-induced SE. TUNEL staining alleviated...
ABSTRACT Purpose The optimal design for pharmacoepidemiologic drug–drug interactions (DDIs) studies is unclear. Using the association between concomitant use of sulfonylureas and warfarin risk severe hypoglycemia as a case study, DDI with little or no clinical impact, we tested whether prevalent new‐user can be applied in area. Methods Among all patients initiating UK's Clinical Practice Research Datalink (1998–2020), identified those adding‐on while on sulfonylurea. For each co‐exposed...
Programmed −1 ribosomal frameshifting is utilized by a number of RNA viruses as means ensuring the correct ratio viral structural to enzymatic proteins available for particle assembly. Altering efficiencies upsets this ratio, interfering with virus propagation. We have previously demonstrated that compounds alter kinetics peptidyl-transfer reaction affect programmed frameshift and interfere propagation in yeast. Here, use genetic approach lends further support hypothesis alterations...
To search for novel potential protein biomarkers the early detection and better intervention of pancreatic ductal adenocarcinoma (PDAC).Eight pairs matched PDAC non-cancerous pancreas tissues were profiled with two-dimensional electrophoresis; differentially expressed proteins identified by mass spectrometry. Expression patterns TBX4 (T-box transcription factor TBX4) HSP60 (60 KDa heat shock protein) studied immunohistochemistry using tissue microarrays.A total 48 identified; 30 them are...
Prior studies have suggested that the chronic inflammatory response has an important role in pathophysiology of slow coronary flow phenomenon (SCFP). However, data are scarce regarding plasma fibrinogen-to-albumin ratio (PFAR) patients having SCFP without obstructive artery disease (CAD). In this study, we investigated relationship between PFAR and presence CAD.From January 2021 to 2023, consecutively recruited 1085 CAD according diagnostic exclusion criteria. total, was diagnosed 70...
Phenazine-1-carboxamide (PCN) produced by multifarious Pseudomonas strains represents a promising candidate as new metabolite pesticide due to its broad-spectrum antifungal activity and capacity induce systemic resistance in plants. The rice rhizosphere strain PA1201 contains two reiterated gene clusters, phz1 phz2, for phenazine-1-carboxylic acid (PCA) biosynthesis; PCA is further converted into PCN this using functional phzH-encoding glutamine aminotransferase. However, levels constitute...
Hypoxia drives aging and promotes age-related cognition hearing functional decline. Despite the role of erythrocytes in oxygen (O 2 ) transport, their onset cognitive decline loss (HL) remains undetermined. Recent studies revealed that signaling through erythrocyte adenosine A2B receptor (ADORA2B) O release to counteract hypoxia at high altitude. However, nothing is known about a for ADORA2B Here, we report murine erythrocyte–specific (e Adora2b −/− accelerates early impairments spatial...