A5074528425- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Lichen and fungal ecology
- Natural Compound Pharmacology Studies
- Phytochemical compounds biological activities
- Bryophyte Studies and Records
- Botany and Plant Ecology Studies
- Natural Antidiabetic Agents Studies
- Plant biochemistry and biosynthesis
- Bioactive natural compounds
- Alkaloids: synthesis and pharmacology
- Carbohydrate Chemistry and Synthesis
- Phytochemistry and Bioactive Compounds
- Synthesis of Organic Compounds
- Pharmacological Effects of Natural Compounds
- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Phytochemicals and Antioxidant Activities
- Chemical synthesis and alkaloids
- Insect and Pesticide Research
- Crystallization and Solubility Studies
- Phytochemistry and Bioactivity Studies
- Phytochemistry and biological activity of medicinal plants
Thammasat University
2018-2025
Lampang Rajabhat University
2019-2024
Chulalongkorn University
2010-2018
Traditionally, lichen has been used for many purposes, but there remains a lack of understanding regarding the chemical composition and antimicrobial characteristics Diorygma pruinosum , native to Vietnam.
The chemical investigation of the fruits Garcinia schomburgkiana growing in Vietnam led to isolation a new anofinic acid derivative, 5‐hydroxy‐8‐methoxyanofinic (1), xanthone, xanthoschome C (2), and known synthetic phenolic analogue, 4‐(2‐hydroxybenzyl)‐2‐(4‐hydroxybenzyl) phenol (3), along with seven xanthones (4–10). structures all isolated compounds were determined using spectroscopic techniques (NMR MS), conjunction comparison existing literature data. All assessed for their...
From the leaves of Paramignya trimera, a new C23-noreuphane-type triterpenoid, paramignyene (1), together with four known triterpenoids, kansenone (2), eupha-8,25-diene-3β,24-diol-7-one (3), eupha-7,25-diene-3,24-diol (4), and β-sitosterol (5), were isolated structurally elucidated. Paramignyene (1) represents first triterpenoid in nature. Their chemical structures established using comprehensive spectroscopic data (1D- 2D-NMR HRESIMS). All compounds evaluated for their alpha-glucosidase...
Kurz is widely used in folk medicine Eastern Asia and associated with various ethnopharmacological properties including hepatoprotective, antipyretic, analgesic, antidysenteric, anthelmintic activities. Previous phytochemical investigations reported the presence of numerous triterpenes (mostly cycloartanes, ursanes, lupanes, oleananes) along dozens flavonoids. However, extracts
Lichen-derived monoaromatic compounds are bioactive compounds, associated with various pharmacological properties: antioxidant, antifungal, antiviral, cytotoxicity, and enzyme inhibition. However, little is known about data regarding alpha-glucosidase inhibition antimicrobial activity. Very few were reported to have these activities. In this paper, a series of from lichen source isolated structurally elucidated. They 3,5-dihydroxybenzoic acid (1), 3,5-dihydroxybenzoate methyl (2),...
Chemical investigation of the lichen Parmotrema tsavoense led to isolation 5 new depsidones, parmosidones F - J (1: 5: ). These compounds were structurally elucidated using spectroscopic methods including HRESIMS and 2D NMR data. Compounds 1, 3: , 4: evaluated for their inhibition α-glucosidase. All exhibited potent α-glucosidase inhibitory activity with IC50 values ranging from 10.7 17.6 µM, which was much lower than that positive control acarbose (IC50 449 µM).
Bioactive-guided phytochemical investigation of Euphorbia antiquorum L. growing in Vietnam led to the isolation five ent-atisanes, one seco-ent-atisane, and lathyrane (ingol-type). The structures were elucidated as ent-1α,3α,16β,17-tetrahydroxyatisane (1), ethyl ent-3,4-seco-4,16β,17-trihydroxyatisane-3-carboxylate (2), ent-atisane-3-oxo-16β,17-acetonide (3), ent-3α-acetoxy-16β,17-dihydroxyatisane (4), ent-16β,17-dihydroxyatisane-3-one (5), calliterpenone (6), ingol 12-acetate (7). Their...
α-Glucosidase plays a role in hydrolyzing complex carbohydrates into glucose, which is easily absorbed, causing postprandial hyperglycemia. Inhibition of α-glucosidase therefore an ideal approach to preventing this condition. A novel polyprenylated benzoylphloroglucinol, we named schomburgkianone I (1), was isolated from the fruit Garcinia schomburgkiana, along with already-reported compound, guttiferone K (2). The structures two compounds were determined using NMR and HRESIMS analysis,...
Context: Previous studies have shown that extracts of Zizyphus rugosa Lam. (Rhamnaceae) bark contained phytoconstituents with antidiabetic potential to lower blood glucose levels in diabetic rats. However, there has been no report on the active compounds this plant as inhibitors.Objective: We evaluated α-glucosidase inhibitory and antioxidant activities Z. extract. Moreover, phytochemical constituents were isolated characterized.Materials methods: The inhibition crude ethanol extract...
Garcinia schomburgkiana is an edible tree widely distributed in the southern region of Vietnam.
A new labdane-type diterpenoid, named vitexnegundin (1), along with seven known compounds, including vitexilactone (2), vitetrifolin D (3), 13-hydroxy-5(10),14-halimadien-6-one (4), (rel 3S,5S,8R,9R,10S)-3,9-dihydroxy-13(14)-labden-16,15-olide (5), artemetin (6), vitexcarpin (7) and penduletin (8), were isolated from the leaves of Vitex negundo L. Their structures elucidated by using spectroscopic methods, X-ray crystallographic analysis comparison those reported in literature. Moreover, all...
A novel bixanthone, named schomburgkixanthone (1), was isolated from the twigs of Garcinia schomburgkiana, along with six known compounds, griffipavixanthone (2), 4-hydroxyxanthone (3), 2-hydroxyxanthone (4), 1,6-dihydroxyxanthone (5), 1,7-dihydroxyxanthone (6), and 1,3,5-trihydroxyxanthone (7). The structure 1 identified by application NMR MS data analyses comparison previous reports. Compound showed most powerful inhibition rat intestinal α-glucosidase, IC50 values 0.79 for maltase 1.81 mM...
AbstractA new spiroterpenoid, namely tinctorin (1), along with one known compound, norreticulatin (2), were isolated from the lichen Parmotrema tinctorum (Despr. ex Nyl.) Hale. Their structures elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. The absolute configuration of 2 was established for first time. Compound 1 evaluated its inhibitory activity against α-glucosidase found to be inactive.Keywords: Parmeliaceaeparmotrema...
Nine furoquinoline alkaloids (1–9) were isolated from the leaves of Evodia lepta based on bioassay-guided fractionation and chromatographic techniques. All isolates evaluated for their cholinesterase (ChEs) inhibitory activities, in which kokusaginine (7) melineurine (5) exhibited highest activity toward AChE BChE, respectively. Lineweaver- Burk plots indicated that 5 7 mixed mode inhibitors both ChE enzymes. Molecular docking studies binding sites BChE performed order to afford a molecular...
A series of lupeol derivatives 2, 2a-2f, 2a-2h, 3a-3e, and 4a-4b were designed, synthesised evaluated for their α-glucosidase inhibitory cytotoxic activities. Among synthetic derivatives, analogues 2b 2e containing a benzylidene chain exhibited the best activity against superior to positive agent with IC50 values 29.4 ± 1.33 20.1 0.91 μM, respectively. Lupeol 2d 3a showed weak cytotoxicity K562 cell line 76.6 2.40 94.4 1.51