A5035927438- Computational Drug Discovery Methods
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Protein Structure and Dynamics
- Alzheimer's disease research and treatments
- Mosquito-borne diseases and control
- Malaria Research and Control
- Synthesis and biological activity
- SARS-CoV-2 and COVID-19 Research
- Influenza Virus Research Studies
- Viral Infections and Outbreaks Research
- Lipid Membrane Structure and Behavior
- Research on Leishmaniasis Studies
- Morinda citrifolia extract uses
- Viral Infections and Vectors
- Meta-analysis and systematic reviews
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Natural product bioactivities and synthesis
- Glycosylation and Glycoproteins Research
- Diverse Scientific Research Studies
- Orthopedic Surgery and Rehabilitation
- Ethics in Clinical Research
- Neuroendocrine regulation and behavior
- Supramolecular Self-Assembly in Materials
Vietnam National University Ho Chi Minh City
2020-2025
Duy Tan University
2017-2024
The University of Texas Health Science Center at San Antonio
2024
Ho Chi Minh City University of Technology
2020-2023
Sorrento Therapeutics (United States)
2023
Vestre Viken Hospital Trust
2023
American University of Antigua
2022
Nagasaki University
2022
Kyoto University
2022
Dongguk University
2021
A combination of Autodock Vina and FPL calculations suggested that<italic>periandrin V</italic>,<italic>penimocycline</italic>,<italic>cis-p-Coumaroylcorosolic acid</italic>,<italic>glycyrrhizin</italic>, and<italic>uralsaponin B</italic>are able to bind well SARS-CoV-2 Mpro.
Abstract The oligomerization of amyloid beta (Aβ) peptides into soluble non-fibrillar species plays a critical role in the pathogenesis Alzheimer’s disease. However, it has been challenging to characterize tertiary and quaternary structures Aβ due their disordered nature high aggregation propensity. In this work, replica exchange molecular dynamics simulations were used explore conformational space 42 monomer. Among most populated transient states, we identified particular conformation which...
In June 2022, Pakistan witnessed catastrophic floods, affecting millions of people. The ensuing epidemics cholera, cryptosporidiosis, rotavirus infections, generalized diarrhoea, typhoid and paratyphoid fevers, as well the frequency vector-borne diseases including malaria dengue fever, are studied in this investigation. It also explores latest outbreak poliomyelitis respiratory such COVID-19, diphtheria, tuberculosis, how floods have contributed to skin eye problems. report describes...
Abstract A highly sensitive immunosensor using streptavidin-conjugated quantum dots (QDs/SA) was developed to detect dengue biomarker of non-structural protein 1 (NS1) at very low concentration, so that it can probe infection even in the early stage. The QDs/SA were first bound biotinylated NS1 antibody (Ab) and QDs/SA-Ab conjugates then used antigen (Ag) Ag concentration range pM 120 nM. formation QDs/SA-Ab-Ag confirmed by measurements field emission scanning electron microscopy (FF-SEM),...
During the COVID-19 pandemic, Afghanistan’s foreign aid-dependent health sector deteriorated with withdrawal of United States and North Atlantic Treaty Organization (NATO) forces due to sudden fall Afghan government Taliban. Although there have been fewer net war-related casualties recently, many people continue die inaccessibility basic medical […]
The M2 channel protein on the influenza A virus membrane has become main target of anti-flu drugs amantadine and rimantadine. structure proteins H3N2 (PDB code 2RLF) 2009-H1N1 (Genbank accession number GQ385383) viruses may help researchers to solve drug-resistant problem these two adamantane-based develop more powerful new against virus. In present study, we searched for inhibitors through a combination different computational methodologies, including virtual screening with docking...
We recently reported that a glycopeptidomimetic molecule significantly delays the fibrillization process of Aβ42 peptide involved in Alzheimer's disease. However, binding mode this compound, named 3β, was not determined at atomic scale, hindering our understanding its mechanism action and impeding structure-based design new inhibitors. In present study, we performed molecular docking calculations dynamics simulations to investigate most probable structures 3β complexed with Aβ protofibrils....
Endocrine and hemodynamic changes associated with the antagonism of fentanyl by nalbuphine have not been reported. Therefore, authors studied ten patients after anesthetic induction thiopental, fentanyl, trachea] intubation aided sucdnylcholine maintenance diazepam, pancuronium, N2O, further doses fentanyl. Eight underwent cholecystectomy, one had a hysterectomy, another an abdominoplasty. After reversal neuromuscular block at conclusion surgery, normal ventilation was restored 0.22 ± 0.02...
The human islet amyloid polypeptide (hIAPP) is an intrinsically disordered protein that can self-assemble into fibrillar aggregates play a key role in the pathogenesis of type II diabetes mellitus. hIAPP transiently adopt α -helix and β -strand conformations could be important intermediate species on fibrillization pathway. However, experimental studies monomeric peptide are limited due to its high aggregation propensity, early steps association not clearly characterized. In particular,...