A5085143238- Advanced Sensor and Energy Harvesting Materials
- Tactile and Sensory Interactions
- Bacterial Identification and Susceptibility Testing
- Advanced Chemical Sensor Technologies
- Microfluidic and Capillary Electrophoresis Applications
- Biosensors and Analytical Detection
- Non-Invasive Vital Sign Monitoring
- Innovative Microfluidic and Catalytic Techniques Innovation
- Mycobacterium research and diagnosis
- Antimicrobial Resistance in Staphylococcus
- Analytical Chemistry and Sensors
- Antibiotic Resistance in Bacteria
- Thermoregulation and physiological responses
- Advanced biosensing and bioanalysis techniques
- Clostridium difficile and Clostridium perfringens research
- Conducting polymers and applications
- Cell Image Analysis Techniques
- 3D Printing in Biomedical Research
- Face and Expression Recognition
- Modular Robots and Swarm Intelligence
- Cholinesterase and Neurodegenerative Diseases
- Nanomaterials and Printing Technologies
- Advanced Materials and Mechanics
- Respiratory Support and Mechanisms
- PARP inhibition in cancer therapy
Ajou University
2022-2025
Northwestern University
2017-2021
Kookmin University
2019-2021
Government of the Republic of Korea
2020
Seoul National University
2012-2018
Seoul National University Hospital
2017-2018
Gyeongsang National University
2011-2014
Institute for Basic Science
2012-2014
Inha University
2002
Battery-free, wireless microfluidic/electronic system for multiparameter sweat analysis.
Real-time measurements of the total loss sweat, rate sweating, temperature and concentrations electrolytes metabolites in sweat can provide important insights into human physiology. Conventional methods use manual collection processes (e.g., absorbent pads) to determine lab-based instrumentation analyze its chemical composition. Although such schemes yield accurate data, they cannot be used outside laboratories or clinics. Recently reported wearable electrochemical devices for sensing bypass...
An antimicrobial susceptibility test rapidly identifies bacterial response to drugs based on imaged morphology of single cells.
Systems for time sequential capture of microliter volumes sweat released from targeted regions the skin offer potential to enable analysis temporal variations in electrolyte balance and biomarker concentration throughout a period interest. Current methods that rely on absorbent pads taped do not ease use needed quantitative tracking; emerging classes electronic wearable systems directly manage sweat‐induced fluid flows sample isolation. Here, thin, soft, “skin‐like” microfluidic platform is...
Waterproof epidermal microfluidics enable collection and analysis of sweat during aquatic exercise.
Significance Continuous, cuffless, and noninvasive blood pressure monitoring by measuring the pulse wave velocity is generally considered to be a promising technique for measurements. Previously reported relations between relation involve unrealistic assumptions that do not hold human arteries, also rely on empirical expressions without any theoretical basis. Here, an analytical model such or established yield has general utility future work in continuous, monitoring.
Passive sweat collection and colorimetric analysis.
A wearable microfluidic system and smartphone optics module enabled <italic>in situ</italic> analysis of sweat.
Capabilities for continuous monitoring of pressures and temperatures at critical skin interfaces can help to guide care strategies that minimize the potential pressure injuries in hospitalized patients or individuals confined bed. This paper introduces a soft, skin-mountable class sensor system this purpose. The design includes pressure-responsive element based on membrane deflection battery-free, wireless mode operation capable multi-site measurements strategic locations across body. Such...
Sepsis is one of the major causes death in US, necessitating rapid treatment with proper antibiotics. Conventional systems for antibiotic susceptibility testing (AST) take far too long (16–24 h) timely sepsis. This because they rely on measuring optical density, which relates to bacterial growth, determine minimal inhibitory concentrations (MICs) relevant Thus, there a desperate need more improved and AST (RAST) systems. The RAST system can also reduce growing number clinical problems that...
Abstract This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin‐mounted microfluidic devices designed to capture, store, chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow an inlet location into a collection isolated reservoirs, in well‐defined sequence. Analysis these reservoirs involves color responsive indicator chloride concentration with formulation...
Abstract Wearable monitoring systems provide valuable insights about the state of wellness, performance, and progression diseases. Although conventional wearable have been effective in measuring a few key biophysical markers, they offer limited into biochemical activity are otherwise cumbersome ambulatory modes use, relying on wired connections, mechanical straps, bulky electronics. Recent advances skin‐interfaced microfluidics, stretchable/flexible electronics, mechanics created new with...
During periods of activity, sweat glands produce pressures associated with osmotic effects to drive liquid the surface skin. The magnitudes these may provide insights into physiological health, intensity physical exertion, psychological stress factors and/other information interest, yet they are currently unknown due absence means for non-invasive measurement. This paper introduces a thin, soft wearable microfluidic system that mounts onto skin enable precise and routine measurements...
Abstract For the timely treatment of patients with infections in bloodstream and cerebrospinal fluid, a rapid antimicrobial susceptibility test (AST) is urgently needed. Here, we describe direct testing (dRAST) system, which can determine bacteria from positive blood culture bottle (PBCB) six hours. The sample directly mixed agarose inoculated into micropatterned plastic microchip lyophilized antibiotic agents. Using microscopic detection bacterial colony formation agarose, total time to...
Abstract Sweat excretion is a dynamic physiological process that varies with body position, activity level, environmental factors, and health status. Conventional means for measuring the properties of sweat yield accurate results but their requirements sampling analytics do not allow use in field. Emerging wearable devices offer significant advantages over existing approaches, each has drawbacks associated bulk weight, inability to quantify volumetric rate loss, robustness, and/or inadequate...
The concentration of chloride in sweat remains the most robust biomarker for confirmatory diagnosis cystic fibrosis (CF), a common life-shortening genetic disorder. Early via quantitative assessment allows prompt initiation care and is critically important to extend life expectancy improve quality life. collection analysis using conventional wrist-strapped devices iontophoresis can be cumbersome, particularly infants with fragile skin, who often have insufficient production. Here, we...
Recently introduced classes of thin, soft, skin-mounted microfluidic systems offer powerful capabilities for continuous, real-time monitoring total sweat loss, rate and biomarkers. Although these technologies operate without the cost, complexity, size, weight associated with active components or power sources, rehydration events can render previous measurements irrelevant detection anomalous physiological events, such as high requires user engagement to observe colorimetric responses. Here...
Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of 5-FU resistance. Thymidylate synthase (TS) is a target protein 5-FU, and elevated TS lowers CRC cells. Here, we tested efficacy several candidate phytochemicals against human CRC-derived HCT116 cells expressing wild-type tumor suppressor P53 HT29 mutant P53. Among them, found that apigenin enhanced inhibitory...
Soft microfluidics with reference reactions enable quantitative sweat ammonia–ethanol assay.
Comprehensive analysis of sweat chemistry provides noninvasive health monitoring capabilities that complement established biophysical measurements such as heart rate, blood oxygenation, and body temperature. Recent developments in skin-integrated soft microfluidic systems address many challenges associated with standard technologies collection analysis. However, recording time-dependent variations composition requires bulky electronic power sources, thereby constraining form factor, cost,...