A5023299151- Reproductive tract infections research
- Preterm Birth and Chorioamnionitis
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Urinary Tract Infections Management
- Energy and Environment Impacts
- Pelvic floor disorders treatments
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Aluminum Alloy Microstructure Properties
- Probiotics and Fermented Foods
- BRCA gene mutations in cancer
- Educational Systems and Policies
- Healthcare Education and Workforce Issues
- Gut microbiota and health
- Diet and metabolism studies
- Prenatal Substance Exposure Effects
- Uterine Myomas and Treatments
- Homelessness and Social Issues
- Selenium in Biological Systems
- Ovarian cancer diagnosis and treatment
- Health and Wellbeing Research
- Ectopic Pregnancy Diagnosis and Management
- Pregnancy and preeclampsia studies
- Reproductive Physiology in Livestock
Ewha Womans University Medical Center
2021-2024
Ewha Womans University
2020-2024
Youngsan University
2023
Kyung Hee University Hospital at Gangdong
2023
Korea National Institute of Health
2023
Hanyang University
2006
Vaginal dysbiosis can lead to serious infections in asymptomatic women. Lactobacillus probiotics (LBPs) are being investigated as a promising therapy for reversing vaginal microbiota dysbiosis. This study aimed investigate whether administering LBPs could improve and facilitate the colonization of species 36 women were classified based on Nugent score Low-NS (n = 26) High-NS 10) groups. A combination acidophilus CBT LA1, rhamnosus LR5, reuteri LU4 was administered orally 6 weeks. The found...
Abstract Maternal exposure to fine particulate matter (PM 2.5 ) is associated with adverse pregnancy and neonatal health outcomes. To explore the mechanism, we performed mRNA sequencing of cord blood. From an ongoing prospective cohort, Air Pollution on Pregnancy Outcome (APPO) study, 454 pregnant women from six centers between January 2021 June 2022 were recruited. Individual PM was calculated using a time-weighted average model. In APPO age-matched blood samples High (˃15 ug/m 3 ; n = 10)...
Dysbiotic vaginal microbiota (DVM) disturb the environment, including pH, metabolite, protein, and cytokine profiles. This study investigated impact of DVM on environment in 40 Korean pregnant women identified predictable biomarkers birth outcomes. Cervicovaginal fluid (CVF) samples were collected third trimester using swabs, examined for stored at −80 °C further analysis. The grouped as full-term (FTB, n = 20) preterm (PTB, births. was profiled V1–V9 regions. levels targeted metabolites,...
Prenatal exposure to ambient air pollution is linked a higher risk of unfavorable pregnancy outcomes. However, the association between complications and indoor remains unclear. The Air Pollution on Pregnancy Outcomes research hospital-based prospective cohort created look into effects aerodynamically exposed particulate matter (PM)
An association between the vaginal microbiome and preterm birth has been reported. However, in practice, it is difficult to predict premature using because microbial community varies highly among samples depending on individual, prediction rate very low. The purpose of this study was select markers that improve predictive power through machine learning various microbiota develop a algorithm with better combines clinical information. As multicenter case-control 150 Korean pregnant women 54...
Abstract Ureaplasma and Prevotella infections are well-known bacteria associated with preterm birth. However, the development of metagenome sequencing techniques, it has been found that not all colonizations cause The purpose this study was to determine association between colonization induction birth even in presence Lactobacillus . In matched case–control study, a total 203 pregnant Korean women were selected their cervicovaginal fluid samples collected during mid-pregnancy. microbiome...
Particulate matter 2.5 (PM2.5) is associated with reproductive health and adverse pregnancy outcomes. However, studies evaluating biological markers of PM2.5 are lacking, identifying biomarkers for estimating prenatal exposure to prevent complications essential. Therefore, we aimed explore urine metabolites that easy measure as exposure. In this matched case-control study based on the exposure, 30 high group (>15 μg/m3) low (<15 were selected from air pollution outcome (APPO) cohort study....
The air pollution on pregnancy outcome (APPO) study is a prospective hospital-based cohort designed to investigate the maternal and fetal effects of particulate matter with an aerodynamic below 10 μm (PM10) PM2.5 (below 2.5 μm) exposure. This aims analyze relationship between adverse outcomes find related biomarkers develop management guidelines.About 1,200 pregnant women are recruited for 3 years (from January 2021 December 2023) from seven university hospitals complications outcomes. We...
Maternal nutrition during the critical period of pregnancy increases susceptibility offspring to development diseases later in life. This study aimed analyze metabolite profiles investigate effect maternal diet on changes plasma metabolites and identify correlations with metabolic parameters. Pregnant Sprague-Dawley rats were exposed under- overnutrition compared controls, their fed a standard after birth. Plasma metabolism was profiled at 16 weeks age using liquid chromatography-mass...
Fetal alcohol syndrome (FAS) is a developmental and congenital disorder characterized by neurocognitive impairment, structural defects, growth restriction due to prenatal exposure. The estimated global prevalence of use during pregnancy 9.8%, the FAS in general population 14.6 per 10,000 people. In Korea, 16%, 18-51 women, which higher than prevalence. Women’s consumption rates have increased, especially women childbearing age. This could increase incidence FAS, leading medical expenses...
The predominance of vaginal Lactobacillus species, specifically L. crispatus, is important for pregnancy maintenance, but varies by race. composition the microbiome can affect susceptibility to adverse outcomes. We performed 16S rRNA gene amplicon sequencing on swabs taken from Korean pregnant women. Here, we report transition spp. in samples full-term birth (FTB) collected longitudinally second and third trimesters a cohort study (n = 23) their association with abundance preterm (PTB)...
Particulate matter 2.5 (PM
Preterm birth (PTB) is a social problem that adversely affects not only the survival rate of fetus, but also premature babies and families, so there an urgent need to find accurate biomarkers. We noted among causes, eubiosis vaginal microbial community dysbiosis leads changes in metabolite composition. In this study, short chain fatty acids (SCFAs) representing were derivatized using (N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide, MTBSTFA) targeted analysis was conducted extracted...
Ectopic pregnancy (EP) refers to blastocyst implantation outside the uterine endometrium. EP is major cause of maternal morbidity and mortality. Treatment options include surgery, medical therapy with methotrexate, or expectant management. Methotrexate primary regimen used in cases early, unruptured ectopic pregnancies. Most side effects methotrexate are minor, including nausea, vomiting, abdominal discomfort, photosensitive skin reaction. Serious effects, bone marrow suppression, pulmonary...
We examined the association between exposure to PM2.5, focused on individual level, and metabolic dysfunction during pregnancy. APPO study (Air Pollution Pregnancy Outcome) was a prospective, multicenter, observational cohort conducted from January 2021 March 2023. Individual PM2.5 concentrations were calculated using time-weighted average model. Metabolic pregnancy assessed based modified definition of syndrome its components, accounting for pregnancy-specific criteria. Exposure associated...
This study aimed to demonstrate the use of preoperative magnetic resonance imaging (MRI) findings select optimal surgical technique between single-site (SS) and multi-site (MS) robotic myomectomy based on clinical experience, for preservation fertility.Ninety-eight patients who underwent SS or MS using da Vinci® Si system after undergoing MRI were evaluated retrospectively. The correlation intraoperative postoperative during fertility was analyzed. reproductive outcome investigated when...
Background: With the recent development of next-generation sequencing technology, microbiome in body is being revealed detail. It also possible to describe normal vaginal microenvironment and, more specifically, any changes pregnancy. Moreover, we present hypothesis that a contributing factor preterm birth (PTB).Current Concepts: High estrogen status stimulates maturation and proliferation epithelial cells accumulation glycogen, which promotes lactic acid production maintains environment at...
Preterm birth (PTB) refers to delivery before 37 weeks of gestation. Premature neonates exhibit higher neonatal morbidity and mortality rates than term neonates; therefore, predicting preventing PTB are important. In this study, we investigated the potential using short-chain fatty acid (SCFA) levels, specific vaginal microbiota-derived metabolites, as a biomarker in gas chromatography/mass spectrometry. Cervicovaginal fluid (CVF) was collected from 89 pregnant women (29 cases vs. 60...
Vulvovaginal candidiasis (VVC) is a genital infection caused by Candida albicans (C. albicans). Weissella confusa WIKIM51 (Wilac D001) known to be detected in dandelion kimchi, produce lactic acid, and have an anti−inflammatory ability; however, its diverse antifungal effects not been studied. Here, we investigated the effect of Wilac D001 C. compared Lactobacillus species on vaginal epithelial cells (VECs). To test ability against VECs, adhesion test, pro-inflammatory cytokines (interleukin...
Preterm birth (PTB) refers to delivery before 37 weeks of gestation. Premature neonates exhibit higher neonatal morbidity and mortality rates than term neonates; therefore, it is crucial predict prevent PTB. Advancements enable the prediction prevention PTB using genetic approaches, especially by investigating its correlation with single nucleotide polymorphisms (SNPs). We aimed identify impactive relevant SNPs for via whole-genome sequencing analyses blood 31 pregnant women (n = 13) 18) who...
Objective: To select markers that improve predictive power through machine learning among various vaginal microbiota and develop an excellent prediction algorithm combines clinical information. Design, setting population: A multicenter case-control study with 150 Korean pregnant women. Methods: Cervicovaginal fluid were collected from women during mid-pregnancy. Their demographic profiles, white blood cell count, cervical length recorded, the microbiome profiles of cervicovaginal analyzed....
The structural control of Al-Si alloy, which was not studied among various electromagnetic processing materials, considered applying the alternating current and direct magnetic flux density. main aim present study is to investigate effects vibration on macro microstructure alloy in order develop a new process alloy. When conducted for changing shape primary aluminum, at low frequency (≤ 60Hz), dendrite changed speroidal shape. eutectic silicon, fact that morphological change silicon from...