Fucoxanthin (FX), a marine carotenoid found in macroalgae and microalgae, exhibits several beneficial effects to health. The anti-obesity activity of FX is well documented, but has not been mass-produced or applied extensively commercially because limited availability raw materials complex extraction techniques. In this study, we investigated the effect standardized powder (Phaeodactylum extract (PE)) developed from microalga Phaeodactylum tricornutum as commercial functional food. PE on...

Background: Alzheimer's disease (AD) is the most common neurodegenerative in older adult population and often associated with reduced physical activity. Reduced activity mechanical loading subsequently reduce bone mineral density increase risk of osteoporosis. Bisphosphonates (BPs) offer preventative effects on osteoporotic fractures general population, but their patients AD are less known. This study aimed to assess impact BPs survival AD. Methods: In this nationwide retrospective cohort...

Background: The operative indication for posterior malleolar fracture (PMF) remains controversial. This study aimed to assess the midterm outcomes of PMF treatment developing a strategy each morphological type. Methods: In this retrospective analysis, patients undergoing an unstable ankle involving were included after at least 3 years follow-up. PMFs classified by morphology according Haraguchi classification. divided entire cohort into three independent populations based on types PMF. For...

Tendon injuries account for 45% of musculoskeletal injuries. However, research on the occurrence and pathogenesis tendinopathy is insufficient, there still much debate regarding treatment methods. It important to understand molecular mechanisms oxidative stress inflammatory responses because in tendon tissue induced by various factors, including cytokines, drug exposure, metabolic abnormalities. In this study, 28 rats were divided into four groups (7 assigned each group): control group...

Background/Objective: The rise in sports participation among children and adolescents has led to an increase ACL injuries skeletally immature individuals. This study analyzed nationwide trends the anterior cruciate ligament (ACL) reconstruction surgeries pediatric adolescent populations, addressing concerns about growth plate disturbances with surgery risks of secondary nonoperative treatment. Methods: We conducted a retrospective population-based cohort using National Health Insurance...

Excessive alcohol consumption is one of the most significant causes morbidity and mortality worldwide. Alcohol oxidized to toxic carcinogenic acetaldehyde by dehydrogenase (ADH) further a non-toxic acetate aldehyde (ALDH). There are two major ALDH isoforms, cytosolic mitochondrial, encoded ALDH1 ALDH2 genes, respectively. The polymorphism associated with flushing response use. Emerging evidence shows that Lactobacillus Bifidobacterium species encode (ALDH) mediate metabolism, A randomized,...

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by the formation of toxic amyloid-β (Aβ) oligomers and plaques. Considering that Aβ misfolding aggregation precedes development cognitive impairment in AD, investigating therapeutic means clearance pre-existing aggregates shows promise as viable disease-modifying treatment. Here, we report small molecule, necrostatin-1 (Nec-1), reduces back to non-toxic monomers vitro vivo . Intravenous administration...

Halitosis, the unpleasant odor in oral cavity, has garnered increased attention and concern due to growing significance of social interaction. SGE-107, a blend 3 botanical drugs-Korean goat's beard, Cirsium tanakae, Basil-with caffeic acid as its indicator component. This study aims investigate efficacy SGE-107 treating halitosis patients with mild gastrointestinal symptoms.

Seapolynol (SN) is a polyphenol mixture derived from Ecklonia cava. We evaluated the effects of SN on lipid accumulation in adipocytes, zebrafish, and mice. effectively inhibited three experimental models by suppressing adipogenic factors. Triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (DGAT1) GPAT3 were also downregulated SN. This SN-induced inhibition factors was shown to be due regulatory effect early factors; expression Krueppel-like factor 4 (KLF4), KLF5,...

Background: Total ankle arthroplasty (TAA) has higher complication and failure rates compared to other surgical joint replacement procedures despite technological advances. This study aimed find the long-term survivability of TAA procedure identify patient risk factors for with one largest cohorts patients in literature. Methods: retrospective cohort involving cases between 2007 2018 analyzed who received an index primary Korea. A total 5619 were included final analysis. The was defined as...

Excessive alcohol consumption is one of the significant causes morbidity and mortality worldwide. Alcohol oxidized to toxic carcinogenic acetaldehyde by dehydrogenase (ADH) further a non-toxic acetate aldehyde (ALDH). Emerging evidence shows that Lactobacillus Bifidobacterium species encode (ALDH) mediate metabolism, respectively. This study involves supplementation probiotic mixture in humans assessed their effects on metabolism. Here, twenty-seven wild types (ALDH2*1/*1) same number...

Caffeine is white crystalline xanthine alkaloid and found in the seeds, coffee plant leaves of tea bush. In this study, we determined whether caffeine exerts anti‐inflammatory effects on lipopolysaccharide (LPS)‐induced inflammation RAW264.7 cells. To examine LPS‐induced inflammation, RAW 264.7 cells were treated with various concentrations presence or absence LPS. Our data showed that decreased inflammatory mediator, nitric oxide (NO). treatment also reduced expression pro‐inflammatory...

Moutan cortex radicis (MCR), the root bark of Paeonia suffruticosa, has been widely used as a traditional herb. In this study, we evaluated whether MCR extract and two active compounds bark, paeoniflorin (paeo) oxypaeoniflorin (oxypaeo), alleviate lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 cells they controlled TLR signaling pathway. were treated with or presence absence LPS. The inhibited LPS-stimulated nitric oxide (NO) production inducible synthase (iNOS) gene...

Abstract Patients with Parkinson’s disease, especially often combined osteoporosis, have higher risk of osteoporotic fracture. However, large cohort study assessing the preventive effect bisphosphonates for fracture on patients disease is scarce. This retrospective included nearly whole population South Korea during 2002 to 2018 from national patient database National Health Insurance Service. Of 608,202 a total 7,335 were selected index regression model and 5,806 further landmark one-year...

Background: Hallux valgus is a prevalent foot deformity conventionally treated with open surgical techniques, which carry risk of complications due to extensive soft tissue dissection. Minimally invasive surgeries (MISs) as alternatives offer comparable outcomes, reduced pain, and faster recovery; however, their challenges include the shortening first metatarsal. This study aimed assess efficacy our modified MIS hallux correction technique investigate factors that affect metatarsal...

구제역은 전염성이 높고 치명적 결과를 유발하는 우제류 전염병이며, 2010/2011년도에 국내에서 발생한 구제역 (2010/2011 구제역)은 사회 및 경제적으로 국가에 재난 수준의 손실을 끼쳤다. 따라서 국가적 차원에서 구제역의 예방과, 발병 시 피해를 줄이려는 많은 노력을 하고 있다. 이러한 노력의 하나로 전염 현상을 확률적으로 모형화하고 이해하려는 노력이 필요하다. 영국에서 2001년 그 규모와 피해가 막대하여, 영국에서는 다양한 확률적 모형으로 전파 현상에 대한 이해를 통하여 미래의 발생에 대비하려는 연구가 이루어져 왔다. 그러나 2010/2011 구제역에 대하여는 모형을 활용한 미미한 편이다. 본 연구에서는 대하여 시간-공간 확률 SIR 확률모형을 가정하고 시간과 공간에 따르는 고찰한다. 농림수산검역검사본부에서 발표한 감염데이터와 통계청의 전국농가센서스 자료의 일부인 전체 농가의 데이터가 연구의 분석에 필요한 정도로 상세하지 않으므로 추정 보정작업을 데이터를...

Aloe vera is a functional food with various pharmacological functions, including an immune-modulating effect. Until now, A. has never been studied as adjuvant in influenza vaccine, and its effects on upper respiratory tract infection (URI) are unknown.The objective of our study was to investigate the effect processed gel (PAG) immunogenicity quadrivalent inactivated vaccine URI healthy adults.A randomized, double-blind, placebo-controlled clinical trial performed.This conducted 100 adults at...

In the present study, we examined beneficial effect of Ecklonia cava-derived polysaccharide (ECAP), which is residual product after bioactive polyphenol isolation form cava, on neurotoxicity and oxidative stress in hydro peroxide-treated human microglia HMO6 cells. We sought that ECAP inhibited expression p53 Bcl-2 peroxide-induced dramatically suppressed cleaved caspase-3 Moreover, observed peroxide stimulated glucose-6-phosphate dehydrogenase (G6PDH) its downstream target NADPH oxidase 4...

Luteolin is a plant flavone and most often found leaves. In this study, we determine whether luteolin prevents palmitic acid‐induced hepatic steatosis by regulating ER stress in HepG2 cells, human hepatocyte cell line. To examine the effects of on steatosis, cells were treated with low dose high presence or absence acid. We indicated acid induced cells. Palmitic increased lipid accumulation via stimulated SREBP protein level phosphorylation ACC. Also, acid‐stimulated observed apoptosis...

고춧가루에 포함된 씨의 함량은 고춧가루 품질에 영향을 미치는 중요한 요인 중의 하나이다. 본 연구에서는 국내에서 유통되는 고춧가루의 고추씨 혼입 여부 및 혼입량을 판별할 수 있는 분석법을 개발하기 위하여 혼입량에 따른 무기원소와 지방산 조성을 분석한 자료와 정준 판별분석법을 활용하여 예측할 판별함수를 도출하고, 이들 판별함수의 대한 판별력을 평가하였다. 국내산 5점과 중국산 5점 등 총 10점의 고추를 이용하여 고추씨가 과피 대비 0, 10, 20, 30, 40, 50, 60, 70, 80, 90, 100 w/w% 수준으로 첨가된 시료 110점을 제조하였다. 시료에서 11종의 15종의 지방산이 검출되었다. 무기원소 중 P와 S의 평균 혼입량과 유의적인(P<0.01) 양의 상관관계를 나타냈지만, Ca의 함량과 혼입량 간에는 음의 상관관계가 나타났다. 18:2n-6의 나타낸 반면, 18:1n-7과 18:3n-3의 나타냈다. 판별분석 결과 검출된 26종의 성분 Ca, P, S...