A5027873499- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Minimally Invasive Surgical Techniques
- PARP inhibition in cancer therapy
- Cancer Genomics and Diagnostics
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- Endometriosis Research and Treatment
- Cancer Immunotherapy and Biomarkers
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Renal cell carcinoma treatment
- Immune Cell Function and Interaction
- Management of metastatic bone disease
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Gynecological conditions and treatments
- Colorectal and Anal Carcinomas
- Cancer Diagnosis and Treatment
- RNA Research and Splicing
Yonsei University
2016-2025
Severance Hospital
2010-2025
Keimyung University Dongsan Medical Center
2023
Keimyung University
2023
Ansan University
2023
Korea University
2023
Soonchunhyang University
2023
Korea University Medical Center
2023
Gachon University
2023
Ewha Womans University
2020-2023
Although microRNAs have recently been recognized as riboregulators of gene expression, little is known about microRNA expression profiles in serous ovarian carcinoma. We assessed the and association between prognosis carcinoma.Twenty patients diagnosed with carcinoma eight treated for benign uterine disease December 2000 September 2003 were enrolled this study. The examined using DNA microarray Northern blot analyses.Several differentially expressed compared normal tissues, including miR-21,...
This study examines the relationship between environmental, social, and governance (ESG) factors corporate financial performance. Specifically, we various individual ESG categories, both strengths concerns, aggregate factor their impact on performance including profitability risk. We find a positive effect of profitability, is more pronounced for larger firms. Among different has most significant impact, particularly firms with weak governance. also that variables generally have influence...
The functions of many long non-coding RNAs (lncRNAs) in human cancers remain to be clarified. lncRNA Hox transcript antisense intergenic RNA (HOTAIR) has been reported reprogram chromatin organization and promote breast colorectal cancer metastasis, the involvement lncRNAs cervical is just beginning studied. In present study, we examined expression functional role HOTAIR cancer. was determined tissues (n=111) corresponding normal (n=40) by using real-time polymerase chain reaction, its...
The pathway determining malignant cellular transformation, which depends upon mutation of the BRCA1 tumor suppressor gene, is poorly defined. A growing body evidence suggests that promotion DNA double-strand break repair by homologous recombination (HR) may be means maintains genomic stability, while a role in error-prone nonhomologous (NHR) processes has just begun to elucidated. protein becomes phosphorylated response damage, but effects phosphorylation on recombinational are unknown. In...
// Maria Lee 1, 2, * , Hee Jung Kim 3, Sang Wun 3 Sun-Ae Park Kyung-Hee Chun 4 Nam Hoon Cho 5 Yong Song 1 Young Tae Department of Obstetrics and Gynecology, Seoul National University College Medicine, Seoul, Korea 2 Yonsei Graduate School, Institute Women's Life Medical Science, Biochemistry Molecular Biology, Pathology, These authors have contributed equally to this work Correspondence to: Kim, email: ytkchoi@yuhs.ac Keywords: HOTAIR, long non-coding RNA, invasion, prognosis, cervical...
Abstract Cervical cancer, the fourth most common cancer among women worldwide, often proves fatal and stems from precursor lesions caused by high-risk human papillomavirus (HR-HPV) infection. Accurate early diagnosis is crucial for effective treatment. Current screening methods, such as Pap test, liquid-based cytology (LBC), visual inspection with acetic acid (VIA), HPV DNA testing, have limitations, requiring confirmation through colposcopy. This study introduces CerviCARE AI, an artificial...
Recent research has focused on the impact of long noncoding RNA (lncRNA) in cervical carcinogenesis. However, whether HOXA11 antisense (HOXA11-AS) is involved cancer remains to be elucidated. In present study, we examined HOXA11-AS expression levels patients and determined relationships between clinicopathological factors. We also investigated bio-functional consequences overexpression both vitro vivo. was significantly greater tissues from with than control (P<0.001). Multivariate analysis...
The chemotherapy response score (CRS) system based on histopathological examination has been recently proposed for tubo-ovarian high-grade serous carcinoma (HGSC) to assess neoadjuvant (NAC). This study was aimed at validating the CRS in an external cohort of HGSC patients. included 110 patients who underwent NAC followed by interval debulking surgery. 3-tiered omental and adnexal tissue sections determined 3 independent pathologists. Differences patient outcomes according were analyzed....
Ovarian cancer is a chronic disease with risk of malnutrition. Nutritional Risk Index (NRI) has been reported as simple and accurate tool to assess the nutritional status. We sought explore prevalence malnutrition its association survival in ovarian cancer. A retrospective study was conducted 213 advanced patients. NRI calculated before at end treatment using patients' body weight serum albumin level. Overall (OS) progression-free (PFS) were estimated by Kaplan-Meier method, associations...
Enhancing the radioresponsiveness of colorectal cancer (CRC) is essential for local control and prognosis. However, consequent damage to surrounding healthy cells can lead treatment failure. We hypothesized that short‑chain fatty acids (SCFAs) could act as radiosensitizers cells, allowing administration a lower safer dose radiation. To test this hypothesis, responses three‑dimensional‑cultured organoids, derived from CRC patients, radiotherapy, well effects combined radiotherapy with SCFAs...
Background Responses to immunotherapy vary between different cancer types and sites. Here, we aimed investigate features of exhaustion activation in tumor-infiltrating CD8 T cells at both the primary metastatic sites epithelial ovarian cancer. Methods Tumor tissues peripheral blood were obtained from 65 patients with From these samples, isolated lymphocytes (TILs) mononuclear cells. These used for immunophenotype using multicolor flow cytometry, gene expression profile RNA sequencing ex vivo...
To report preliminary experience of single-port robotic surgery using the da Vinci SP surgical system in gynecologic tumors.This was a retrospective study on 100 consecutive patients who underwent between November 2018 and January 2021. All procedures were performed by an experienced surgeon single 2.5-cm umbilical incision.Of cases, included myomectomy (n=76), hysterectomy (n=2), endometrial cancer staging (n=14), radical (n=3), trachelectomy ovarian cystectomy (n=2). None cases converted...
Objectives: The purpose of this study was to compare the surgical outcomes, complications, and costs between laparoscopic staging laparotomic for early-stage ovarian cancer. Methods: We evaluated 113 patients who underwent laparoscopy (n = 26) or laparotomy 87) staging. retrospectively analyzed patients' demographics operative variables, including time, estimated blood loss, lymph node count, hospital stay, postoperative pain, return normal activity. In addition, groups were also compared....
<i>Aims:</i> To define the learning curve for single-port access (SPA) total laparoscopic hysterectomy (TLH) and evaluate surgical outcomes. <i>Methods:</i> Patient demographics segmental operating times of all 100 patients who underwent SPA-TLH by a single surgeon were analyzed. Patients arranged in order based on surgery date. <i>Results:</i> SPA-TLH. There was no conversion to conventional laparoscopy or laparotomy. The median time until removal...