A5021753308- Oral and Maxillofacial Pathology
- Salivary Gland Tumors Diagnosis and Treatment
- Tumors and Oncological Cases
- Oral and gingival health research
- Bone Tumor Diagnosis and Treatments
- Cancer, Hypoxia, and Metabolism
- Supply Chain Resilience and Risk Management
- Histone Deacetylase Inhibitors Research
- Oral microbiology and periodontitis research
- Epigenetics and DNA Methylation
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Osteomyelitis and Bone Disorders Research
- Dental Implant Techniques and Outcomes
- Hippo pathway signaling and YAP/TAZ
- Manufacturing Process and Optimization
- Vascular Malformations and Hemangiomas
- Antifungal resistance and susceptibility
- Extracellular vesicles in disease
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Soft tissue tumor case studies
- Psoriasis: Treatment and Pathogenesis
- Connexins and lens biology
- Teratomas and Epidermoid Cysts
- Histiocytic Disorders and Treatments
Nankai University
2024-2025
Yonsei University
2019-2024
Yonsei University College of Dentistry
2020-2024
New Generation University College
2022
Seoul National University
2022
Ajou University
2022
Yonsei University Dental Hospital
2020
Histone acetylation involves the transfer of two-carbon units to nucleus that are embedded in low-concentration metabolites. We found lactate, a high-concentration metabolic byproduct, can be major carbon source for histone through oxidation-dependent metabolism. Both cells and purified nuclei, 13C3-lactate carbons incorporated into H4 (maximum incorporation: ~60%). In nucleus, this process depends on nucleus-localized lactate dehydrogenase (LDHA), knockout (KO) which abrogates...
In the context of low-carbon transformation, manufacturing enterprises are facing great pressures, and they need to improve their capability in order successfully respond these changes achieve sustainable development. Based on concept organizational resilience, this paper proposed carbon representing ability an organization keep stable, adapt, evolve transformation tried explore role resilience enterprises’ environment, social, governance performance (ESG performance) conditional roles...
Although clinical and radiological examinations can be used to diagnose oral cancer, surgical pathology remains the gold standard, these conventional methods have limitations. We evaluated feasibility of longitudinal next-generation sequencing-based liquid biopsy for squamous cell carcinoma surveillance.Eleven patients were enrolled, plasma saliva collected before, 1, 3, 6 months after surgery. Tumor-specific mutations selected using paired, whole-exome analyses tumor tissues whole blood....
The Wnt and Hippo pathways are tightly coordinated understanding their reciprocal regulation may provide a novel therapeutic strategy for cancer. Anti-helminthic niclosamide is an effective inhibitor of now in phase II trial advanced colorectal cancer (CRC) patients. We found that Axin2, authentic target gene canonical Wnt, acts as aYAP phosphorylation activator APC-mutated CRC. While effectively suppresses it also inhibits Hippo, limiting its potential To overcome this limitation, we...
Dimorphic Candida exist as commensal yeast carriages or infiltrate hyphae in the oral cavity. Here, we investigated clinical relevance of non-pseudomembranous candidiasis (OC) by smears tongue biofilms. We conducted a retrospective study 2829 patients who had regardless OC suspicion. Clinical characteristics were evaluated using novel method assessing hyphae. factors (moderate/severe stimulated pain, pain aggravated stimulation, dorsum appearance and initial topical antifungal use) highly...
Tubulointerstitial renal fibrosis is a chronic disease process affecting kidney (CKD). While the etiological role of transforming growth factor-beta (TGF-β) well known for epithelial–mesenchymal transition (EMT) in disease, effective therapeutics are largely limited. As member TGF-β superfamily, bone morphogenetic protein-7 (BMP-7) plays an important as endogenous antagonist TGF-β, inhibiting fibrotic progression many organs. However, soluble rhBMP-7 hardly available due to its limited...
Background Approximately 30% of diabetic patients develop nephropathy, a representative microvascular complication. Although the etiological mechanism has not yet been fully elucidated, renal tubular damage by hyperglycemia-induced expression transforming growth factor-β (TGF-β) is known to be involved. Recently, new type cell death iron metabolism called ferroptosis was reported involved in kidney animal models which could induced TGF-β. Bone morphogenetic protein-7 (BMP7) well-known...
The concept of adequate surgical margins remains controversial in oral squamous cell carcinoma (OSCC) surgery. This study aimed to identify margin-related indicators that might impact recurrence and survival OSCC patients.Histopathological examination was performed using hematoxylin-eosin-stained margin tissue sections 235 patients. Axin2 Snail expression at the detected by immunohistochemistry. Axin2-Snail cascade on tumorigenesis immortalized human keratinocyte (IHOK) line investigated...
Cutibacterium acnes is a facultative anaerobic, gram-positive rod, and commensal bacterium of the body surface including oral cavity. A causal relationship between C. chronic granulomatous diseases, such as sarcoidosis orthopedic implant-associated infections, has been previously reported. Typically, observed inside macrophages, allowing evasion host immunity, triggering persistent inflammatory response. However, findings have not reported in peri-implantitis lesions. In this case series, we...
Background: Bone morphogenetic protein-7 (BMP-7) antagonises transforming growth factor-β (TGF-β). This study investigated the ability of a prodrug BMP-7, designed as micelle nanoparticles for nasal inhalation, to ameliorate pulmonary fibrosis in bleomycin (BLM)-induced murine model. Materials and Methods: Fluorescently labelled BMP-7 was delivered lungs via inhalation. Thirty-eight C57BL/6J mice were divided into three groups: control, BLM with BMP-7. We then administered vehicle nasally...
A 6 year-old spayed female Poodle presented with a mandibular mass. Radiographic examination revealed osteolysis from the right canine to fourth premolar, along horizontal bone loss and dorsal displacement of first second premolars. Skull cone beam computed tomography at level premolar. destructive lesion was observed in apical area canine, mass invasion interradicular molar near canal. Consequently, unilateral total mandibulectomy skin flap surgery were performed. Histopathological poorly...
Juvenile xanthogranuloma (JXG) is a benign histiocytosis that occurs in the pediatric population.Cutaneous JXG most common form, while extracutaneous lesions, including oral JXG, extremely rare.Cutaneous can occur as multiple lesions and may have systemic visceral involvement, but this not seen JXG.In case, we report solitary at gingiva 3-year old male.
Schwannomas are benign tumors originating from myelinating cells constituting nerve sheaths but rarely contain cellular elements of the nerve. The authors encountered a 47-year-old female patient with schwannoma on anterior mandibular ramus arising buccal nerve, measuring 3 cm×4 cm. Surgical resection was performed preservation via microsurgical dissection. After one month, sensory function recovered without complications.
Lymphomatoid granulomatosis (LYG) is an uncommon Epstein-Barr virus (EBV)-associated B-cell lymphoproliferative disorder distinct from lymphoma.LYG primarily occurs in the lung with or without accompanied lesions skin, central nervous system, kidney, gastrointestinal tract, nose, eyes, liver and oral cavity.Solitary extrapulmonary LYG extremely rare, whether solitary progress onto pulmonary development dysfunction controversial.Herein, we report a case on maxilla gingiva bone exposure...
Lingual cyst is a clinical term indicating occurring within the tongue.Various disease may clinically present as lingual cyst, such foregut dermoid thyroglossal duct salivary hemangioma and ranula.In general, cysts are asymptomatic but cause airway obstruction, feeding or swallowing problems.Most of these lesions can be simply treated by surgical excision with good postoperative healing low recurrence rate.Apart from that, histopathological diagnosis lesion important because it means origin...