A5101422696- Gastrointestinal Tumor Research and Treatment
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Prenatal Substance Exposure Effects
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Cancer Genomics and Diagnostics
- Radiation Therapy and Dosimetry
- FOXO transcription factor regulation
- Pancreatic and Hepatic Oncology Research
- Traumatic Brain Injury Research
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Effects of Radiation Exposure
- Cancer survivorship and care
- Colorectal Cancer Treatments and Studies
- Mast cells and histamine
- Cancer-related molecular mechanisms research
- Childhood Cancer Survivors' Quality of Life
- Cardiovascular Syncope and Autonomic Disorders
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Arrest and Resuscitation
Korea University of Science and Technology
2021
Korea Institute of Radiological and Medical Sciences
2015-2021
Enhancing the radioresponsiveness of colorectal cancer (CRC) is essential for local control and prognosis. However, consequent damage to surrounding healthy cells can lead treatment failure. We hypothesized that short‑chain fatty acids (SCFAs) could act as radiosensitizers cells, allowing administration a lower safer dose radiation. To test this hypothesis, responses three‑dimensional‑cultured organoids, derived from CRC patients, radiotherapy, well effects combined radiotherapy with SCFAs...
Abstract Radioresistance is a challenge in the treatment of esophageal squamous cell carcinoma (ESCC). MicroRNAs (miRNAs) are known to play an important role functional modification cancer cells and recent studies have reported miRNA-mediated radiotherapy resistance. However, further research necessary reveal regulation mechanisms, strategies using miRNA yet be established for ESCC. We compared expression profiles ESCC parental (TE-4) acquired radioresistance (TE-4R) lines microarray...
Patient-derived tumor organoids closely resemble original patient tumors. We conducted this co-clinical trial with treatment-naive rectal cancer patients and matched patient-derived to determine whether a correlation exists between experimental results obtained after irradiation in organoids. Between November 2017 March 2020, we prospectively enrolled 33 who were diagnosed mid-to-lower adenocarcinoma based on endoscopic biopsy findings. constructed prediction model through machine learning...
Colorectal cancer (CRC) is a major cause of mortality that can be treated effectively with chemotherapy and radiotherapy, although resistance to these therapeutic modalities often occurs. Tumor-treating fields (TTFields) block tumor growth by selectively impairing cell division. In this study, we investigated the mechanism which 5-fluorouracil (5-FU) sensitizes cells TTFields. Human HCT116 SW480 CRC were 5-FU and/or TTFields, characterized in vitro terms viability, apoptosis through reactive...
Tumor radioresistance is a major reason for decreased efficiency of cancer radiation therapy. Although number factors involved in have been identified, the molecular mechanisms underlying esophageal squamous cell carcinoma (ESCC) not elucidated. In this study, we investigated role oncogenic protein tyrosine kinase 7 (PTK7) resistance ESCC to lines with high PTK7 expression were more refractive than those low levels. radioresistant cells, knockdown by specific siRNAs survival irradiated cells...
Esophageal squamous cell carcinoma (ESCC), the most common subtype of esophageal cancer in East Asian countries, is still associated with a poor prognosis because high frequency lymph node metastasis and invasion. In our previous study, we identified novel methylation gene, cysteine dioxygenase 1 (CDO1) that involved conversion to sulfinate, plays key role taurine biosynthesis. Decreased expression CDO1 was observed ESCC lines tumors derived from patient tissues, silencing could be reversed...
LARC patients were sorted according to their radio-responsiveness and patient-derived organoids established from the respective cancer tissues. Expression profiles for each group obtained using RNA-seq. Biological bioinformatic analysis approaches used in deciphering genes pathways that participate radio-resistance of LARC. Thirty candidate encoding proteins involved radio-responsiveness–related pathways, including immune system, DNA repair cell-cycle control, identified. Interestingly, one...
Backgrounds/Aims Cysteine dioxygenase type 1 (CDO1) acts as a tumor suppressor and is silenced by promoter methylation in various malignancies. The relationship between the CDO1 status hepatocellular carcinoma (HCC) tumorigenesis was evaluated. Methods Using HCC cell line (SNU423), an vitro demethylation study performed to confirm whether causes down-regulation. SNU423 cells transfected with function compared that of naïve cells. An vivo using immunohistochemical staining specimens were...
Radiotherapy is a leading treatment for various types of cancer. However, exposure to high-dose ionizing radiation causes acute gastrointestinal injury and syndrome. This has significant implications human health, therefore, radioprotection major area research. Radiation induces the loss intestinal stem cells; hence, protection cells expressing LGR5 (a marker epithelial cells) key strategy prevention radiation-induced injury. In this study, we identified valproic acid (VPA) as potent...
MicroRNAs (miRNAs/miRs) are a class of small non‑coding RNAs that play pivotal roles in cancer physiology as important epigenetic regulators gene expression. Several miRNAs have been previously discovered regulate the proliferation colorectal (CRC) cell line HCT116. In present study, one these miRNAs, miR‑5191, was characterized tumor suppressor CRC cells. Transfection with miR‑5191 led to significant decrease proliferation, invasiveness, sphere‑forming ability and organoid growth,...
Preclinical evaluation models have been developed for precision medicine, with patient-derived xenograft (PDXs) and organoids (PDOs) attracting increasing attention. However, each of these has application limitations. In this study, an advanced model was established used drug screening. PDO endothelial colony-forming cells (ECFCs) were cotransplanted in NRGA mice (PDOXwE) to prepare the model, which could also be subcultured Balb/c nude mice. Our DNA sequencing analysis immunohistochemistry...
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