A5071449410- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Liver Diseases and Immunity
- Alcohol Consumption and Health Effects
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Nanoplatforms for cancer theranostics
- Pancreatitis Pathology and Treatment
- Nanoparticle-Based Drug Delivery
- Lipid metabolism and disorders
- Nutrition and Health in Aging
- Diet and metabolism studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Nutritional Studies and Diet
- Hepatitis B Virus Studies
- Photoacoustic and Ultrasonic Imaging
- Education, Safety, and Science Studies
- Education and Learning Interventions
- Clinical Nutrition and Gastroenterology
- Systemic Sclerosis and Related Diseases
- Field-Flow Fractionation Techniques
- Cardiovascular Function and Risk Factors
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Luminescence and Fluorescent Materials
Myongji Hospital
2022-2024
Hanyang University
2020-2024
Hanyang University Seoul Hospital
2022
Medical University of Vienna
2022
Krankenhaus Oberndorf
2022
Paracelsus Medical University
2022
Eulji University Hospital
2021
Eulji University
2021
Yonsei University
2008-2011
Infiltrate and destroy: In an environment rich in protonating or oxidative species, such as the intracellular milieu of cancer cells, main absorption band spherical, water-soluble polyaniline nanoparticles was red-shifted to a near-infrared (NIR) wavelength result formation emeraldine salt (see picture). The doped caused photothermal ablation cells upon NIR laser irradiation vitro vivo. Detailed facts importance specialist readers are published "Supporting Information". Such documents...
To facilitate combined doxorubicin and photothermal treatments, we developed doxorubicin-loaded poly(lactic-co-glycolic acid)-gold half-shell nanoparticles (DOX-loaded PLGA−Au H-S NPs) by depositing Au films on DOX-loaded PLGA NPs. As the NPs biodegraded, DOX was released, heat locally generated upon near-infrared (NIR) irradiation due to NIR resonance of Compared with chemotherapy or treatment alone, demonstrated a synergistic effect, resulting in higher therapeutic efficacy shorter times....
Doxorubicin-loaded PEG-PLGA-Au half-shell nanoparticles provide multifunctions, such as photothermal treatment, photothermally controlled drug delilvery, and in vivo optical imaging. In addition, the combined doxorubicin treatments using these multifunctional show synergistic therapeutic effects. Detailed facts of importance to specialist readers are published "Supporting Information". Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by authors....
Core–multishell nanoparticles: Near-IR-resonant rhodamine-encapsulated poly(lactic-co-glycolic acid) (PLGA)–Mn/Au half-shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from is about twice as great that without indicating possibilities.
Drug and heat delivery to tumors by active targeting with Herceptin-conjugated doxorubicin-loaded poly(ethylene glycol)–poly(lactic-co-glycolic acid)–Au half-shell nanoparticles (HER-DOX-PLGA-Au H-S NPs) is more effective than passive their HER-free counterparts (DOX-PLGA-Au NPs). Thus, on NIR irradiation, higher intratumoral temperatures were reached in tumor-bearing mice that treated the HER-conjugated particles (see picture). Detailed facts of importance specialist readers are published...
Abstract Background & Aims There are several reports on the prevalence of metabolic dysfunction‐associated fatty liver disease (MAFLD). However, advanced hepatic fibrosis in MAFLD is largely unknown. We aimed to evaluate MAFLD. Methods A total 6775 subjects from nationwide 13 health check‐up centres were included this cross‐sectional study. Fatty was evaluated using ultrasonography. Significant (≥F2) and (≥F3) defined by MRE thresholds 3.0 kPa (range: 2.99–3.65 kPa) 3.6 3.4–3.9...
In einer Umgebung, die reich an protonierenden oder oxidierenden Spezies ist (z. B. in Krebszellen), wird Hauptabsorptionsbande sphärischer, wasserlöslicher Polyanilin-Nanopartikel den Nah-Infrarot(NIR)-Bereich verschoben. Verursacht dies durch Bildung des Emeraldinsalzes (siehe Bild). Die dotierten Nanopartikel verursachen eine photothermische Ablation von Krebszellen bei NIR-Laserbestrahlung vitro und vivo. Detailed facts of importance to specialist readers are published as "Supporting...
Abstract Background & Aims The cost‐effectiveness to screen hepatic fibrosis in at‐risk population as recommended by several professional societies has been limited. This study aimed investigate the of this screening strategy expanded recently proposed societies. Methods A combined model decision tree and Markov models was developed compare expected costs, quality‐adjusted life‐years (QALYs) incremental ratio (ICER) between no groups. included liver disease‐related health states...
The diagnostic performance of the fibrosis-4 index (FIB-4) and nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) for advanced in lean patients with NAFLD is limited.To evaluate FIB-4 NFS individuals NAFLD.This study included adults biopsy-proven from 6 referral centers Asia 1995 to 2019. Cohorts were matched by age sex between nonlean groups. All statistical analyses executed October 2022 March 2023.The at current cutoff hepatic (body mass [BMI] below 23 [calculated as weight...
Fibrosis-4 index (FIB-4) and non-alcoholic fatty liver disease (NAFLD) fibrosis score (NFS) are the two most widely used non-invasive tools for screening of advanced in subjects with NAFLD. Since metabolic dysfunction-associated (MAFLD) has been proposed as a new category disease, we aimed to compare diagnostic performance FIB-4 NFS MAFLD various subgroups.This study was designed cross-sectional study. Data from 6775 who underwent magnetic resonance elastography (MRE) abdominal...
Our study aimed to conduct a comparative evaluation of various noninvasive tests (NITs) for risk stratification in at-risk population non-alcoholic fatty liver disease (NAFLD), focusing on cardiovascular and liver-related mortality. A total 21,715 adults aged 40 years older were enrolled at baseline. The mean follow-up period was 12.39 years. Three types NITs (fibrosis-4 index [FIB-4], NAFLD fibrosis score [NFS], steatosis-associated estimator [SAFE] score) used. When using the low cut-off...
Non-alcoholic fatty liver disease (NAFLD) is often diagnosed incidentally during medical evaluation for diseases other than or health checkups. This study aimed to investigate the awareness, current status, and barriers management of NAFLD in general population. cross-sectional used an online survey, which consisted 3-domain 18-item questionnaires. The content validity index each item questionnaire was rated above 0.80. Most respondents (72.8%) reported having heard term 'NAFLD', a large...
The fibrosis-4 (FIB-4) index is the most widely used estimated formula to screen for advanced hepatic fibrosis; however, it has a considerable intermediate zone. Here, we propose an algorithm reduce zone and improve diagnostic performance of screening liver fibrosis by incorporating Mac-2-binding protein glycan isomer (M2BPGi) into FIB-4 based strategy in average risk group. Four-hundred eighty-eight healthy chronic disease subjects were analyzed using 1:1 propensity score matched age sex....
The current cut-offs for fibrosis-4 (FIB-4) and non-alcoholic fatty liver disease fibrosis score (NFS) are suboptimal screening because of low accuracy high false-negative rates in average-risk populations. This study aimed to reappraisal the performance FIB-4 NFS such populations.This is a cross-sectional study, which retrospectively reviewed magnetic resonance elastography (MRE) data 8,522 subjects. Individuals with history significant alcohol consumption those positive viral serologic...
We aimed to explore the extent which individuals previously diagnosed with nonalcoholic fatty liver disease (NAFLD) meet criteria fulfilled new nomenclature, metabolic dysfunction-associated steatotic (MASLD), within an Asian primary clinic cohort. Additionally, we assessed reliability of diagnostic performance FIB-4 and NAFLD fibrosis score (NFS) for MASLD
Aktive Teilnahme: Der Wirkstofftransport zu Tumoren durch aktives Targeting mit Herceptin-konjugierten Doxorubicin-beladenen Poly(ethylenglycol)-Poly(lactid-co-glycolid)-Au-Halbschalennanopartikeln (HER-DOX-PLGA-Au H-S NPs) ist effektiver als passives den HER-freien Partikeln (DOX-PLGA-Au NPs). Demzufolge wurden dem hypothermischen HER-System bei NIR-Bestrahlung von Tumormäusen höhere intratumorale Temperaturen erreicht (siehe Bild).
Background: The fibrosis-4 index (FIB-4) and the NAFLD fibrosis score (NFS) have been used as noninvasive screening methods for advanced in patients with NAFLD. However, their diagnostic performance has not evaluated at-risk individuals regardless of hepatic steatosis. This study FIB-4 NFS groups health check-up examinees at mass centers. Methods: retrospective, cross-sectional included 8545 participants who underwent voluntary magnetic resonance elastography a discounted fee during regular...
Traditionally, sarcopenia has defined as amount of absolute muscle mass adjusted by height in the elderly people. However, relative weight been used extensively most non-alcoholic fatty liver disease (NAFLD) studies. Here, we attempted to investigate pitfall evaluate association between and NAFLD. Adult subjects (n = 1343) who underwent a health check-up were finally included for analysis. The weight-adjusted skeletal index (wSMI) height-adjusted SMI (hSMI) calculated dividing total...
Screening strategies for hepatic fibrosis are heavily focused on patients with fatty liver sonography in primary care centers. This study aimed to investigate the target population screening significant retrospective cross-sectional cohort used data from 13 nationwide A total of 5111 subjects who underwent both abdominal and magnetic resonance elastography as part their health check-up were included. Subjects viral hepatitis and/or a history alcohol consumption excluded. Significant advanced...
Recently, the classification of fatty liver and definition for non-alcoholic disease (NAFLD) have been challenged. Herein, we aim to evaluate burden hepatic fibrosis in missed added populations following proposal new metabolic dysfunction-associated (MAFLD) a health check-up cohort. A total 6775 subjects underwent both magnetic resonance elastography (MRE) an abdominal ultrasound at 13 nationwide centers Korea. Significant advanced was defined as ≥3.0 kPa ≥3.6 MRE test, respectively. The...