A5079980105- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Colorectal Cancer Treatments and Studies
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Medical Imaging Techniques and Applications
- Management of metastatic bone disease
- Glioma Diagnosis and Treatment
- BRCA gene mutations in cancer
- Cervical and Thoracic Myelopathy
- Advanced Radiotherapy Techniques
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Medical Imaging and Pathology Studies
- Radiation Therapy and Dosimetry
- Peptidase Inhibition and Analysis
- Trigeminal Neuralgia and Treatments
- Cancer Mechanisms and Therapy
- PARP inhibition in cancer therapy
- Radiopharmaceutical Chemistry and Applications
- HER2/EGFR in Cancer Research
- Radiation Dose and Imaging
- Neurosurgical Procedures and Complications
Bạch Mai Hospital
2014-2025
Hanoi Medical University
2019-2025
Abstract Objectives Prostate cancer features have been linked to mutations in the BRCA1 and BRCA2 genes. Assessing status of gene carriers patients contributes accurate diagnosis, disease prognosis as well appropriate targeted treatment methods. This study evaluated prevalence these Vietnamese prostate assessed their correlation with clinical features. Methods A cross-sectional was performed at Bach Mai Hospital between 2021 2022. We enrolled 60 patients. Next-generation sequencing used...
We developed a scoring system to predict 1-year survival after radiosurgery for 1-3 brain metastases. This study aimed validate this system.Seventy-six new patients were included in validation study. Like the original scoring-system, three factors (age, performance status, extra-cranial metastases) used. For each factor, rates % divided by 10, and scoring-points added patient.Patient's scores 11, 13, 14, 16 or 17 points with ranging between 31% 80%. Two groups, 10-14 16-17 formed. In 14-16...
Abstract Background This study aimed to evaluate the efficacy and side effects of first-line afatinib treatment in a real-world setting Vietnam. Methods retrospective was conducted across nine hospitals Advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients who received as therapy between April 2018 June 2022 were included, patient medical records reviewed. Key outcomes overall response rate (ORR), time-to-treatment failure (TTF), tolerability....
Background: Afatinib is indicated for advanced-stage non-small-cell lung cancer (NSCLC) with Epidermal Growth Factor Receptor (EGFR) and uncommon mutations. However, real-world studies on this topic are limited. This study aimed to evaluate afatinib as first-line therapy locally advanced metastatic NSCLC EGFR Patients methods: A retrospective included 92 patients compound mutations, treated therapy. were followed up evaluated every 3 months or when symptoms of progressive disease arose. The...
Afatinib, a second-generation epidermal growth factor receptor(EGFR) tyrosine kinase, has proven effective for non-small-cell lung cancer (NSCLC) patients with EGFR mutations through randomized controlled trials and real-world studies. Elderly exhibit unique characteristics in terms of physical condition comorbidities, leading to differences clinical practice selecting the initial dosage making dose adjustments compared younger patients. This study aims evaluate effectiveness adverse effects...
Numerous patients with few brain metastases receive radiosurgery, either alone or in combination whole-brain irradiation. The addition of irradiation to radiosurgery reduces the rate intracerebral failures, particularly development new cerebral lesions distant from those treated radiosurgery. Less failures mean less neurocognitive deficits. However, itself may lead a decline functions. Therefore, number physicians have reservations regard adding Prognostic factors that allow an estimation...
ABSTRACT Introduction The role of afatinib in the first‐line treatment EGFR‐mutant advanced non–small cell lung cancer (NSCLC) patients has been proven through clinical trials and real‐world studies. However, additional data on effectiveness with brain metastases are lacking. Methods NSCLC were retrospectively reviewed across nine centers Vietnam from April 1, 2018 to June 2022. primary endpoints included central nervous system progression‐free survival (CNS‐PFS) overall (OS). secondary...
We conducted this study to determine the relationship among standardized uptake value (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) indexes of Flourine-18 fluorodeoxyglucose positron emission tomography/computed tomography18 (FDG-PET/CT) imaging Kirsten rat sarcoma (KRAS) gene mutations in colorectal cancer (CRC).This cross-sectional was Bach Mai Hospital from 2020 2022. It included newly diagnosed CRC patients who underwent PET/CT examination prior primary...
Abstract Background: This study aimed to evaluate the efficacy and side effects of first-line afatinib treatment in a real-world setting Vietnam. Methods: retrospective was conducted across nine hospitals Advanced epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) patients who received as therapy between April 2018 June 2022 were included, patient medical records reviewed. Key outcomes overall response rate (ORR), time-to-treatment failure (TTF), tolerability....
This study evaluated the prognostic ability of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed (CT) in patients with stage IV adenocarcinoma lung cancer to detect protein death-ligand 1 (PD-L1) expression levels.In total, 86 underwent 18F-FDG PET/CT imaging and PD-L1 evaluation before treatment from February 2019 November 2020 at Bach Mai Hospital, Hanoi, Vietnam. The assessed patient characteristics this included sex, age, smoking status, epidermal growth factor...
Abstract: This paper aims to determine the rate of epidermal growth factor receptor (EGFR) gene mutations in advanced and metastatic squamous cell lung cancer Vietnamese patients. EGFR mutation testing was performed on 559 formalin-fixed paraffin-embedded tissue samples from patients by real-time PCR. The results showed that were found 8.4%. Most them exon 19 deletions, approximately 51.1%. Multivariate analysis more prevalent gender (p<0.0001). In conclusion, should be with cancer.
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