A5083330692- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Advanced biosensing and bioanalysis techniques
- Modular Robots and Swarm Intelligence
- Electrowetting and Microfluidic Technologies
- Nanofabrication and Lithography Techniques
- Microfluidic and Bio-sensing Technologies
- Micro and Nano Robotics
- Advanced Materials and Mechanics
- 3D Printing in Biomedical Research
- Bacterial Identification and Susceptibility Testing
- Biosensors and Analytical Detection
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Photonic Crystals and Applications
- Alzheimer's disease research and treatments
- Photonic and Optical Devices
- Advanced Biosensing Techniques and Applications
- DNA and Biological Computing
- T-cell and B-cell Immunology
- Advanced Sensor and Energy Harvesting Materials
- Cancer Cells and Metastasis
- Monoclonal and Polyclonal Antibodies Research
- Additive Manufacturing and 3D Printing Technologies
- Gold and Silver Nanoparticles Synthesis and Applications
Seoul National University
2016-2025
Seoul National University Hospital
2016-2024
Seoul Semiconductor (South Korea)
2023
Seoul National University of Education
2022
Systems Research Institute
2020
Government of the Republic of Korea
2017-2020
Kyung Hee University
2012-2018
University of Illinois Urbana-Champaign
2018
Biomedical Research Institute
2018
CHA Gangnam Medical Center
2016-2018
An unclonable, fingerprint-mimicking anti-counterfeiting strategy is presented that encrypts polymeric particles with randomly generated silica film wrinkles. The wrinkle codes are as highly unique human fingerprints and technically irreproducible. Superior to previous physical unclonable functions, tunable on demand generable various geometries. Reliable authentication of real-world products have these microfingerprints demonstrated using optical decoding methods. As a service our authors...
An antimicrobial susceptibility test rapidly identifies bacterial response to drugs based on imaged morphology of single cells.
A QR-coded microtaggant for the anti-counterfeiting of drugs is proposed that can provide high capacity and error-correction capability. It fabricated lithographically in a microfluidic channel with special consideration island patterns QR Code. The incorporated drug capsule (“on-dose authentication”) be read by simple smartphone Code reader application when removed from washed free drug.
New ways of detecting low concentrations analytes , which could be used as part integrated on‐chip devices, are offered by surface‐enhanced Raman‐scattering substrates fabricated on the nanoscale. The ability metal surfaces to amplify a signal (see Figure) is combined with an enlarged substrate surface area, allowing orders magnitude enhancement for detection rhodamine 6G and adenine.
Magnetochromatic microspheres have been fabricated through instant assembly of superparamagnetic (SPM) colloidal particles inside emulsion droplets UV curable resin followed by an immediate curing process to polymerize the and fix ordered structures. When dispersed in liquid droplets, Fe3O4@SiO2 core/shell self-organize under balanced interaction repulsive attractive forces form one-dimensional chains, each which contains periodically arranged diffracting visible light displaying...
Sepsis is one of the major causes death in US, necessitating rapid treatment with proper antibiotics. Conventional systems for antibiotic susceptibility testing (AST) take far too long (16–24 h) timely sepsis. This because they rely on measuring optical density, which relates to bacterial growth, determine minimal inhibitory concentrations (MICs) relevant Thus, there a desperate need more improved and AST (RAST) systems. The RAST system can also reduce growing number clinical problems that...
The authors propose an optofluidic maskless lithography technique that can dynamically synthesize free-floating polymeric microstructures inside microfluidic channels by selectively polymerizing photocurable resin with high-speed two-dimensional spatial light modulators. combination of programable optical projection and devices allows one to precisely control the timing location photopolymerization process for microstructure fabrication. Real-time generation microparticles various shapes,...
We extensively study the relationships between single-molecule surface-enhanced Raman scattering (SMSERS) intensity, enhancement factor (EF) distribution over many particles, interparticle distance, particle size/shape/composition and excitation laser wavelength using single-particle AFM-correlated measurement method theoretical calculations. Two different single-DNA-tethered Au–Ag core–shell nanodumbbell (GSND) designs with an engineerable nanogap were used in this study: GSND-I various...
We have investigated the focusing and dynamics of non-spherical polymeric particles in microfluidic flows at finite Reynolds number. The rotational diameter, Dmax, a particle, regardless its cross-sectional shape, was found to determine final focused position, except for case asymmetric disks. Additionally, elongated with larger Dmax exhibited longer residence times horizontal orientation than those smaller Dmax. These findings inform approaches hydrodynamically control shaped barcoded...
Abstract For the timely treatment of patients with infections in bloodstream and cerebrospinal fluid, a rapid antimicrobial susceptibility test (AST) is urgently needed. Here, we describe direct testing (dRAST) system, which can determine bacteria from positive blood culture bottle (PBCB) six hours. The sample directly mixed agarose inoculated into micropatterned plastic microchip lyophilized antibiotic agents. Using microscopic detection bacterial colony formation agarose, total time to...
Stereotypic antibody clonotypes exist in healthy individuals and may provide protective immunity against viral infections by neutralization. We observed that 13 of 17 patients with COVID-19 had stereotypic variable heavy chain (V
Abstract DNA-based data storage has emerged as a promising method to satisfy the exponentially increasing demand for information storage. However, practical implementation of remains challenge because high cost writing through DNA synthesis. Here, we propose use degenerate bases encoding characters in addition A, C, G, and T, which augments amount that can be stored per length sequence designed (information capacity) lowering synthesis storing unit data. Using proposed method, experimentally...
We report the rapid formation of photonic crystal structures by assembly uniform nonmagnetic colloidal particles in ferrofluids using external magnetic fields. Magnetic manipulation with size down to a few hundred nanometers, suitable building blocks for producing crystals band gaps located visible regime, has been difficult due their weak dipole moment. Increasing moment holes limited instability toward aggregation at high concentration or under strong field. By taking advantage superior...
We propose a method for high-throughput generation of 3D microstructures using membrane-mounted microfluidic channel. Utilizing an optofluidic maskless lithography system, photopolymerized are fabricated in layer-by-layer fashion with the thickness each layer controlled by deformation membrane. The combination low numerical aperture optical systems photopolymerization and soft membrane height control allows large area projection high vertical resolution, overcoming trade-off between...