A5023474900- Reproductive System and Pregnancy
- Genomics, phytochemicals, and oxidative stress
- Zebrafish Biomedical Research Applications
- Endometriosis Research and Treatment
- Environmental Toxicology and Ecotoxicology
- Reproductive Biology and Fertility
- MicroRNA in disease regulation
- Pesticide Exposure and Toxicity
- Reproductive Physiology in Livestock
- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Endoplasmic Reticulum Stress and Disease
- Protease and Inhibitor Mechanisms
- Apelin-related biomedical research
- Intraperitoneal and Appendiceal Malignancies
- Sperm and Testicular Function
- Carcinogens and Genotoxicity Assessment
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Mitochondrial Function and Pathology
- Pesticide and Herbicide Environmental Studies
- Peroxisome Proliferator-Activated Receptors
- Cancer Mechanisms and Therapy
Sungkyunkwan University
2021-2025
Sir Charles Gairdner Hospital
2024
The University of Western Australia
2024
Kookmin University
2019-2022
Seoul National University
2010-2022
Bridge University
2022
McMaster University
2021
Catholic Kwandong University
2017-2019
Medtronic (United States)
2019
Food & Nutrition
2019
A worldwide outbreak of severe acute respiratory syndrome (SARS) has been associated with exposures originating from a single ill health care worker Guangdong Province, China. We conducted studies to identify the etiologic agent this outbreak.We received clinical specimens patients in seven countries and tested them, using virus-isolation techniques, electron-microscopical histologic studies, molecular serologic assays, an attempt wide range potential pathogens.None previously described...
Abstract Dynamic interactions between organelles are responsible for a variety of intercellular functions, and the endoplasmic reticulum (ER)–mitochondrial axis is recognized as representative interorganelle system. Several studies have confirmed that most proteins in physically tethered sites ER mitochondria, called mitochondria-associated membranes (MAMs), vital intracellular physiology. MAM involved regulation calcium homeostasis, lipid metabolism, mitochondrial dynamics associated with...
ABSTRACT Prostate cancer is the most common in men and second cause of cancer‐related deaths men. Although, various drugs targeting androgen receptor are normally used, patients frequently undergo recurrence disease. To overcome these limitations, natural compounds have been researched for evidence that they suppress progression metastasis cells. In present study, we investigated effects naringenin, a anti‐oxidant flavonoid derived from citrus, on prostate cells (PC3 LNCaP). Results study...
Chrysin is a natural flavone found in numerous plant extracts, honey, and propolis that has multiple biological activities including anti-cancer effects. Understanding of mechanisms mediated response to chrysin cancerous cells may provide novel insight into chemotherapeutic approaches with reduced side effects cancers. In the present study, we investigated functional roles progression prostate cancer using DU145 PC-3 cell lines. The results showed induced apoptosis evidenced by DNA...
Phytosterols have physiological effects and are used as medicines or food supplements. Stigmasterol has shown anticancer against various cancers such hepatoma, cholangiocarcinoma, gall bladder carcinoma, endometrial adenocarcinoma skin, gastric, breast, prostate, cervical cancer. However, there no reports on stigmasterol's ovarian cancer.We investigated the of stigmasterol proapoptotic signals, mitochondrial function, reactive oxygen species production, cytosolic calcium levels in human...
Although effective drugs have been developed, including 5-fluorouracil (5-FU), advanced colorectal cancer (CRC) shows low therapeutic sensitivity resulting from the development of 5-FU resistance. Thymidylate synthase (TS) is a target protein 5-FU, and elevated TS lowers CRC cells. Here, we tested efficacy several candidate phytochemicals against human CRC-derived HCT116 cells expressing wild-type tumor suppressor P53 HT29 mutant P53. Among them, found that apigenin enhanced inhibitory...
Chrysophanol is an anthraquinone compound, mainly isolated from rhubarb, with anti-cancer effects on some types of cancer cells. However, chrysophanol human choriocarcinoma cells are not known. Therefore, the objective this study was to determine (JAR and JEG-3) identify signal transduction cascades activated by chrysophanol. Results present study, showed that decreased cell viability induced apoptosis JEG-3, but JAR cells, in a dose-dependent manner. also increased oxidative stress JEG-3...
Apigenin is a plant‐derived flavonoid having antiproliferative, anti‐inflammatory, and anti‐angiogenic properties in chronic metabolic diseases, cancers. However, the functional role of apigenin remains to be identified human endometriosis that benign inflammatory disease causing infertility, dysmenorrhea, dyspareunia, abdominal or pelvic pain. In present study, we determined effects on two well‐established cell lines (VK2/E6E7 End1/E6E7). reduced proliferation induced cycle arrest apoptosis...
Apigenin is a flavonoid found in parsley, onions, oranges, tea, chamomile, wheat, and sprouts. It has variety of biological properties including anti-oxidant, anti-mutagenic, anti-carcinogenic, anti-inflammatory, anti-proliferative, anti-spasmodic effects. Based on epidemiological case-control studies, apigenin regarded as novel chemotherapeutic agent against various cancer types. However, little known about the effects choriocarcinoma cells. Therefore, we investigated anti-cancer cells (JAR...
Abstract Human umbilical cord mesenchymal stem cells (MSCs) have been reported to improve the migration and invasion of trophoblast cells; however, little is known about whether MSC-derived exosomes exosomal miRNAs can regulate cell properties. In this study, we investigated from amniotic fluid-derived MSC (AF-MSC) could inflammatory response human line HTR8/SVneo. We verified anti-inflammatory effects AF-MSCs on lipopolysaccharide (LPS)-induced found that miR-146a-5p miR-548e-5p in...
Phytosterols, which are present in a variety of foods, exhibit various physiological functions and do not have any side effects. Here, we attempted to identify functional role campesterol regulation oxidative stress by leading cell death ovarian cancer. We investigated the effects on cancer aggregation using three-dimensional (3D) culture human cells. The apoptosis, protein expression, proliferation, cycle, migration these cells were determined unravel underlying mechanism. also whether...