A5069375827- Phytochemical compounds biological activities
- Traditional and Medicinal Uses of Annonaceae
- Plant-derived Lignans Synthesis and Bioactivity
- Drug-Induced Hepatotoxicity and Protection
- Phytochemistry and Bioactivity Studies
- Fungal Biology and Applications
- Pharmacogenetics and Drug Metabolism
- Bioactive Compounds and Antitumor Agents
- Cell death mechanisms and regulation
- Histone Deacetylase Inhibitors Research
- Phytochemistry and Bioactive Compounds
- Botanical Research and Applications
- Microbial Metabolism and Applications
- Moringa oleifera research and applications
- Medicinal plant effects and applications
- Ubiquitin and proteasome pathways
- Antimicrobial Peptides and Activities
- Autophagy in Disease and Therapy
- Biological Activity of Diterpenoids and Biflavonoids
- Algal biology and biofuel production
- PARP inhibition in cancer therapy
- Natural product bioactivities and synthesis
- Biochemical and Structural Characterization
- Insect Utilization and Effects
- Protein Hydrolysis and Bioactive Peptides
University of Da Nang
2023-2024
Ho Chi Minh City Medicine and Pharmacy University
2024
Dong A University
2022-2024
Da Nang University of Technology
2022-2023
In this study, a series of secondary metabolites from Ganoderma sp. were screened against Staphylococcus aureus protein targets, including as phosphotransacetylase, clumping factor A, and dihydrofolate reductase, using molecular docking simulations. The chemicals that showed the strongest binding energy with targeted proteins ganodermanontriol, lucidumol B, ganoderic acid J, ergosterol, ergosterol peroxide, 7-oxoganoderic Z, AM1, ganosinoside D, 24R-ergosta-7,2E-diene-3β,5α,6β-triol....
Two styryl-lactone derivatives (1 and 2) were isolated from the aerial parts of Goniothalamus elegans .
Xanthine oxidase (XO) is a potential target for gout disease experiments on animals and humans. Using molecular docking technique to search anti-XO compounds from Vietnamese medicinal plants, we discovered that numerous Uvaria cordata (Dunal) Alston (Annonaceae family) showed this activity. Among these, cordauvarin A exhibited the strongest binding affinity (−8.8 kcal/mol) XO through interaction with 5 amino acids (eg Gln-1194, Ala-1079, Ser-1080, Met-1038, Arg-912) of protein. Lipinski's...
Breast cancer is the leading cause of mortality in women. In this study, liriodenine and lysicamine from Goniothalamus elegans Ast. were investigated for their anti-breast activity based on molecular interactions with three proteins related to breast cancer. Liriodenine had predicted binding affinities BRCA1, BRCA2, estrogen receptor alpha −6.2, −7.9, −8.3 kcal/mol, respectively. Lysicamine −5.8, −7.2, 7.6 kcal/mol. To evaluate biological lysicamine, we studied vitro cytotoxic effects MCF-7...
<title>Abstract</title> Kadsuric acid, a major triterpenoid isolated from the leaves of Vietnamese <italic>Kadsura coccinea</italic>, exhibited potent cytotoxic effects in some human cancer cells. In this study, kadsuric acid on pancreatic cells PANC-1 were investigated. The results showed that dose-dependent cytotoxicity against with an IC50 value 14.5 ± 0.8 µM. effectively activated caspase-3 by increasing level enzyme cleavage 1–2 times after 12 and 24 h, more than 3–4 compared to...
Abstract In the investigation of cytotoxic activity against leukemia cells Vietnamese medicinal plants, we identified extract Schima wallichii (DC.) Korth as capable inhibiting several cell lines. this study, isolated a main compound kaempferol-3-O-rhamnoside, marking first report being from stem collected in Vietnam. vitro experiments, kaempferol-3-O-rhamnoside exhibited effects on three lines, HL-60 and KG-1. Regarding its mechanism action, effectively inhibited growth KG-1 lines by...
Background: Staphylococcus aureus is a nosocomial pathogen responsible for many serious infectious diseases in humans. Finding the anti- S. agents time-consuming and costly process. Recently, computational methods have provided better understanding of interactions between herbal medicine drug targets to help clinical practitioners rationally design formulae. Methods: In this study, molecular docking simulation was applied screen list natural secondary metabolites from Ganoderma sp. on...
Goniothalamus elegans Ast is a plant commonly used in traditional medicine for the treatment of heart disease and diarrhea. Although there has been one published study on its chemical composition, limited research conducted bioactivity. In this study, aerial part G. was extracted using soaking method further subjected to column chromatography isolation. The isolated compounds were then evaluated cytotoxicity SRB staining. From elegans, four successfully identified as...
Vi khuẩn Gram dương Staphylococcus aureus (tụ cầu vàng) là một mầm bệnh phổ biến gây ra nhiều truyền nhiễm nghiêm trọng ở người, đặc biệt môi trường viện. Do đó, việc tìm kiếm và phát triển các loại thuốc kháng sinh mới hoặc thế hệ để điều trị trùng do S. đang vấn đề cấp thiết đối với y học Việt Nam nói riêng trên toàn giới chung. Trong nghiên cứu này, chúng tôi đã phân lập vi từ nhân da tiến hành khảo sát khả năng ức chế này bởi cao chiết chè dây thu hái tại khu vực Đà Nẵng. Kết quả cho...