A5100661992- Adipokines, Inflammation, and Metabolic Diseases
- Seaweed-derived Bioactive Compounds
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Metabolism, Diabetes, and Cancer
- Autophagy in Disease and Therapy
- Diet and metabolism studies
- Prostate Cancer Treatment and Research
- Tuberculosis Research and Epidemiology
- Morinda citrifolia extract uses
- Lipid metabolism and biosynthesis
- Phytochemicals and Antioxidant Activities
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Glioma Diagnosis and Treatment
- Ubiquitin and proteasome pathways
- Mycobacterium research and diagnosis
- Ginseng Biological Effects and Applications
- RNA modifications and cancer
- Nutrition and Health in Aging
- Melanoma and MAPK Pathways
- Prenatal Substance Exposure Effects
- Folate and B Vitamins Research
- Advanced Numerical Analysis Techniques
- Heat shock proteins research
Cedars-Sinai Medical Center
2021-2024
Seoul National University Bundang Hospital
2021-2024
Ewha Womans University
2024
Korea Institute of Radiological and Medical Sciences
2019-2020
CHA University
2015-2020
Chonnam National University
2018-2019
Samsung Medical Center
2019
Sungkyunkwan University
2019
Hanyang University
2014-2016
Seonam University
2015
Kaempferol is a flavonoid present in<italic>Kaempferia galanga</italic>and<italic>Opuntia ficus indica</italic>var.<italic>saboten</italic>.
Abstract Despite progress in prostate cancer (PC) therapeutics, distant metastasis remains a major cause of morbidity and mortality from PC. Thus, there is growing recognition that preventing or delaying PC holds great potential for substantially improving patient outcomes. Here we show receptor-interacting protein kinase 2 (RIPK2) clinically actionable target inhibiting metastasis. RIPK2 amplified/gained ~65% lethal metastatic castration-resistant Its overexpression associated with disease...
Obesity is a major threat to public health, and it strongly associated with insulin resistance fatty liver disease. Here, we demonstrated that administration of Lactobacillus acidophilus NS1 (LNS1) significantly reduced obesity hepatic lipid accumulation, concomitant improvement in sensitivity, high-fat diet (HFD)-fed mice. Furthermore, LNS1 inhibited the effect HFD feeding on SREBP-1c PPARα signaling pathways lipogenesis an increase acid oxidation ex vivo livers from HFD-fed These effects...
Browning of white adipose tissue (WAT) is currently considered a potential therapeutic strategy to treat diet-induced obesity. While some probiotics have protective effects against obesity, the role in browning has not been explored. Here, we show that administration probiotic bacterium Lactobacillus amylovorus KU4 (LKU4) mice fed high-fat diet (HFD) enhanced mitochondrial levels and function, as well thermogenic gene program (increased Ucp1, PPARγ, PGC-1α expression decreased RIP140...
Abstract Glioblastoma is frequently associated with TP53 mutation, which linked to a worse prognosis and response conventional treatments (chemoradiotherapy). Therefore, targeting promising strategy overcome this poor therapeutic response. Tumor-treating fields (TTFields) are recently approved treatment for newly diagnosed glioblastoma, involves direct application of low-intensity, intermediate-frequency alternating electric the tumor, thereby offering local tumor-killing effect. However,...
A uniform prognostic marker is needed for nontuberculous mycobacterial pulmonary disease (NTM-PD) due to the diverse clinical course. We aimed seek utility of BACES score, originally derived predict all-cause mortality, various outcomes. To calculate one point was given each following factors: body mass index < 18.5 kg/m2, age ≥ 65 years, presence cavities, elevated erythrocyte sedimentation rate, or male sex. The study included 681 patients, whom 97 (14.2%), 189 (27.7%), 192 (28.2%), 143...
Colorectal cancer (CRC) is a major cause of mortality that can be treated effectively with chemotherapy and radiotherapy, although resistance to these therapeutic modalities often occurs. Tumor-treating fields (TTFields) block tumor growth by selectively impairing cell division. In this study, we investigated the mechanism which 5-fluorouracil (5-FU) sensitizes cells TTFields. Human HCT116 SW480 CRC were 5-FU and/or TTFields, characterized in vitro terms viability, apoptosis through reactive...
Seapolynol (SN) is a polyphenol mixture derived from Ecklonia cava. We evaluated the effects of SN on lipid accumulation in adipocytes, zebrafish, and mice. effectively inhibited three experimental models by suppressing adipogenic factors. Triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (DGAT1) GPAT3 were also downregulated SN. This SN-induced inhibition factors was shown to be due regulatory effect early factors; expression Krueppel-like factor 4 (KLF4), KLF5,...
Obesity results from an imbalance between energy intake and expenditure, in which excess fat is stored as triglycerides (TGs) white adipocytes. Recent studies have explored the anti-obesity effects of certain edible phytochemicals, suppress TG accumulation stimulate a brown adipocyte-like phenotype Gomisin N (GN) important bioactive component Schisandra chinensis, woody plant endemic to Asia. GN has antioxidant, anti-inflammatory hepatoprotective vivo vitro. However, lipid metabolism...
In this study, we evaluated whether Hesperetin (HT), which is citrus flavonoids, affects lipid accumulation and reactive oxygen species (ROS) production during adipogenesis underlying molecular actions. To end, cells were incubated in the presence or absence of HT adipocyte differentiation. Oil Red O (ORO) staining showed that was inhibited by 63% at a concentration 25 μM compared to control. Additionally, treatment with expression adipogenic factors lipogenic factors. Moreover, our results...
Osteosarcoma (OS) originates from osteoid bone tissues and is prone to metastasis, resulting in a high mortality rate. Although several treatments are available for OS, an effective cure does not exist most patients with advanced OS. Zoledronic acid (ZOL) third-generation bisphosphonate that inhibits osteoclast-mediated resorption has shown efficacy treating metastases various types of solid tumors. Here, we sought clarify the mechanisms through which ZOL OS cell proliferation. treatment...
The prognosis of metastatic osteosarcoma (OS) remains poor with a <20% survival rate, particularly in cases distant (non-lung) metastases. Tumor-treating field (TTF) therapy is novel electric field-based treatment that causes metaphase arrest and tumor cell death, the advantage reduced side effects compared to radiation chemotherapy. TTF shows promise glioblastoma other solid tumors; however, few studies have examined its potential osteosarcoma. Therefore, we explored mechanism...
The aim of this study was to determine the possible prognostic factors in patients with uterine leiomyosarcoma (LMS).This retrospectively investigated 50 LMS treated at Samsung Medical Center between 2001 and 2017. To analyze significance for recurrence-free survival (RFS), overall (OS), after recurrence, log-rank test Cox proportional hazards model were used univariate multivariate analysis.Of patients, 30 (60.0%) experienced recurrence 16 (32.0%) died within a median follow-up period 21...
Abstract The poor therapeutic efficacy of non-small cell lung cancer (NSCLC) is partly attributed to the acquisition chemoresistance. To investigate mechanism underlying this resistance, we examined potential link between kinesin light chain 4 (KLC4), which have previously reported be associated with radioresistance in NSCLC, and sensitivity chemotherapy human lines. KLC4 protein levels cells correlated degree chemoresistance cisplatin treatment. Furthermore, silencing enhanced cytotoxic...
Abstract Prostate cancer (PC) is a major health and economic problem in industrialized countries, yet our understanding of the molecular mechanisms PC progression drug response remains limited. Accumulating evidence showed that certain E3 ubiquitin ligases such as SIAH2, RNF7, SPOP play important roles development progression. However, other E3s remain largely unexplored. Through an integration analysis clinical genomic transcriptomic profiles tumors, this study identified UBR5 top...
Radiotherapy using high linear energy transfer (LET) radiation results in effectively killing tumor cells while minimizing dose (biological effective) to normal tissues block toxicity. It is well known that LET leads lower cell survival per absorbed than low radiation. High-linear neutron treatment induces autophagy cells, but its precise mechanisms osteosarcoma are unknown. Here, we investigated this mechanism and the underlying signaling pathways. Autophagy induction was examined...
Research on vitamin D in patients with nontuberculous mycobacterial (NTM) pulmonary disease (PD) is limited. We aimed to compare the parameters of NTM-PD those a healthy control group, and assess possible predictive markers for clinical response. prospectively enrolled 53 between January 2014 December 2016. The data indices, including total, free, bioavailable 25-(OH)D, binding protein (VDBP) genotyping, were measured at baseline six months after enrollment. An external dataset 226 controls...
<title>Abstract</title> Background and objective Acute severe exacerbation of chronic obstructive pulmonary disease (COPD) is related to high mortality; however, a robust blood biomarker for COPD has not been established. Impaired clearance apoptotic cells possible pathogenesis development. We evaluated the clinical utility serum cell viability as predictive exacerbation. Methods Using from patients with stable COPD, was analyzed lactate dehydrogenase (LDH) assay. The were divided into low...