A5041467617- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Alcohol Consumption and Health Effects
- Diet, Metabolism, and Disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Drug-Induced Hepatotoxicity and Protection
- Liver Diseases and Immunity
- Hepatitis Viruses Studies and Epidemiology
- Pancreatitis Pathology and Treatment
- HIV/AIDS drug development and treatment
- Diet and metabolism studies
- Lipid metabolism and disorders
- Pancreatic and Hepatic Oncology Research
- MicroRNA in disease regulation
- Organ Transplantation Techniques and Outcomes
- Nutrition and Health in Aging
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Nutritional Studies and Diet
- Systemic Sclerosis and Related Diseases
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
Hanyang University Seoul Hospital
2021-2025
Hanyang University
2021-2025
Inje University Sanggye Paik Hospital
2015-2025
Anyang University
2023-2025
Seoul National University Bundang Hospital
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Kaohsiung Medical University
2024
National Sun Yat-sen University
2024
Seoul National University
2023
Hanyang University Medical Center
2021-2023
ABSTRACT Background and Aims This study investigated the long‐term prognosis clinical course of patients who survived for more than 5 years after hepatocellular carcinoma (HCC) diagnosis. Methods retrospective cohort used data from Korean National Health Insurance Service database. A total 35,348 subjects newly diagnosed with HCC between January 2008 December 2010 were followed up until 2018. Results 11,514 (32.6%) diagnosis among HCC. Long‐term survivors (≥ years) had a higher proportion...
In relation to the new umbrella terminology for steatotic liver disease (SLD), we aimed elucidate prevalence, distribution, and clinical characteristics of SLD subgroups in primary care setting.
Steatotic liver disease was suggested as an overarching term encompassing various etiologies of hepatic steatosis. Experts from multinational societies went through the Delphi process, including four rounds surveys, and consented to adopt a new nomenclature definition instead conventional nonalcoholic fatty (NAFLD). This improve understanding patients primary care physicians, with explanation pathophysiology in name disease. Also, it could minimize stigmatization by using histological...
A comprehensive analysis of trends in the incidence hepatocellular carcinoma (HCC) is important for planning public health initiatives. We aimed to analyze HCC South Korea over 10 years and predict year 2028.
Abstract Background & Aims There are several reports on the prevalence of metabolic dysfunction‐associated fatty liver disease (MAFLD). However, advanced hepatic fibrosis in MAFLD is largely unknown. We aimed to evaluate MAFLD. Methods A total 6775 subjects from nationwide 13 health check‐up centres were included this cross‐sectional study. Fatty was evaluated using ultrasonography. Significant (≥F2) and (≥F3) defined by MRE thresholds 3.0 kPa (range: 2.99–3.65 kPa) 3.6 3.4–3.9...
Background & Aim To investigate the prevalence, mortalities, and patient characteristics of Acute-on-chronic liver failure (ACLF) according to AARC (Asian Pacific Association for Study Liver ACLF Research Consortium) European CLIF-C (Chronic Failure definitions. Methods We collected retrospective data 1470 hospitalized patients with chronic disease (CLD) acute deterioration between January 2013 December from 21 university hospitals in Korea. Results Of assessed, prevalence based on...
Sorafenib is the first approved systemic treatment for advanced hepatocellular carcinoma (HCC). However, its clinical utility limited, especially in Asian countries. Several reports have suggested survival benefits of hepatic arterial infusion chemotherapy (HAIC) HCC with main portal vein tumor thrombosis (PVTT). This study aimed to compare efficacy sorafenib-based therapy that HAIC-based PVTT.Advanced patients PVTT treated sorafenib or HAIC between 2008 and 2016 at Korea University Medical...
Abstract Background & Aims The cost‐effectiveness to screen hepatic fibrosis in at‐risk population as recommended by several professional societies has been limited. This study aimed investigate the of this screening strategy expanded recently proposed societies. Methods A combined model decision tree and Markov models was developed compare expected costs, quality‐adjusted life‐years (QALYs) incremental ratio (ICER) between no groups. included liver disease‐related health states...
Mixed lineage kinase domain-like protein (MLKL) serves as a critical mediator in necroptosis, form of regulated cell death linked to various liver diseases. This study aims specifically investigate the role MLKL's adenosine triphosphate (ATP)-binding pocket facilitating necroptosis-independent pathways that may contribute disease progression. By focusing on this mechanism, we seek identify potential therapeutic targets can modulate MLKL activity, offering new strategies for prevention and...
Background/AimsBesifovir (BSV) showed comparable antiviral activity superior safety profiles to tenofovir disoproxil fumarate (TDF) in treatment-naïve chronic hepatitis B (CHB).However, no data are available regarding the efficacy and of BSV patients with CHB who switched from long-term TDF BSV.This study aimed evaluate outcome a 48-week therapy treatment. MethodsIn this non-inferiority trial, 153 treated for ≥48 weeks had virus (HBV) DNA <20 IU/mL were randomized receive either 150 mg or...
Background/Aims Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect progression chronic disease (CLD) or cirrhosis (LC). Variations exist in patient demographics prognostic outcomes AD based on aetiology CLD, encompassing LC. However, limited research has been conducted analyse these discrepancies across aetiologies.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex metabolic disorder with diverse spectrum. This study aimed to classify patients MASLD into molecular subtypes based on the underlying pathophysiology. Methods: We performed high-throughput RNA sequencing 164 tissue samples from healthy controls and MASLD. The clustering was individual genes or pathways that showed high variation across samples. Second, single-sample gene set enrichment analysis....
Given the rise of metabolic diseases, we investigated their long-term impact in chronic hepatitis B (CHB) patients receiving nucleos(t)ide analogue (NA). We analyzed data from CHB who initiated NAs 30 centers (7 countries/regions). balanced patient characteristics with and without disease (diabetes, obesity, dyslipidemia, hypertension) via propensity-score matching (PSM) to evaluate adverse liver events motality. The study included 4,500 (54.6% ≥1 disease). PSM yielded 909 pairs...