A5070176357- Computational Drug Discovery Methods
- Nanoparticles: synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Drug-Induced Hepatotoxicity and Protection
- Synthesis and biological activity
- Medicinal Plant Research
- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
- Traditional and Medicinal Uses of Annonaceae
- Plant-derived Lignans Synthesis and Bioactivity
- Extraction and Separation Processes
- Moringa oleifera research and applications
- Recycling and Waste Management Techniques
- Chromatography in Natural Products
- Sirtuins and Resveratrol in Medicine
- Biochemical effects in animals
- Gold and Silver Nanoparticles Synthesis and Applications
- Photochemistry and Electron Transfer Studies
- Phytochemistry and Bioactive Compounds
- Morinda citrifolia extract uses
- Nonlinear Optical Materials Research
- Biodiesel Production and Applications
- RNA and protein synthesis mechanisms
- Antioxidant Activity and Oxidative Stress
- Tuberculosis Research and Epidemiology
Lac Hong University
2020-2025
Federal Scientific Center for Medical and Preventive Health Risk Management Technologies
2023
Russian Academy of Sciences
2023
HUTECH University
2022
The oil spillage and maritime pollution due to spilled have been affecting human life the environment in long term seriously. methods techniques presently used recover spills must be carefully considered avoid creating unexpected secondary as well time-consuming. Therefore, application for recovery should available, fast responsive, economical, highly absorbing, nontoxic environment. use of absorbents originated from natural organic byproducts is a suitable method treating because their...
The development and modernization of the industry are known to bring many benefits for human life, diversify production process create abundant products originated from different materials. Among above-mentioned products, all kinds plastic-based commodities have a huge increase in both quality quantity due their large range applications as well versatility manufacturing use along with lower cost than other. That is why Municipal Solid Waste (MSW) countries world reported contain around 12%...
Sirtuin 1 (SIRT1) belongs to the histone deacetylase enzyme family and its activity regulates various signaling networks associated with aging. SIRT1 is widely involved in a large number of biological processes, including senescence, autophagy, inflammation, oxidative stress. In addition, activation may improve lifespan health numerous experimental models. Therefore, targeting potential strategy delay or reverse aging age-related diseases. Although activated by wide array small molecules,...
Objective This study focuses on evaluating the inhibitory activity of pongaglabrone and pongapin, isolated from Pongamia pinnata in our previous research, inhibit α-glucosidase, an enzyme involved carbohydrate metabolism. Inhibition α-glucosidase is a key target for controlling type 2 diabetes, making these compounds promising candidates further research. Methods In vitro assays were conducted to evaluate effects pongapin α-glucosidase. Computational approaches, including Density Functional...
Abstract In this paper, a novel approach for green chemistry was employed the synthesis of silver nanoparticles (AgNPs) using aqueous leaf extracts Muntingia calabura ( M . ). Characterization AgNPs such as shape, size, morphology, and stability made Ultraviolet‐Visible (UV‐Vis) spectroscopy, transmission electron microscopy (TEM). The results showed surface plasmon band around 427 nm when analyzed via UV‐Vis indicated particles nano dimensions. TEM study revealed that spherical shapes...
Background/Objectives: This study investigated the potential of green algae-derived carotenoids as natural inhibitors proprotein convertase subtilisin/kexin type 9 (PCSK9), a key regulator cholesterol metabolism. PCSK9 promotes degradation low-density lipoprotein receptors (LDLR), thereby increasing blood levels and elevating risk cardiovascular diseases. Methods/Results: We screened pharmacophore fit score 27 with identified 14 that were analyzed for binding affinity molecular interactions....
Using FeS2 (pyrite) as an active material for cathodes in the thermal battery has received much more attention due to its abundant natural resources, cheapness, and excellent efficiency. Nevertheless, scientists take a large internal resistance issue of into urgent consideration, decreasing electrochemical efficiency typical Li–Si/FeS2 batteries. In this study, we surveyed effect binders, thin-film thicknesses, addition conductive carbonaceous additives such carbon black (CB), super P (SP)...
Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of Goniothalamus elegans .
Background: RNA-dependent RNA polymerase (RdRp) contributes to the transcription cycle of SARS-CoV-2 virus with possible assistance nsp-7-8 cofactors. Objective: To investigate viral protective effects complementary drugs in computational approaches that use proteins. Methods: For silico studies, identified compounds were subjected molecular docking RdRp protein followed by structural and functional analyses, density theory (DFT), dynamics (MD) simulation. The 3D structure (6m71 PDB ID) was...
In this study, the molecular structure, vibrational frequencies, and atom-in-molecule (AIM) analysis of benzoic acid monomer dimer were investigated. Geometry optimization frequency calculations for carried out at density functional theory (DFT) level with 6-311++G(2d,p) basis set. UV-Vis spectroscopy electronic properties (i.e., excitation energies, oscillator strengths) calculated by time-dependent DFT (TD-DFT) in different solvents. The absorption values mainly represented from HOMO-1...
<title>Abstract</title> Kadsuric acid, a major triterpenoid isolated from the leaves of Vietnamese <italic>Kadsura coccinea</italic>, exhibited potent cytotoxic effects in some human cancer cells. In this study, kadsuric acid on pancreatic cells PANC-1 were investigated. The results showed that dose-dependent cytotoxicity against with an IC50 value 14.5 ± 0.8 µM. effectively activated caspase-3 by increasing level enzyme cleavage 1–2 times after 12 and 24 h, more than 3–4 compared to...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has quickly become a global health pandemic. Among the viral proteins, RNA-dependent RNA polymerase (RdRp) is responsible for genome replication and emerged as promising target against SARS-CoV-2 infection. Dietary bioactive compounds represent an important source of evolutionarily optimized molecules with antiviral properties RdRp. We investigated inhibitory potential effects different phytochemicals RdRp, including...
Surface-enhanced Raman scattering (SERS) represents a compelling detection methodology centered on the electromagnetic fields, commonly termed "hot spots", generated around noble nanoparticles. Nonetheless, efficacy of field (EMF) amplification is constrained when utilizing individual There has been notable lack experimental and theoretically simulated studies regarding increase gold nanorods with different aspect ratios undergo self-assembly in either perpendicular or parallel orientations...
The silver nanoparticles (AgNPs) are synthesized by various methods and seem to be very hazardous the ecosystem expensive. Hence, present study aimed synthesize homogeneous using Coccinia grandis (L.) Voigt leaf extract with procedures non-toxic, eco-friendly. formation of biologically AgNPs was characterized UV-Visible spectrophotometer (UV-Vis) transmission electron microscope (TEM) techniques. observed visually color change solution from yellow reddish-brown. UV-Vis spectroscopy showed...
Abstract In this study, the molecular geometry structure of ZINC85862539_679 compound was performed by density functional theory (DFT) calculation at B3LYP level 6‐311++G(d,p) basis set. The energies gap HOMO‐LUMO (highest occupied orbital, HOMO and lowest unoccupied LUMO) ZINC85862539_679, chemical reactivity descriptors were also investigated. electrostatic potential (MEP) has been carried out using DFT method. Additionally, inhibition on main protease (M pro ) SARS‐CoV‐2 investigated...