A5068124673- Natural product bioactivities and synthesis
- Ginseng Biological Effects and Applications
- Lichen and fungal ecology
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Metabolomics and Mass Spectrometry Studies
- Computational Drug Discovery Methods
- Bioactive natural compounds
- Bryophyte Studies and Records
- Natural Antidiabetic Agents Studies
- Carbohydrate Chemistry and Synthesis
- Natural Compound Pharmacology Studies
- Traditional Chinese Medicine Analysis
- Seaweed-derived Bioactive Compounds
- Phytoestrogen effects and research
- Click Chemistry and Applications
- Botany and Plant Ecology Studies
- Microbial Natural Products and Biosynthesis
- Monoclonal and Polyclonal Antibodies Research
- Mycorrhizal Fungi and Plant Interactions
- Marine Sponges and Natural Products
- Protein Structure and Dynamics
- Wood and Agarwood Research
- Essential Oils and Antimicrobial Activity
- melanin and skin pigmentation
Ton Duc Thang University
2017-2025
Seoul National University
2016-2023
University of Minnesota
2023
Georgetown University
1993
The binding pose and affinity between a ligand enzyme are very important pieces of information for computer-aided drug design. In the initial stage discovery project, this is often obtained by using molecular docking methods. Autodock4 Autodock Vina two commonly used open-source free software tools to perform task, each has been cited more than 6000 times in last ten years. It great interest compare success rate programs large diverse set protein–ligand complexes. study, we selected 800...
Abstract AutoDock Vina (Vina) achieved a very high docking‐success rate, , but give rather low correlation coefficient, for binding affinity with respect to experiments. This can be an obstacle ranking of ligand‐binding affinity, which is the main objective docking simulations. In this context, we evaluated dependence R coefficient upon its empirical parameters. affected more by changing gauss2 and rotation than other terms. The rate sensitive alterations gauss1, gauss2, repulsion, hydrogen...
Traditionally, lichen has been used for many purposes, but there remains a lack of understanding regarding the chemical composition and antimicrobial characteristics Diorygma pruinosum , native to Vietnam.
Amiodarone is an effective therapy for arrhythmias, its prolonged management may lead to significant adverse drug reactions. Amiodarone-induced hepatoxicity described by phospholipidosis, hepatic steatosis, cholestatic hepatitis, and cirrhosis. However, the systemic lipidome disturbances underlying toxicological mechanisms remain comprehensively elucidated. Untargeted lipidomics were utilized analyze serum liver samples from rats orally administered a daily dose of amiodarone either 100 or...
From the leaves of Paramignya trimera, a new C23-noreuphane-type triterpenoid, paramignyene (1), together with four known triterpenoids, kansenone (2), eupha-8,25-diene-3β,24-diol-7-one (3), eupha-7,25-diene-3,24-diol (4), and β-sitosterol (5), were isolated structurally elucidated. Paramignyene (1) represents first triterpenoid in nature. Their chemical structures established using comprehensive spectroscopic data (1D- 2D-NMR HRESIMS). All compounds evaluated for their alpha-glucosidase...
Vitex negundo L. (V. negundo) is one of the important medicinal and anticancer enhancer herbs. This plant commonly used in preparation traditional drugs to treat numerous diseases. Inspired by properties this plant, current study aimed investigate antiproliferative potential primary molecular mechanisms apoptotic induction against human HepG2 MCF-7 cell lines, pure compounds isolated from targeted fractions V. which were characterized NMR, FTIR HRMS analysis identified as artemetin (FLV1),...
Lichen-derived monoaromatic compounds are bioactive compounds, associated with various pharmacological properties: antioxidant, antifungal, antiviral, cytotoxicity, and enzyme inhibition. However, little is known about data regarding alpha-glucosidase inhibition antimicrobial activity. Very few were reported to have these activities. In this paper, a series of from lichen source isolated structurally elucidated. They 3,5-dihydroxybenzoic acid (1), 3,5-dihydroxybenzoate methyl (2),...
Adenosma bracteosum and Vitex negundo are natural sources of methoxylated flavonoids. Little is known about the α-glucosidase inhibition multi-methoxylated flavonoid derivatives. Eighteen flavonoids were isolated from A. V. negundo. Seven halogenated derivatives synthesized. Their chemical structures elucidated by extensive NMR analysis high-resolution mass spectroscopy as well comparisons in literature. All compounds evaluated for their inhibition. Most showed good activity with IC50 values...
Resection of liver metastases from colorectal carcinoma can be curative. Unresectable but liver-confined might ablated by high-dose radiation with a similar curative result.At Georgetown University Hospital, 22 patients unresectable hepatic underwent 24 interstitial irradiation procedures at laparotomy in Phase I-II study. A single dose was administered rate iridium-192 afterloader. Dose to the tumor periphery 20 Gy, 25 and 30 Gy 13, 9, 2 procedures, respectively.No acute or chronic toxicity...
α-Glucosidase plays a role in hydrolyzing complex carbohydrates into glucose, which is easily absorbed, causing postprandial hyperglycemia. Inhibition of α-glucosidase therefore an ideal approach to preventing this condition. A novel polyprenylated benzoylphloroglucinol, we named schomburgkianone I (1), was isolated from the fruit Garcinia schomburgkiana, along with already-reported compound, guttiferone K (2). The structures two compounds were determined using NMR and HRESIMS analysis,...
Tecoma stans (L.) Juss. Ex Kunth is widely used in folk medicine. In ethnomedicine, it applied as a cardioprotective, hepatoprotective, antiarthritic, antinociceptive, anti-inflammatory, and antimicrobial. The aqueous extract considered antidiabetic, traditional remedy Mexico. More than 120 chemical constituents have been identified its leaves, barks, roots. However, less known about the phytochemical properties of T. flower extracts. herbal plant Nervilia concolor (Blume) Schltr. native to...
Garcinia schomburgkiana is an edible tree widely distributed in the southern region of Vietnam.
Colorectal cancer (CRC) is one of the most common and lethal cancers. Although numerous studies have evaluated potential biomarkers for early diagnosis, current failed to reach an acceptable level accuracy distant metastasis. In this paper, we performed a gene set meta-analysis in vitro microarray combined results from study with previously published proteomic data validate suggest prognostic candidates CRC Two sets included found 21 significant genes. Of these genes, ALDOA, IL8 (CXCL8),...
Abstract The ocotillol (OCT)‐type saponins have been known as a tetracyclic triterpenoid, possessing five‐ or six‐membered epoxy ring in the side chain. Interestingly, this type saponin was mostly found Panax vietnamensis Ha et Grushv ., Araliaceae (VG), hence making VG unique from other spp. Five OCT‐type saponins, majonoside R2, vina‐ginsenoside R1, pseudoginsenoside RT4, R11, together with three protopanaxadiol (PPD)‐type and four protopanaxatriol (PPT)‐type were evaluated for their...
Panax vietnamensis (PV), a wild species discovered in Vietnam 1973, has been increasingly overexploited due to its economic value and therapeutic uses. This resulted the development of PV cultivation meet market demand. There is little information on accumulation saponins during cultivation, but this could serve as an indication appropriate harvest time. In study we developed HPLC-UV/ELSD method simultaneously determine content 10 characteristic from 2–7 years old, including G-Rb1, G-Rd,...