A5006029344- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Gold and Silver Nanoparticles Synthesis and Applications
- Force Microscopy Techniques and Applications
- Conducting polymers and applications
- Cancer, Hypoxia, and Metabolism
- Asymmetric Synthesis and Catalysis
- RNA Interference and Gene Delivery
- Mechanical and Optical Resonators
- Lanthanide and Transition Metal Complexes
- Chemical Synthesis and Analysis
- Nanocluster Synthesis and Applications
- Electrochemical sensors and biosensors
- Characterization and Applications of Magnetic Nanoparticles
- Advanced Biosensing Techniques and Applications
- Carbohydrate Chemistry and Synthesis
- Monoclonal and Polyclonal Antibodies Research
- Analytical Chemistry and Sensors
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Quantum Dots Synthesis And Properties
- Photoacoustic and Ultrasonic Imaging
- Innovative Microfluidic and Catalytic Techniques Innovation
- Molecular Junctions and Nanostructures
Yonsei University
2016-2025
Severance Hospital
2011-2023
Yonsei University Health System
2011-2020
Korea Research Institute of Bioscience and Biotechnology
2010-2020
Government of the Republic of Korea
2015-2019
Seoul Institute
2017
Convergence
2015
University of California, San Diego
2013
The University of Texas Health Science Center at San Antonio
2013
Icahn School of Medicine at Mount Sinai
2013
Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, main absorption band spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength result formation emeraldine salt (see picture). The doped caused photothermal ablation cells upon NIR laser irradiation vitro vivo. Detailed facts importance specialist readers are published "Supporting Information". Such documents...
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA−Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the NPs biodegraded, DOX was released, heat locally generated upon near-infrared (NIR) irradiation due to NIR resonance of Compared with chemotherapy or treatment alone, demonstrated a synergistic effect, resulting in higher therapeutic efficacy shorter times....
Diagnosis and treatment all in one: Multifunctional magneto-polymeric nanohybrids (MMPNs) have been synthesized using ultrasensitive MnFe2O4 nanocrystals, chemotherapeutic agents, encapsulating amphiphilic block copolymers for targeted detection by MRI of breast cancer. See the TEM image (left) an MMPN T2-weighted MR images (top row) color map (bottom relaxivity R2 NIH3T6.7 MDA-MB-231 cells.
Chiral 1,5-diaza-cis-decalins have been examined as ligands in the enantioselective oxidative biaryl coupling of substituted 2-naphthol derivatives. Under optimal conditions employing 2.5−10 mol % a 1,5-diaza-cis-decalin copper(II) catalyst with oxygen oxidant, couplings (44−96% ee) could be achieved for range 3-substituted 2-naphthols including ester, ketone, phosphonyl, and sulfonyl The relationship between substitution naphthalene starting materials reactivity/selectivity is determined by...
Chiral 1,5-diaza-cis-decalins have been examined as ligands in the enantioselective oxidative biaryl coupling of substituted 2-naphthol derivatives. Under optimal conditions employing a 1,5-diaza-cis-decalin copper(I) iodide complex with oxygen oxidant, rapid and highly selective couplings could be achieved (90−93% ee, 85% yield).
Novel hollow silica nanoparticles (HSNPs) for drug delivery vehicles were synthesized using silica-coated magnetic assemblies, which are composed of a number Fe3O4 nanocrystals, as templates. The core cavity was obtained by removal phase with hydrochloric acid and subsequent calcination at high temperature. HSNPs modified amine in order to introduce positive surface charge further PEGylated increased solubility aqueous medium. Doxorubicin model loaded into the HSNPs, notable sustained...
pH-sensitive drug-delivering magnetic nanoparticles (DMNPs) have been developed as theragnostic nanocarriers that release doxorubicin (DOX) under acidic conditions within cancer cells. The drug kinetics of the DMNPs, combined with nanoparticle accumulation pattern in tumor cells, can be monitored by resonance imaging (MRI) to guide decisions regarding optimization dosing schedules.
DOX–magnetic PLGA nanoparticles conjugated with well-tailored antibodies were synthesized for the detection and therapy of breast cancer. Magnetic nanocrystals embedded in polymeric did not inhibit nanoparticle formulation or drug release kinetics. The multimodal demonstrated remarkable cancer cell affinity ultrasensitivity via magnetic resonance imaging. Furthermore, loaded anticancer drugs released sustained three weeks.
We demonstrated that tumors in freshly excised whole brain tissue could be differentiated clearly from normal using a reflection-type terahertz (THz) imaging system. THz binary images of tissues with indicated the tumor boundaries corresponded well to those visible images. Grey and white-matter regions were distinguishable owing different distribution myelin tissue. closely magnetic resonance (MRI) results. The MRI hematoxylin eosin-stained microscopic investigated account for intensity...
Core–multishell nanoparticles: Near-IR-resonant rhodamine-encapsulated poly(lactic-co-glycolic acid) (PLGA)–Mn/Au half-shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from is about twice as great that without indicating possibilities.
Near-infrared-light-sensitive multifunctional smart drug-loaded polymer gold nanoshells are fabricated as advanced prototypes, composed of chemotherapeutic agents (therapeutic antibody and anticancer polymeric nanoparticles) for systemic chemotherapy human epithelial cancer a polymer-based nanoshell localized photothermal treatment by NIR light.
Localized surface plasmon resonance (LSPR) is induced by incident light when it interacts with noble metal nanoparticles that have smaller sizes than the wavelength of light. Recently, LSPR‐based nanobiosensors were developed as tools for highly sensitive, label‐free, and flexible sensing techniques detection biomolecular interactions. In this paper, we describe basic principles nanobiosensing LSPR sensor system biomolecule sensing. We also discuss challenges using biomolecules a biomarker.
Abstract Novel multifunctional magnetic gold nanocomposites (MGNCs) were synthesized for synchronous cancer therapy and diagnosis via resonance imaging (MRI). The MGNCs consist of kernels (aggregates ultra‐sensitive MnFe 2 O 4 nanocrystals wrapped in polymer) as effective MR contrast agents silica–gold hyperthermal therapeutic agents. A antibody, Erbitux (ERB), was conjugated specific tumor cell targeting both to localize the near‐IR laser beam image their events through MRI. ERB‐conjugated...
Well-designed nanoparticle-mediated, image-guided cancer therapy has attracted interest for increasing the efficacy of treatment. A new class smart theragnostic nanoprobes employing cetuximab (CET)-conjugated polyethylene glycol (PEG)ylated gold nanorods (CET-PGNRs) is presented; these target epithelial cells using near-infrared light. The cetyltrimethylammonium bromide bilayer on GNRs replaced with heterobifunctional PEG (COOH-PEG-SH) to serve as a biocompatible stabilizer and increase...
Polymer micelles with bioabsorbable mineralized calcium phosphate nanoshells have been synthesized and demonstrated to be robust nanocarriers for efficient intracellular drug delivery.
We report smart nanoprobe, hyaluronic acid (HA)-based nanocontainers containing miR-34a beacons (bHNCs), for the intracellular recognition of levels in metastatic breast cancer cells, which is distinct from imaging biomarkers such cell membrane receptors as HER2. In this study, we demonstrate that a nanoscale vesicle couples targeting endocytic route, CD44, and molecular probe enables efficient detection specific miRNAs. Furthermore, bHNCs showed no cytotoxicity high stability due to...
Microfluidics has provided biodegradable microcarriers for sustained release of drugs, while allowing insignificant initial bursting. Here, we further engineer the to have multiple compartments distinct drugs in a more controlled fashion. With capillary microfluidic device, monodisperse emulsion drops containing two immiscible biocompatible polymers, one is and other pH-responsive, are prepared, which undergo phase separation as solvent depleted. The finally form uniform with compartments....
Biodegradable microcapsules with a large aqueous lumen and ultrathin membrane are microfluidically designed for sustained release of hydrophilic bioactives using water‐in‐oil‐in‐water double‐emulsion drops as template. As shell phase, an organic solution poly(lactic‐co‐glycolic acid) is used, which consolidated to form biodegradable membrane. The encapsulants stored in the released over long period time membranes degrade. can be controlled range —three five months at neutral pH condition by...
Mitochondrial quality control (MQC) consists of multiple processes: the prevention mitochondrial oxidative damage, elimination damaged mitochondria via mitophagy and fusion fission. Several studies proved that MQC impairment causes a plethora pathological conditions including cardiovascular diseases. However, precise molecular mechanism by which reverses dysfunction, especially in heart, is unclear. The mitochondria-specific peroxidase Peroxiredoxin 3 (Prdx3) plays protective role against...