A5029215954- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Essential Oils and Antimicrobial Activity
- Marine Sponges and Natural Products
- Phytochemical compounds biological activities
- Phytochemistry and Bioactive Compounds
- Ginger and Zingiberaceae research
- Phytochemical Studies and Bioactivities
- Phytochemicals and Antioxidant Activities
- Chemical synthesis and alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Chromatography in Natural Products
- Biological Activity of Diterpenoids and Biflavonoids
- Medicinal Plants and Neuroprotection
- Bioactive Compounds and Antitumor Agents
- Microbial Natural Products and Biosynthesis
- Ethnobotanical and Medicinal Plants Studies
- Alkaloids: synthesis and pharmacology
- Ionic liquids properties and applications
- Allelopathy and phytotoxic interactions
- Fungal Biology and Applications
- Bioactive natural compounds
- Sesquiterpenes and Asteraceae Studies
- Polysaccharides and Plant Cell Walls
Hue University
2016-2025
Hanoi Medical University
2024
Hanoi Medical University Hospital
2024
National Hospital of Pediatrics
2024
Tay Nguyen University
2024
Da Nang Hospital
2024
Vietnam National University of Agriculture
2022
University of Münster
2022
Hanoi National University of Education
2022
University of Toyama
2015-2016
We report the identification and purification of a new inflammatory monokine synthesized by macrophage tumor cell line RAW 264.7 in response to endotoxin. This monokine, which we term "macrophage protein" (MIP), is doublet with an apparent molecular mass approximately 8,000 daltons on SDS-PAGE but forms aggregates greater than 2 x 10(6) as assessed gel filtration. Partial NH2-terminal amino acid sequence data reveal no significant homology any previously described protein. Although anionic...
A sustainable and comprehensive process for extracting triterpenoids from persimmon leaves was developed the first time. This method utilizes deep eutectic solvents extraction macroporous resins recovery of triterpenoids.
Rutin and flavonoids derived from Sophora japonica hold significant potential for various bioactivities. The objective of this study is to improve the ultrasonic-assisted extraction procedure obtaining rutin total japonica. Moreover, purification these ethanol extract was accomplished using macroporous resins. Under optimal conditions, efficiency were 32.49% 48.40%, respectively. Out 11 resins tested purification, results indicated that DAX-8 ADS-7 two most efficient meticulously optimized...
The present study aimed to determine the bioactivities of essential oils extracted from leaves Paramignya trimera and Limnocitrus littoralis, including cytotoxicity, antiviral, antibacterial, antimycotic, antitrichomonas effects. Herein, it was indicated that P. L. littoralis showed no cytotoxicity on normal cells, namely MT-4, BHK-21, MDBK, Vero-76. oil (i) exhibited strongest inhibition against Staphylococcus aureus with MIC MLC values 2% (v/v); (ii) 8% (v/v) in Candida parapsilosis; (iii)...
The rapid emergence of drug-resistant strains and novel viruses have motivated the search for new anti-infectious agents. In this study, chemical compositions cytotoxicity, as well antibacterial, antifungal, antitrichomonas, antiviral activities essential oils from leaves, rhizomes, whole plant Hornstedtia bella were investigated. GC/MS analysis showed that β-pinene, E-β-caryophyllene, α-humulene found at high concentrations in oils. exhibited (i) inhibition against Staphylococcus aureus,...
An efficient choline chloride-based DES method is used to extract curcumin in turmeric residue for the first time.
The aerial parts of Anthemis tinctoria L. and Angelica sylvestris the roots A. have been used as traditional anticancer remedies in Estonian ethnomedicine. aim this study was to investigate content essential oils (by gas chromatography) polyphenolic compounds (using two different methods high performance liquid chromatography-mass spectrometry (HPLC-MS)) both plant species, well vitro anti-cancer effects their methanolic extracts. average (n = 5 samples) yield 0.15%, 0.13%, 0.17%,...
Bone defects are becoming a true challenge in global health care due to the aging population and higher prevalence of musculoskeletal disorders. The interest using plant‐origin compounds plant‐derived biomaterials bone tissue engineering (BTE) has been increased their availability (abundance), safety, biocompatibility, biodegradability, low cost. Plant‐origin have supportive effects on healing, cell‐laden can be applied formulating bioinks for three‐dimensional (3D) bioprinting facilitate...
A new 14-membered cembrane-type diterpenoid, jatrophainolide D (1), along with six known compounds, (E)-phytol (2), lupeol (3), stigmasterol (4), ergosta-4,6,8 (14),22-tetraen-3-one (5), stigmast-4-ene-3-one (6), and ergosterol peroxide (7) were isolated from the aerial parts of Jatropha integerrima. The structure isolates was elucidated by IR, UV, 1D-/2D-NMR, HRESI-TOFMS data as well comparison reported spectroscopic data. All evaluated antibacterial activity against S. enterica, E. coli,...
Objective This study focuses on evaluating the inhibitory activity of pongaglabrone and pongapin, isolated from Pongamia pinnata in our previous research, inhibit α-glucosidase, an enzyme involved carbohydrate metabolism. Inhibition α-glucosidase is a key target for controlling type 2 diabetes, making these compounds promising candidates further research. Methods In vitro assays were conducted to evaluate effects pongapin α-glucosidase. Computational approaches, including Density Functional...
Building predictive models of the cell requires systematically mapping how perturbations reshape each cell's state, function, and behavior. Here, we present Tahoe-100M, a giga-scale single-cell atlas 100 million transcriptomic profiles measuring 1,100 small-molecule impact cells across 50 cancer lines. Our high-throughput Mosaic platform, composed highly diverse optimally balanced 'cell village', reduces batch effects enables parallel profiling thousands conditions at resolution an...
To screen Vietnamese medicinal plants for xanthine oxidase (XO) inhibitory activity and to isolate XO inhibitor(s) from the most active plant. The materials were extracted by methanol. plant fractionated using different organic solvents, including n-hexane, ethyl acetate, n-butanol. Bioassay-guided fractionation column chromatography used compounds. compounds structures elucidated analysis of spectroscopic data, IR, MS, NMR. Three hundreds eleven methanol extracts (CME) belonging 301 herbs...
The present study aimed to determine the antimicrobial activity and chemical composition of leaves-extracted essential oil Leoheo domatiophorus Chaowasku, D.T. Ngo H.T. Le (L. domatiophorus), including antibacterial, antimycotic, antitrichomonas antiviral effects. was obtained using hydrodistillation, with an average yield 0.34 ± 0.01% (v/w, dry leaves). There were 52 constituents as identified by GC/MS available authentic standards, representing 96.74% entire leaves oil. comprised three...
The present study aimed to determine the chemical compositions and bioactivities of essential oil Atalantia sessiflora Guillaumin (A. sessiflora), including antibacterial, antimycotic, antitrichomonas, anti-inflammatory antiviral effects.The from leaves A. was extracted by hydrodistillation using a Clevenger apparatus. Chemical were identified GC/MS. Antimicrobial antitrichomonas activity determined microdilution method; MTT method.The average yield 0.46 ± 0.01% (v/w, dry leaves). A number...
So far, the anticancer action of pine tree extracts has mainly been shown for species distributed widely around Asian countries.Therefore, this study was performed to examine potential cytotoxicity Scots (Pinus sylvestris L.) native also European region and growing in Estonia.The cytotoxic activity methanol extract essential oil needles determined by sulforhodamine B assay different human cancer cell lines.This needle found suppress viability several lines showing some selectivity estrogen...
Abstract Objectives Prostate cancer features have been linked to mutations in the BRCA1 and BRCA2 genes. Assessing status of gene carriers patients contributes accurate diagnosis, disease prognosis as well appropriate targeted treatment methods. This study evaluated prevalence these Vietnamese prostate assessed their correlation with clinical features. Methods A cross-sectional was performed at Bach Mai Hospital between 2021 2022. We enrolled 60 patients. Next-generation sequencing used...