A5100600136- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Microbial Natural Products and Biosynthesis
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Education and Learning Interventions
- Chemical Synthesis and Analysis
- Cancer therapeutics and mechanisms
- Heat shock proteins research
- Asymmetric Hydrogenation and Catalysis
- Photoreceptor and optogenetics research
- Luminescence and Fluorescent Materials
- Protein Structure and Dynamics
- Computational Drug Discovery Methods
- Glutathione Transferases and Polymorphisms
- Traditional and Medicinal Uses of Annonaceae
- Synthesis and Reactivity of Heterocycles
- Click Chemistry and Applications
- Photosynthetic Processes and Mechanisms
- Light effects on plants
- Educational Research and Pedagogy
- Advanced biosensing and bioanalysis techniques
- DNA Repair Mechanisms
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
Seoul National University
2015-2024
Northwestern University
2023-2024
Kyungpook National University Hospital
2022-2024
Government of the Republic of Korea
2015-2020
Instytut Farmaceutyczny
2018-2020
Seoul Institute
2018
Sookmyung Women's University
2017
Pennsylvania State University
2009-2011
Purdue University West Lafayette
2009-2011
Chungbuk National University
2010
An Escherichia coli dihydrofolate reductase mutant is catalytically defective, because motions in the active site are impaired.
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are used clinically as target therapies for lung cancer patients, but the occurrence of acquired drug resistance limits their efficacy. Nicotinamide N-methyltransferase (NNMT), a cancer-associated metabolic enzyme, is commonly overexpressed in various human tumors. Emerging evidence also suggests crucial loss function microRNAs (miRNAs) modulating tumor progression response to standard therapies. However, precise roles...
Metastatic triple-negative breast cancer (mTNBC) is a fatal type of (BC), and signal transducer activator transcription 3 (STAT3) has emerged as an effective target for mTNBC. In the present study, compound MC0704 was found to be novel synthetic STAT3 pathway inhibitor, its potential antitumor activity demonstrated using in vitro vivo models docetaxel-resistant TNBC cells. Based on marinacarboline (MC), series β-carboline derivatives were synthesized investigated their activities against...
The logical and effective discovery of macrolactams, structurally unique natural molecules with diverse biological activities, has been limited by a lack targeted search methods. Herein, method for macrolactams was devised coupling genomic signature-based PCR screening bacterial DNA library spectroscopic early identification macrolactams. facilitated the efficient selection 43 potential macrolactam-producing strains (3.6% 1,188 screened). amplicons amine-deprotecting enzyme-coding genes were...
The identification of pork in commercially processed meats is one the most crucial issues food industry because religious ethics, medical purposes, and intentional adulteration to decrease production cost.This study therefore aimed develop a method for detection meat products using primers specific pig mitochondrial DNA.Mitochondrial DNA sequences pig, cattle, chicken, sheep were obtained from GenBank aligned.The 294-bp D-loop region was selected as target sequence appropriate designed...
Iron-catalyzed cross-dehydrogenative coupling between methyl arenes and anthranilamides for the direct synthesis of quinazolinones.
The Hsp90 facilitates proper folding of signaling proteins associated with cancer progression, gaining attention as a target for therapeutic intervention. natural rotenoid deguelin was identified an inhibitor, but concerns about neurotoxicity have limited prospects clinical development. In this study, we report progress on analogues that address limitation, focusing the novel analogue SH-1242 candidate to broadly human lung cells, including those are chemoresistant or harboring KRAS...
Triple-negative breast cancer (TNBC) is the most intractable in women with a high risk of metastasis. While hyper-methylation histone H3 catalyzed by disruptor telomeric silencing 1-like (DOT1L), specific methyltransferase for at lysine residue 79 (H3K79), reported as potential target TNBCs, early developed nucleoside-type DOT1L inhibitors are not sufficient effective inhibition growth and metastasis TNBC cells. We found that cells had expression level low E-cadherin compared to normal...
Self-assembling peptides have become an important subclass of next-generation biomaterials. In particular, materials that mimic the properties collagen received considerable attention due to unique natural collagen. Previous peptide-based designs been successful in generating structures with morphological were primarily determined by type self-assembling mechanism. Herein we demonstrate metal ion-promoted, supramolecular assembly collagen-based peptide triple helices into distinct...
Terrelumamides A (1) and B (2), two new lumazine-containing peptides, were isolated from the culture broth of marine-derived fungus Aspergillus terreus. From results combined spectroscopic chemical analyses, structures these compounds determined to be linear assemblies 1-methyllumazine-6-carboxylic acid, an amino acid residue anthranilic methyl ester connected by peptide bonds. These exhibited pharmacological activity improving insulin sensitivity, which was evaluated in adipogenesis model...
Ocular diseases featuring pathologic neovascularization are the leading cause of blindness, and anti-VEGF agents have been conventionally used to treat these diseases. Recently, regulating factors upstream VEGF, such as HIF-1α, emerged a desirable therapeutic approach because use is currently being reconsidered due VEGF action trophic factor. Here, we report novel scaffold discovered through complete structure-activity relationship ring-truncated deguelin analogs in HIF-1α inhibition....
The cultivation of a Streptomyces sp. SD53 strain isolated from the gut silkworm Bombyx mori produced two macrolactam natural products, piceamycin (1) and bombyxamycin C (2). planar structures 1 2 were identified by combination NMR, MS, UV spectroscopic analyses. absolute configurations assigned based on chemical chromatographic methods as well ECD calculations. A new chromatography-based experimental method for determining stereogenic centers β to nitrogen atoms in macrolactams was...
Sorafenib (BAY 43-9006) was developed as a multi-kinase inhibitor to treat advanced renal cell, hepatocellular, and thyroid cancers. The cytotoxic effect of sorafenib on cancer cells results from not only inhibiting the MEK/ERK signaling pathway (the on-target effect) but also inducing oxidative damage off-target effect). inhibitory system Xc
Peptoids, N-substituted glycine oligomers, are versatile peptidomimetics with diverse biomedical applications. However, strategies to the development of novel fluorescent peptoids as chemical sensors have not been extensively explored, yet. Here, we synthesized a peptoid-based probe in which coumarin moiety was incorporated via copper(I)-catalyzed azide-alkyne cycloaddition reaction. Fluorescence newly generated coumarin-peptoid dramatically quenched upon coordination Cu(2+) ion, and...
Abstract The first total syntheses of the bioactive cyclodepsipeptides ohmyungsamycin A and B are described. Key features our synthesis include concise preparation a linear cyclization precursor that consists N ‐methyl amides non‐proteinogenic amino acids, its macrolactamization from bent conformation. proposed structure was revised based on synthesis. cyclic core ohmyungsamycins shown to be responsible for excellent antituberculosis activity, variants with truncated chains were evaluated...
A regiospecific synthesis of naphtho[2,1-b]benzofurans with a substituent at the C6 position was achieved via intramolecular 6-endo-dig electrophilic cyclization under acidic conditions to construct central aromatic C ring. Screening synthesized compounds using high-content imaging system enabled us discover novel dual state emissive 2{1,6}, 2{1,8}, and 2{4,3}, which are highly blue emission in their solid states as well solution most solvents. In addition, 2{4,12}, 2{5,13} were found be...
The synthesis and NMR structural studies are reported for a modular threading tetraintercalator bound to DNA. design is based on 1,4,5,8-tetracarboxylic naphthalene diimide units connected through flexible peptide linkers. Aided by an overall C2 symmetry, analysis verified polyintercalation mode of binding, with linkers alternating in the order minor groove, major analogous how snake might climb ladder. This study represents first and, as such, structurally characterizes new topology...