A5014061311- Genomics, phytochemicals, and oxidative stress
- Pesticide Exposure and Toxicity
- Sperm and Testicular Function
- Endometriosis Research and Treatment
- Intraperitoneal and Appendiceal Malignancies
- Endoplasmic Reticulum Stress and Disease
- Carcinogens and Genotoxicity Assessment
- Cancer, Lipids, and Metabolism
- Reproductive Biology and Fertility
- Selenium in Biological Systems
- Bone Tissue Engineering Materials
- Environmental Toxicology and Ecotoxicology
- RNA Interference and Gene Delivery
- Plant chemical constituents analysis
- Advanced Polymer Synthesis and Characterization
- Sirtuins and Resveratrol in Medicine
- Reproductive System and Pregnancy
- Polymer Surface Interaction Studies
- Aldose Reductase and Taurine
- Toxic Organic Pollutants Impact
- Breast Implant and Reconstruction
- Birth, Development, and Health
- Autophagy in Disease and Therapy
- Quantum Electrodynamics and Casimir Effect
- Stress Responses and Cortisol
Chungnam National University
2023-2025
Korea University
2017-2023
Bridge University
2022
Sungkyunkwan University
2022
Seoul National University
2012-2020
Kyungpook National University Hospital
2019
Kyungpook National University
2018
Environmental pollutants, including endocrine disruptors, heavy metals, nanomaterials, and pesticides, have been detected in various ecosystems are of growing global concern. The potential for toxicity to non-target organisms has consistently raised is being studied using animal models. In this review, we focus on pesticides frequently the environment investigate their exposure livestock. Owing reproductive similarities between humans pigs, vitro porcine models such as oocytes, trophectoderm...
Fraxetin is a coumarin scaffold compound extracted from Fraxinus rhynchophylla. It has antioxidant, anti-inflammatory, hepatoprotective, and antifibrotic effects. Furthermore, fraxetin anticancer effects in breast lung cancer. We aimed to evaluate whether activity hepatocellular carcinoma (HCC) cells its underlying mechanism. demonstrated the of HCC cell lines Huh7 Hep3B. confirmed that inhibited proliferation (42% ± 10% Huh7; 52% 7% Hep3B) by arresting cycle inducing apoptosis both lines....
Phytosterols, which are derived from plants, have various beneficial physiological effects, including anti-hypercholesterolemic, anti-inflammatory, and antifungal activities. The anticancer activities of natural products attracted great attention, being associated with a low risk side effects not inducing antineoplastic resistance. β-sitosterol, phytosterol, has been reported to against fibrosarcoma colon, breast, lung, prostate cancer. However, there no reports its activity ovarian...
Endometriosis is a benign gynecological disease characterized by abnormal growth of endometrial-like cells outside the uterus. Melatonin, hormone secreted pineal gland, has been shown to have therapeutic effects in various diseases, including endometriosis. However, underlying molecular mechanisms are yet be elucidated. The results this study demonstrated that melatonin and dienogest administration effectively reduced surgically induced endometriotic lesions mouse model. Melatonin suppressed...
Expanded polytetrafluoroethylene (ePTFE), also known as Gore-Tex, is widely used an implantable biomaterial in biomedical applications because of its favorable mechanical properties and biochemical inertness. However, infection inflammation are two major complications with ePTFE implantations, pathogenic bacteria can inhabit the microsized pores, without clearance by host immune cells, limited biocompatibility induce foreign body reactions. To minimize these complications, we covalently...
Carvacrol is a monoterpenoid phenol present in the oils of various plants including Origanum vulgare (oregano) or majorana (marjoram). For long time, it has been used as spice foods because its antimicrobial properties. Additionally, appears to have anticancer effects against some cancer but this not well studied. Therefore, we conducted assays confirm carvacrol on choriocarcinoma cell lines (JAR and JEG3). Our results indicate that antiproliferative properties induces apoptosis, resulting...
Brassinin is a phytochemical derived from Chinese cabbage, cruciferous vegetable. has shown anticancer effects on prostate and colon cancer cells, among others. However, its mechanisms hepatocellular carcinoma (HCC) have not been elucidated yet. Our results confirmed that brassinin exerted antiproliferative by reducing proliferating cell nuclear antigen (PCNA) activity, proliferation indicator inducing cycle arrest in human HCC (Huh7 Hep3B) cells. also increased mitochondrial Ca2+ levels...
Alpinumisoflavone is an isoflavonoid extracted from the Cudrania tricuspidate fruit and Genista pichisermolliana. It has various physiological functions, such as anti-inflammation, anti-proliferation, apoptosis, in malignant tumors. However, effect of alpinumisoflavone still not known chronic diseases other benign reproductive diseases, endometriosis. In this study, we examined cell death effects on endometriosis lines, End1/E6E7 VK2/E6E7. Results indicated that inhibited migration...
Silibinin is a flavonolignan extracted from seeds of milk thistles. Traditionally, it has been used as therapeutic agent for liver disorders, and now well‐known its anti‐cancer effects. However, studies on effects silibinin choriocarcinoma are very limited. Therefore, we performed proliferation apoptosis assays to determine the viability human (JAR JEG3) cells. Our results showed that significantly inhibited induced in both JAR JEG3 cells, increased reactive oxygen species (ROS) lipid...
Colon cancer is a disease with high prevalence rate worldwide, and for its treatment, 5-fluorouracil (5-FU)-based chemotherapeutic strategy generally used. However, conventional anticancer agents have some limitations, including the development of drug resistance. Therefore, there has recently been demand improvement antitumor using natural products low side effects efficacy. Polydatin active compound extracted from an annual plant, widely known in diverse types cancer. it still not clearly...
Gossypol, commonly found in cotton seeds, is hazardous to male reproductive physiology. Although several studies have indicated the toxicity of gossypol human and animal reproduction, mechanism action testes has not yet been elucidated. In present study, we investigated effects normal mouse testis cells, TM3 TM4 gossypol-treated C57BL/6 mice. We confirmed antiproliferative using cell viability assays, with PCNA as a proliferation marker, cycle analysis. also verified mitochondrial...
The surface of human silicone breast implants is covalently grafted at a high density with 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymer. Addition cross-linkers essential for enhancing the and mechanical durability MPC graft. graft strongly inhibits not only adsorption but also conformational deformation fibrinogen, resulting in exposure buried amino acid sequence, γ377–395, which recognized by inflammatory cells. Furthermore, numbers adhered macrophages amounts released...
Alpinumisoflavone is a prenylated isoflavonoid derived from the Cudrania tricuspidate fruit and Genista pichisermolliana. has anticancer properties in variety of cancer cells, including colorectal, esophageal, renal hepatocellular carcinoma. However, its mechanisms effects ovarian remain unexplored. Our findings indicate that alpinumisoflavone triggers anti-proliferation 2D- 3D-cultured human (ES2 OV90) reduction proliferating cell nuclear antigen expression sub-G1 phase arrest cycle. Both...