Abstract Objective The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has caused more than 26 million cases Corona virus disease (COVID-19) in the world so far. To control spread disease, screening large numbers suspected for appropriate quarantine and treatment are a priority. Pathogenic laboratory testing is typically gold standard, but it bears burden significant false negativity, adding to urgent need alternative diagnostic methods combat disease. Based on...

Abstract Background The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) has caused more than 2.5 million cases Corona Virus Disease (COVID-19) in the world so far, with that number continuing to grow. To control spread disease, screening large numbers suspected for appropriate quarantine and treatment is a priority. Pathogenic laboratory testing gold standard but time-consuming significant false negative results. Therefore, alternative diagnostic methods are urgently...

Purpose To develop and validate a deep learning system (DLS) for staging liver fibrosis by using CT images in the liver. Materials Methods DLS CT-based of was created development data set that included portal venous phase 7461 patients with pathologically confirmed fibrosis. The diagnostic performance evaluated separate test sets 891 patients. influence patient characteristics techniques on accuracy logistic regression analysis. In subset 421 patients, compared radiologist's assessment,...

Abstract The intestinal microbiota is closely associated with the development of obesity and nonalcoholic fatty liver disease (NAFLD). This study investigated effects probiotic treatment on visceral fat area (VFA) intrahepatic (IHF) fraction in NAFLD. Sixty-eight obese NAFLD patients (>5% proton density [PDFF] magnetic resonance imaging [MRI]) were randomized to placebo groups for 12 weeks. mixture included 6 bacterial species. VFA IHF measured using MRI-PDFF technique. Body weight total...

To determine whether magnetic resonance (MR) enterography performed with diffusion-weighted imaging (DWI) without intravenous contrast material is noninferior to material-enhanced (CE) MR for the evaluation of small-bowel inflammation in Crohn disease.Institutional review board approval and informed consent were obtained this prospective noninferiority study. Fifty consecutive adults suspected having disease underwent clinical assessment, enterography, ileocolonoscopy within 1 week. included...

In relation to the new umbrella terminology for steatotic liver disease (SLD), we aimed elucidate prevalence, distribution, and clinical characteristics of SLD subgroups in primary care setting.

Objective The aims of this study were to assess the confounding effects hepatic iron deposition, inflammation, and fibrosis on steatosis (HS) evaluation by magnetic resonance imaging (MRI) spectroscopy (MRS) accuracies MRI MRS for HS evaluation, using histology as reference standard. Materials Methods In institutional review board–approved prospective study, 56 patients gave informed consents underwent chemical-shift liver a 1.5-T scanner. To estimate fat fraction (FF), 4 analysis methods...

Diffusion-weighted imaging (DWI) is a novel technique to evaluate bowel inflammation in Crohn's disease (CD). It unknown whether and how DWI adds the accuracy of conventional magnetic resonance enterography (MRE).Fifty consecutive adults suspected CD prospectively underwent clinical assessment, MRE at b = 900 sec/mm without water enema, ileocolonoscopy within 1 week. images were interpreted with proper blinding. Forty-four patients finally diagnosed (male:female, 34:10; 26.9 ± 6.1 yr)...

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies to components cell nucleus. These are predominantly produced with help follicular/helper T (Tfh) cells and form immune complexes that trigger widespread inflammatory damage, including nephritis. In recent studies, mesenchymal stem (MSCs) elicited diverse, even opposing, effects in experimental clinical SLE. Here we investigated effect human bone marrow-derived MSCs (hBM-MSCs) a...

Measurement of the liver and spleen volumes has clinical implications. Although computed tomography (CT) volumetry is considered to be most reliable noninvasive method for volume measurement, it limited application in practice due its time-consuming segmentation process. We aimed develop validate a deep learning algorithm (DLA) fully automated using portal venous phase CT images various conditions.A DLA was trained development dataset from 813 patients. Performance evaluated two separate...

This study investigated whether combining niraparib and trabectedin in BRCA-proficient epithelial ovarian cancer induces deficiencies ssDNA break repair dsDNA homologous recombination, leading to synthetic lethality. A2780 SKOV3 cell lines were treated with trabectedin. Cell viability was assessed using CCK-8 assays, while RT-qPCR Western blot analyzed the expression of DNA apoptosis-related genes. Apoptosis evaluated via Annexin V/PI assays. The combination therapy exhibited a synergistic...

INTRODUCTION: Previous studies have shown that ultrasonography has high specificity (80%–100%) but low sensitivity (50%–70%) in diagnosing fatty liver; is especially for mild steatosis. In this study, we aimed to reappraise the diagnostic performance of B-mode (B-USG) liver disease. METHODS: We performed a retrospective, multinational, multicenter, cross-sectional, observational study (6 referral centers from 3 nations). included 5,056 participants who underwent both B-USG and magnetic...

Image findings of intrapancreatic accessory spleen (IPAS) can closely resemble those neuroendocrine tumor (NET) the pancreas.To investigate usefulness diffusion-weighted imaging (DWI) for differentiating IPAS from small (≤3 cm) hypervascular NET pancreas.The visually assessed signal intensity pancreatic lesions compared with on DWI (b value 1000 s/mm(2)) and apparent diffusion coefficient (ADC) values were in 25 patients 31 NET. Two blinded radiologists independently rated their confidence...

To assess the feasibility of proton density fat fraction (PDFF) MRI for estimating hepatic with magnetic resonance spectroscopy (MRS) and histology as references to investigate intrahepatic distribution variability.Between November 2014 September 2015, 85 adults (48 males, 47 females) who underwent MRI-PDFF (n = 139), MRS-PDFF 49) liver biopsy 29) were enrolled in this study. Data compared using linear regression. standard deviations (variability) differences between maximum minimum PDFF...

Abstract Low cut-off of FIB-4 is a widely used formula to exclude advanced liver fibrosis in primary care centers. However, the range reported threshold rule too broad across etiologies, and no consensus has been reached. In present study, we investigated role for reassessment hepatic burden referral center. We compared diagnostic performance among patients with disease various causes tried find an optimal value predicting fibrosis. Among 1068 patients, AUROC diagnose showed significant...

Abstract We aimed to examine the relationship between abdominal computed tomography (CT)-based body composition data and both renal function decline all-cause mortality in patients with non-dialysis chronic kidney disease (CKD). This retrospective study comprised CKD who underwent consecutive unenhanced CT January 2010 December 2011. CT-based was measured using semiautomated method that included visceral fat, subcutaneous skeletal muscle area density, aortic calcium score (AAS). Sarcopenia...

Hepatic sinusoid, the smallest vessel in liver, plays important roles hepatic microcirculation. Although structure of sinusoids affects diverse functions little is known about morphological alterations under pathological conditions. In this study, we show that can be identified three-dimensionally normal and carbon tetrachloride-injured mouse using absorption mode synchrotron radiation micro-computed tomography. We observed sinusoidal on tomographic slice images was similar to histological...