A5067673359- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Prenatal Substance Exposure Effects
- Epigenetics and DNA Methylation
- Lung Cancer Treatments and Mutations
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Liver Disease and Transplantation
- Cancer-related molecular mechanisms research
Dongnam Institute of Radiological & Medical Sciences
2017-2024
Backgrounds/Aims Cysteine dioxygenase type 1 (CDO1) acts as a tumor suppressor and is silenced by promoter methylation in various malignancies. The relationship between the CDO1 status hepatocellular carcinoma (HCC) tumorigenesis was evaluated. Methods Using HCC cell line (SNU423), an vitro demethylation study performed to confirm whether causes down-regulation. SNU423 cells transfected with function compared that of naïve cells. An vivo using immunohistochemical staining specimens were...
The clinical implication of lymph node (LN) dissection intrahepatic cholangiocarcinoma (ICCA) is still controversial, and LN metastasis (LNM) based on tumor site has not been confirmed yet.Patients who underwent curative-intent surgery at 10 tertiary referral centers were identified divided into peripheral (PP) near second confluence level (NC) groups the basis distance from oncological outcomes compared.Of 179 patients, 121 patients with LND NC (n = 89) PP 32) 4.5 cm confluence. group...
Extrahepatic metastasis (EHM) from hepatocellular carcinoma (HCC) occurs in 10%-15% of cases following initial treatment. The most frequent sites EHM are the lung, lymph nodes, and bone. Gastrointestinal or brain HCC is rarely reported. Here, we report a rare case concurrent metastases to stomach, colon, brain.A 72-year-old male with history alcohol induced presented multiple intrahepatic recurrences tumorous lesions stomach ascending colon. Three years earlier, he underwent right...
Hilar cholangiocarcinomas (HLC) are known to have worse prognoses than mid-to-distal (CBDC). We analyzed the clinical results of surgical resections for extrahepatic validate differences in HLC and CBDC.Two hundred eighty-one patients underwent curative at Department Surgery Korea Cancer Center Hospital. Among them, we T2 T3 compared between those with (n=74) CBDC (n=65).The rate R1 was significantly higher (31.1% vs 12.3%, p=0.006). The overall survival T2/T3 lower group (24.5% 51.7,...
Intrahepatic recurrence is frequent result after hepatectomy for hepatocellular carcinoma (HCC). We analyzed the clinical results of patients who had intrahepatic recurrences HCC curative surgical resections.From January 2009 to December 2016, 320 underwent resection in department Surgery, Korea Cancer Center Hospital. After resection, 155 suffered during follow-up period. Among them, 122 only initially, were included this retrospective study. about period surgery, treatment methods recurred...
Downstaging of hepatocellular carcinoma (HCC) is typically defined as the reduction in size or number viable tumors through locoregional therapy (LRT), aiming to meet established criteria for liver transplantation (LT). According Barcelona Clinic Liver Cancer (BCLC) staging system, a subgroup patients with BCLC-B may benefit most from downstaging therapies. The United Network Organ Sharing protocol identifies potential candidates by setting out 'inclusion criteria' and defining 'successful...
Hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) have a extremely poor prognosis. According to the Barcelona Clinic Liver Cancer guideline, sorafenib is standard therapy in this situation, but many clinicians still select locoregional (LRT) such as transarterial therapy, external beam radiation (EBRT), even surgical resection (SR) or combination of LRTs because survival improvement by unsatisfactory. Based on recent meta-analysis and prospective study,...