Abstract The intestinal microbiota is closely associated with the development of obesity and nonalcoholic fatty liver disease (NAFLD). This study investigated effects probiotic treatment on visceral fat area (VFA) intrahepatic (IHF) fraction in NAFLD. Sixty-eight obese NAFLD patients (>5% proton density [PDFF] magnetic resonance imaging [MRI]) were randomized to placebo groups for 12 weeks. mixture included 6 bacterial species. VFA IHF measured using MRI-PDFF technique. Body weight total...

Vaginal dysbiosis can lead to serious infections in asymptomatic women. Lactobacillus probiotics (LBPs) are being investigated as a promising therapy for reversing vaginal microbiota dysbiosis. This study aimed investigate whether administering LBPs could improve and facilitate the colonization of species 36 women were classified based on Nugent score Low-NS (n = 26) High-NS 10) groups. A combination acidophilus CBT LA1, rhamnosus LR5, reuteri LU4 was administered orally 6 weeks. The found...

Probiotics have been shown to enhance cognitive function in individuals with mild impairment (MCI), but their efficacy varies, depending on the strain and dosage. Clinical investigations are crucial confirm safety, efficacy, mechanism of action. This study was designed assess effective dosage, MH-Pro, a test product containing Lacticaseibacillus rhamnosus CBT-LR5 (LR5) skim milk (non-fat dry milk), improving related physiological changes older adults suspected MCI over 12 weeks. In total, 20...

Excessive alcohol consumption is one of the most significant causes morbidity and mortality worldwide. Alcohol oxidized to toxic carcinogenic acetaldehyde by dehydrogenase (ADH) further a non-toxic acetate aldehyde (ALDH). There are two major ALDH isoforms, cytosolic mitochondrial, encoded ALDH1 ALDH2 genes, respectively. The polymorphism associated with flushing response use. Emerging evidence shows that Lactobacillus Bifidobacterium species encode (ALDH) mediate metabolism, A randomized,...

Abstract Lactiplantibacillus plantarum , previously named “ Lactobacillus ,” is found in a wide variety of environments exhibiting high level intraspecies genetic diversity. To investigate the strain diversity, we performed comparative genomic analyses 54 complete genome sequences. The results revealed that L. subsp. was split into three lineages, A, B and C. Of genes beneficial for probiotic activity, only those associated with biosynthesis plantaricin (Pln), an -specific bacteriocin, were...

Background/Aims Recently, a number of studies have reported that the gut microbiota could contribute to human conditions, including obesity, inflammation, cancer development, and behavior. We hypothesized composition distribution are different according stool frequency, attempted identify association between frequency. Methods collected fecal samples from healthy individuals divided into 3 groups frequency: group 1, small defecation (≤2 times/wk); 2, normal (1 time/day or 1 time/2 day); 3,...

DATA REPORT article Front. Immunol., 07 April 2017Sec. Microbial Immunology Volume 8 - 2017 | https://doi.org/10.3389/fimmu.2017.00413

Background: The aim of this study was to investigate the efficacy and safety profile switching ezetimibe/simvastatin (Eze/Simva) 10/40 mg compared with doubling statin dose upon discharge in patients taking a admitted hospital for investigation coronary event. Design: This phase IV, multi-centre, randomised, open-label, active-controlled, parallel group enrolled 424 (aged ≥ 18 years) hospitalised an acute event stable (≥ 6 weeks) that could be doubled per product label. Upon from hospital,...

Current evidence support that the gut microbiota plays a potential role in obesity. Bariatric surgery can reduce excess weight and decrease risk of life-threatening weight-related health problems may also influence microbiota. In this study, we aimed to investigate changes before after bariatric evaluate association microbial shift altered body mass index (BMI) surgery.Between January 2019 July 2020, stools from 58 patients scheduled for were collected. Six months surgery, 22 these...

DATA REPORT article Front. Pharmacol., 08 February 2018Sec. Gastrointestinal and Hepatic Pharmacology Volume 9 - 2018 | https://doi.org/10.3389/fphar.2018.00083

The prevalence of obesity in dogs is increasing worldwide. This study evaluated the effects a mixed probiotic formula on weight, body condition score (BCS), blood metabolite profiles, and gut microbiota overweight obese over 12-week supplementation period to determine anti-obesity Lactiplantibacillus plantarum CBT LP3 Bifidobacterium breve BR3. was community-based, randomized that sampled 41 with veterinarian-determined BCS 6 or more. physical activity all subjects measured using pedometer...

Excessive alcohol consumption is one of the significant causes morbidity and mortality worldwide. Alcohol oxidized to toxic carcinogenic acetaldehyde by dehydrogenase (ADH) further a non-toxic acetate aldehyde (ALDH). Emerging evidence shows that Lactobacillus Bifidobacterium species encode (ALDH) mediate metabolism, respectively. This study involves supplementation probiotic mixture in humans assessed their effects on metabolism. Here, twenty-seven wild types (ALDH2*1/*1) same number...

The aim of this study was to evaluate the effects probiotic pretreatment on alteration and recovery gut microbiota after bowel preparation its correlation with minor complications. This a randomized, double-blind, placebo-controlled pilot trial that included participants 40–65 years age. Participants were randomly provided probiotics (active group) or placebo (placebo for 1 month before colonoscopy their feces collected. A total 51 in present (26 active group 25 group). In group, microbial...

We report the genome sequence of Bifidobacterium animalis subspecies lactis BL3, which has preventive properties on acute colitis and colon cancer. The was isolated from Korean faeces, consisted a 1 944 323 bp size single chromosome, its G+C content 60.5%. Genome comparison against closest strain revealed that BL3 had particularly different regions four areas encoding flavin-nucleotide-binding protein, transposase, multidrug ABC transporter ATP binding protein.

The human microbiome exhibits intricate populations across the body, with vaginal tract serving as an ecosystem characterized by prevalence of genus Lactobacillus . Disruptions in microbiota, which are frequently linked to variables such sexual activity, hormonal fluctuations, and excessive use antibiotics, can result dysbiosis development diseases bacterial vaginosis (BV) candidiasis. species, owing their capacity create acidic environment through production lactic acid, have a key function...

Menopause is a significant phase in woman's life. Menopausal symptoms can affect overall well-being and quality of Conventionally, hormone replacement therapy (HRT) used to alleviate menopausal symptoms; however, depending on the conditions, HRT may lead side effects, necessitating exploration alternative therapies with fewer effects. In this study, we investigated effects combination soybean germ extract (S30) containing 30% (w/w) isoflavone probiotic, Lactobacillus gasseri (LGA1),...

The aim of the study was to compare efficacy/safety doubling dose low-, medium- and high-potency statins on lipids/lipoproteins versus ezetimibe/simvastatin (EZE/SIMVA) 10/40 mg in patients with a recent coronary event.In this open-label study, were stratified by baseline statin therapy (low, medium high potency) randomized equally or EZE/SIMVA for 12 weeks. Primary analysis concerned change low-density lipoprotein cholesterol whole population. Treatment-by-stratum interaction evaluated...