A5044663032- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Renal and related cancers
- Histone Deacetylase Inhibitors Research
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Nanowire Synthesis and Applications
- Advanced Sensor and Energy Harvesting Materials
- Mitochondrial Function and Pathology
- Acute Myeloid Leukemia Research
- Nanomaterials and Printing Technologies
- RNA Research and Splicing
- Cancer-related gene regulation
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Microfluidic and Bio-sensing Technologies
- Botulinum Toxin and Related Neurological Disorders
- Organic Electronics and Photovoltaics
- Cerebral Palsy and Movement Disorders
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Diatoms and Algae Research
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Protist diversity and phylogeny
Seoul National University
2018-2025
New Generation University College
2022
Ajou University
2022
Yonsei University
2022
Yonsei University College of Dentistry
2022
Korea Research Institute of Chemical Technology
2012
Pain and Rehabilitation Medicine
2012
Stanford University
2009-2010
We report a comprehensive study of transparent and conductive silver nanowire (Ag NW) electrodes, including scalable fabrication process, morphologies, optical, mechanical adhesion, flexibility properties, various routes to improve the performance. utilized synthesis specifically designed for long thin wires improved performance in terms sheet resistance optical transmittance. Twenty Ω/sq ∼80% specular transmittance, 8 ohms/sq 80% diffusive transmittance visible range are achieved, which...
The removal of bacteria and other organisms from water is an extremely important process, not only for drinking sanitation but also industrially as biofouling a commonplace serious problem. We here present textile based multiscale device the high speed electrical sterilization using silver nanowires, carbon nanotubes, cotton. This approach, which combines several materials spanning three very different length scales with simple dying fabrication, makes gravity fed operating at 100000 L/(h...
Clear cell renal carcinoma (ccRCC), with its hallmark phenotype of high cytosolic lipid content, is considered a metabolic cancer. Despite the implication this lipid-rich in ccRCC tumorigenesis, roles and regulators de novo synthesis (DNL) remain largely unexplained.Our bioinformatic screening focused on ccRCC-lipid phenotypes identified glutathione peroxidase 8 (GPX8), as clinically relevant upstream regulator DNL. GPX8 genetic silencing was performed CRISPR-Cas9 or shRNA lines to dissect...
Acute myeloid leukemia (AML) generally has an unsatisfactory prognosis despite the recent introduction of new regimens, including targeted agents and antibodies. To find a druggable pathway, we performed integrated bioinformatic pathway screening on large OHSU MILE AML databases, discovered SUMOylation validated it independently with external data set (totaling 2959 642 normal sample data). The clinical relevance in was supported by its core gene expression which is correlated patient...
Histone acetylation involves the transfer of two-carbon units to nucleus that are embedded in low-concentration metabolites. We found lactate, a high-concentration metabolic byproduct, can be major carbon source for histone through oxidation-dependent metabolism. Both cells and purified nuclei, 13C3-lactate carbons incorporated into H4 (maximum incorporation: ~60%). In nucleus, this process depends on nucleus-localized lactate dehydrogenase (LDHA), knockout (KO) which abrogates...
Abstract Acetyl-CoA synthetase 2 (ACSS2)-dependent acetate usage has generally been associated with tumorigenesis and increased malignancy in cancers under nutrient-depleted conditions. However, the nutrient metabolic characteristics of liver differ from those other organs; therefore, mechanism ACSS2-mediated metabolism may also cancer. To elucidate underlying mechanisms ACSS2 cancer metabolism, relationships between patient uptake tumor malignancies were comprehensively studied vitro , vivo...
Significance We introduce an in-organelle live NMR metabolomics approach that allows for real-time metabolic monitoring of human mitochondria. The also features more than order magnitude higher sensitivity and much less overlap conventional methods. capability identified acetyl phosphate in mitochondria showed its biphasic kinetic profile typical a reaction intermediate. method allowed estimation pyruvate dehydrogenase enzyme activity according to p53 status, independent competing cytosolic...
Triple-negative breast cancer (TNBC) is the most intractable in women with a high risk of metastasis. While hyper-methylation histone H3 catalyzed by disruptor telomeric silencing 1-like (DOT1L), specific methyltransferase for at lysine residue 79 (H3K79), reported as potential target TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient effective inhibition growth and metastasis TNBC cells. We found that cells had expression level low E-cadherin compared to normal...
Abstract Background Pancreatic cancer (PC) has a grim prognosis, and an early diagnostic biomarker been highly desired. The molecular link between diabetes PC not well established. Methods Bioinformatics screening was performed for serum marker. Experiments in cell lines (5 1 normal lines), mouse models, human tissue staining (37 10 cases) were to test asprosin production from PC. Asprosin’s performance tested with serums multi-center cohorts (347 PC, 209 normal, 55 additional diabetic...
Gut microbiome can affect drug metabolism considerably, leading to modified response. However, quantitative estimation of host vs. microbial contributions in a living host–gut system has been challenging. Using the interspecies Caenorhabditis elegans and gut bacteria, we developed real-time approach for monitoring their metabolic interaction vivo during anticancer 5-fluorouracil (5-FU) metabolism. The fluorine NMR-based yielded 5-FU made by human gut-microbial species variable genetic...
Early diagnosis of hepatocellular carcinoma (HCC) is difficult; the lack convenient biomarker-based diagnostic modalities renders high-risk HCC patients burdened by life-long periodical examinations. Here, a new chemical biopsy approach was developed for noninvasive using urine samples. Bioinformatic screening tumor suppressors yielded glycine N-methyltransferase (GNMT) as biomarker with clinical relevance to tumorigenesis. A liquid chromatography–mass spectrometry (LC-MS)-based detecting...
Rationale: Despite growing evidence for mitochondria's involvement in cancer, the roles of specific metabolic components outside respiratory complex have been little explored. We conducted metabolomic studies on mitochondrial DNA (mtDNA)-deficient (ρ0) cancer cells with lower proliferation rates to clarify undefined mitochondria growth. Methods and results: extensive downregulation, ρ0 exhibited high glycerol-3-phosphate (G3P) level, due low activity dehydrogenase (GPD2). Knockout (KO) GPD2...
<i>Objectives:</i> Using diffusion tensor imaging (DTI), we investigated the state of medial lemniscus (ML), corticospinal tract (CST), and posterior thalamic radiation (PTR), which were expected as probable reasons for clinical hemiplegia in pediatric patients, especially those who showed impaired fine motor control proprioception, but no definite weakness or spasticity. <i>Methods:</i> We recruited 13 hemiplegic patients 8 age-matched healthy subjects. Fractional...
Abstract Background Early diagnosis of Nonalcoholic steatohepatitis (NASH) is crucial to prevent its progression hepatocellular carcinoma, but gold standard still requires invasive biopsy. Here, a new marker-based noninvasive chemical biopsy approach introduced that uses urine-secreted tyrosine metabolites. Methods We first identified NASH-specific decrease in TAT expression, the enzyme degradation pathway (TDP), by employing exometabolome-transcriptome correlations, single-cell RNA -seq,...
Despite the great promise of human pluripotent stem cell (hPSC)-based therapy, safety concerns arise from genetic aberrations during in vitro culture, due to their uncertain consequences. Notably, these confer a survival trait known as “culture-adaptation,” allowing aberrant hPSCs evade apoptosis and outcompete normal cells. Thus, it is crucial develop strategies for selectively eliminating ensure therapeutic applications. Herein, we discovered that with variations exhibited increased...
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Tandem architectures in which multiple energy gaps are combined a series-connected stack of solar cells seen as promising approach to increasing the power conversion efficiency organic commercially relevant values. Even higher efficiencies can be obtained if photocurrent-matching requirement such tandem is removed by use intermediate electrodes multi-terminal multijunction cells. We demonstrate semi-transparent and photovoltaic using laminated metal nanowire mesh low-cost, high-performance...
Embryonic and epiblast stem cells in pre-and post-implantation embryos are characterized by their naive primed states, respectively, which represent distinct phases of pluripotency. Thus, the cellular transition from to pluripotency recapitulates a drastic metabolic remodeling after implantation adapt changes extracellular conditions. Here, we found that inhibition Ampk occurred during with two conventional inhibitors (2i) Mek1 Gsk3b pathways. The accumulation glycogen due was responsible...
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