A5005121876- Traditional Chinese Medicine Analysis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Dermatology and Skin Diseases
- Ginseng Biological Effects and Applications
- Statistical Methods in Clinical Trials
- Blood Pressure and Hypertension Studies
- Natural product bioactivities and synthesis
- Healthcare and Venom Research
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Gene expression and cancer classification
- Diet and metabolism studies
- Phytochemistry and Biological Activities
- Palliative Care and End-of-Life Issues
- Acupuncture Treatment Research Studies
- Psoriasis: Treatment and Pathogenesis
- Mitochondrial Function and Pathology
- Meta-analysis and systematic reviews
- Patient Dignity and Privacy
- Gut microbiota and health
- Tryptophan and brain disorders
- Health Systems, Economic Evaluations, Quality of Life
Massachusetts General Hospital
2022-2025
Harvard University
2022-2025
Dongguk University
2015-2024
Weatherford College
2024
National University Hospital
2023
Dongguk University Ilsan Hospital
2012-2020
Dunsan Korean Medicine Hospital
2019
LIM College
2016
JK Research (United States)
2015
LG (South Korea)
2009
This article introduces a crossover design that is often used in clinical studies, with the advantage of comparing treatment effects within one study subject. In particular, advantages and disadvantages two-period, two-sequence (2 × 2 or AB/BA design), which widely practice, are identified, elements necessary for analysis introduced. explains carryover effect, period sequence period-by-treatment interaction examines commands SAS along example data. After confirming effect using general...
The leaves of Artemisia argyi Lev. et Vant. and A. princeps Pamp. are well known medicinal herbs used to treat patients in China, Japan, Korea with skin problems such as eczema itching, abdominal pain dysmenorrhoea. We investigated the anti-inflammatory effects leaf extract (ALE) using CD mice Raw 264.7 cells. ALE on histopathological changes cytokine production ear tissues were assessed induced by 1-fluoro-2,4-dinitrobenzene (DNFB). Moreover, levels prostaglandin E 2 (PGE ) nitric oxide...
General epidemiological data regarding herpes zoster (HZ) are necessary for treatment and prevention of this disease. In addition, can play an important role in evaluating the efficacy impact vaccination. Though several studies HZ Korea have been conducted, they usually depend on hospital-based may not be representative characteristics all over Korea. The purpose study was to evaluate incidence other features general Korean population. We used population-based medical records from Health...
The aim of this paper is to introduce basic concepts and methods for calculating sample size in animal studies. At the planning stage clinical studies, determination a very important process show validity, accuracy, reliability study. However, not all studies require be calculated. Before conducting study, it essential determine whether study objectives suggest pilot exploratory as well purpose testing hypothesis interest. Since most experiments are would more appropriate review other...
Background and rationale: Glucose is the most important metabolic fuel for brain. Acute hyperglycemia due to cerebral ischemia causes mitochondrial dysfunction slows cell cycle progression, resulting in oxidative stress proliferation inhibition. Glycolysis usually occurs cytoplasm during ischemia. The mechanism of ischemia-induced was investigated. Methods: Both non-fasting young (2-month-old) aged (18-month-old) mice were subjected middle artery occlusion (MCAO) 1, 2 or 3 hours without...
Background/Objectives: This study examined the effects of alcohol consumption on chronic kidney disease (CKD) risk in community-dwelling older adults. Methods: A nationwide retrospective observational was conducted using NHIS-Senior cohort data (2009–2018). Adults aged ≥ 65 years with an estimated glomerular filtration rate (eGFR) 60 mL/min/1.73 m2 were included. Alcohol classified as non-drinking, mild, moderate, or heavy drinking. CKD onset defined eGFR < m2. Results: Of 122,319...
Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white (WG) or red (RG), according processing conditions. In this study, the authors compared efficacies of these two types mouse model acute To produce asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, then challenged OVA. WG RG extracts administered orally. The influences on airway...
Objective . The eradication rate of Helicobacter pylori ( H. ) following standard triple therapy has declined over the past few decades. This study determined whether high dose dual (PPI and amoxicillin) is adequate for eradicating in Korea. Methods was an open-labeled infected treatment-naive patients. Subjects received 14 days: ilaprazole 40 mg tablets given twice a day amoxicillin 750 4 times day. At end therapy, subjects visited clinic to confirm compliance monitor any side effects....
Cabbage, Brassica oleracea var. capitata L., is one of the most common vegetables in world. Because its high levels flavonoids and anthocyanins, cabbage has long been used as a herbal medicine. The antioxidant anti-inflammatory properties were also recently reported.This study was designed to investigate effects mice with contact dermatitis (CD).We investigated methanol extract B. L. (MEBO) on ear swelling, erythema, histopathological changes CD mice. Moreover, cytokine production...
To investigate the alleviation effect of Vaccinium uliginosum extract (DA9301) on tablet computer-induced asthenopia. This was a randomized, placebo-controlled, double-blind and parallel study (Trial registration number: 2013–95). A total 60 volunteers were randomized into DA9301 (n = 30) control groups. The group received oral pill (1000 mg/day) for 4 weeks placebo. Asthenopia evaluated by administering questionnaire containing 10 questions (responses scored scales 0–6; score: 60) regarding...
In traditional Asian medicine, Ligusticum chuanxiong Hort also known as Conioselinum anthriscoides “Chuanxiong”, is mainly used for improving blood circulation or analgesic and anti-inflammatory purposes, but they have a long history of use pain disorders in the head face, such headache. Despite possibility that plant effective diseases cerebral infarction vascular dementia (VaD), mechanism action not well understood. To determine if dried rhizomes L. (Chuanxiong Rhizoma, CR) methanol...
The predictability of brachial-ankle pulse wave velocity (baPWV) for the presence and severity coronary artery disease (CAD) was investigated by measuring baPWV in 501 subjects scheduled angiography. Severity CAD measured using modified Gensini stenosis score (GSS) classified as a vessel (VDS) 0-3. defined diameter stenosis>50%. Subjects were grouped tertile level (<14, 14-17, >17 m/s). with showed higher mean age, prevalence men diabetes, systolic blood pressure. hypertension, use...
We have reported that an extract of Scutellaria baicalensis (ESB) has effects against obesity and hypertriglyceridemia in type 2 diabetic animal model (db/db mouse). In the present study, we tried to explain pharmacological ESB by integrating gene expression information from db/db mouse liver with ESB-treated HepG2 hepatocellular carcinoma cells. Using Connectivity Map (cmap) analysis, found inverse relationship pharmaceutical profiles based on between This two data sets was also observed...
A clinical decision support system (CDSS) is recognized as a technology that enhances efficacy and safety. However, its full potential has not been realized, mainly due to data standards noninteroperable platforms.
Acupuncture is an effective yet complex therapy, integrating syndrome differentiation, selection of appropriate acupoints and skillful needling techniques. Clinicians carefully tailor acupuncture treatment to each patient. However, most clinical trials have been based on a standardized formula points for every patient without properly accounting individualdifferences and, as result, not reflective the true efficacy practice. To determine meridian-based differentiation Sa-am acupuncture, we...
The aim of this study is to report general and age-specific risk factors for pterygium prevalence in the Korean population. This an observational case series study. Data from total 24,812 participants (age 40 years or older) National Health Nutrition Examination Surveys conducted 2010 2012 were retrieved. After applying exclusion criteria, data 13,204 (821 with 12,383 without) used univariate multivariate analyses. General identified grouped by decade: s, 50 60 70 80+. Age-specific...
Licorice is extracted from the roots of plants in Glycyrrhiza genus, especially uralensis China and Korea. It has several pharmacological activities, including neuro-protective, anti-fungal, anti-cariogenic effects. Ischemia/reperfusion-induced brain injury a leading cause adult disability death; thus, identification anti-apoptotic, neuro-protective therapeutic agents viewed as an attractive drug development strategy. Infarct volumes expression apoptosis-related proteins, Bcl-xL, Bcl-2,...
Obesity is known to be influenced by a number of genes, including the β3 subunit G protein (GNB3), β3-adrenergic receptor (ADRB3), uncoupling 2 (UCP2), and peroxisome proliferator activated gamma (PPARγ). The single nucleotide polymorphisms (SNPs) above such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, PPARγ-Pro12Ala, are associated with obesity body mass index. present study evaluates impact Bofutsushosan, traditional Eastern Asian herbal medicine anti-obesity properties, on...
Context: Ephedrae Herba (EH), the dried stems and leaves of Ephedra sinica Stapf., E. intermedia Schrenk et C. A. Mey., or equisetina Bge. (Ephedraceae [Ephedra]) is used to treat respiratory diseases. Recently, especially in Republic Korea, EH has also been for weight reduction.Objective: We evaluated effects molecular targets methanol extract (EHM) on high-fat diet (HFD)-induced hyperlipidemic ICR mice.Materials methods: EHM was orally administered (100 mg/kg body weight/day) 3 weeks....
In traditional Asian medicine, dried rhizomes of Ligusticum chuanxiong Hort. (Chuanxiong Rhizoma [CR]) have long been used to treat pain disorders that affect the head and face such as headaches. Furthermore, they primarily for blood circulation improvement or an analgesic anti-inflammatory medicine. This study aimed investigate neuroprotective effects a methanol extract CR (CRex) on ischemic stroke in mice caused by middle cerebral artery occlusion (MCAO).