A5100379533- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Hepatitis B Virus Studies
- Cellular Mechanics and Interactions
- biodegradable polymer synthesis and properties
- Anesthesia and Pain Management
- Alzheimer's disease research and treatments
- RNA Interference and Gene Delivery
- Drug Transport and Resistance Mechanisms
- Gene expression and cancer classification
- Cell death mechanisms and regulation
- Lipid metabolism and biosynthesis
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Food Quality and Safety Studies
- Diet, Metabolism, and Disease
- Phytochemicals and Antioxidant Activities
- Liver Disease and Transplantation
- Dendrimers and Hyperbranched Polymers
- Anesthesia and Sedative Agents
- Endoplasmic Reticulum Stress and Disease
- Gold and Silver Nanoparticles Synthesis and Applications
- Ginseng Biological Effects and Applications
- Advanced Glycation End Products research
Hanyang University
2007-2025
Seoul National University
2023-2024
Seoul National University Hospital
2024
University of California, San Diego
2024
Inje University
2023
Dong-A University
2012-2022
Pusan National University
2009-2022
University of Pittsburgh
2011-2020
Institute for Basic Science
2019-2020
Dongguk University
2019
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti‐viral activity against influenza virus, adenovirus, coxsackievirus, and human immunodeficiency virus. However, it remains be determined whether curcumin can inhibit replication of hepatitis C virus (HCV). In this study, we showed that decreases HCV gene expression via suppression Akt‐SREBP‐1 activation, not by NF‐κB pathway. The combination IFNα exerted profound inhibitory effects on replication....
High-mobility group box protein 1 (HMGB1), a nonhistone nuclear and cytokine mediator, is implicated in the pathogenesis of rheumatoid arthritis (RA). Extracellular HMGB1 binds to its receptors triggers downstream signal cascade leading perpetuation synovitis local tissue invasion. Here, we investigated novel role regulating hypoxia-inducible factor (HIF)-1α mediate angiogenesis RA synovium. HIF-1α mRNA levels activities synovial fibroblasts from patients were enhanced by HMGB1....
The accumulation of plaques β-amyloid (Aβ) peptides, a hallmark Alzheimer's disease, results from the sequential cleavage amyloid precursor protein (APP) by activation β- and γ-secretases. However, production Aβ can be avoided alternate APP α-and We hypothesized that cilostazol attenuates increasing disintegrin metalloproteinase 10 (ADAM10)/α-secretase activity via SIRT1-coupled retinoic acid receptor-β (RARβ) in N2a cells expressing human Swedish mutation (N2aSwe). To evoke endogenous...
Purpose:Our study provides epidemiologic data on the prevalence of refractive errors in all age group ≥5 years Korea.Methods: In 2008 to 2012, a total 33,355 participants aged underwent ophthalmologic examinations.Using right eye, myopia was defined as spherical equivalent (SE) less than -0.5 or -1.0 diopters (D) subjects 19 and older an SE -0.75 -1.25 D 5 18 according non-cycloplegic refraction.Other were follows: high -6.0 D; hyperopia larger +0.5 astigmatism cylindrical error D. The risk...
Chronic hepatitis B is a disease of the liver that can progress to cirrhosis and cancer. The HBx (hepatitis virus X) protein multifunctional regulator induces ER (endoplasmic reticulum) stress by previously unknown mechanisms. plays critical role in inflammatory induction COX2 (cyclo-oxygenase 2) an important mediator this inflammation. In present study, we demonstrate molecular mechanisms on expression. addition, reduced expression enzymes which are involved mitochondrial β-oxidation fatty...
Abstract L ‐Lysine is a potential feedstock for the production of bio‐based precursors engineering plastics. In this study, we developed microbial process high‐level conversion ‐lysine into 5‐aminovalerate (5AVA) that can be used as monomer in nylon 6,5 synthesis. Recombinant Escherichia coli WL3110 strain expressing Pseudomonas putida delta‐aminovaleramidase (DavA) and lysine 2‐monooxygenase (DavB) was grown to high density fed‐batch culture whole cell catalyst. High‐density E. DavAB, an...
A neuroprotective role of autophagy mediates the degradation β-amyloid peptide (Aβ) in Alzheimer's disease (AD). The previous study showed cilostazol modulates by increasing beclin1, Atg5 and LC3-II expressions, depletes intracellular Aβ accumulation. This elucidated mechanisms through which autophagic neurons. In N2a cells, (10-30 μM), significantly increased expression P-AMPKα (Thr 172) downstream P-ACC (acetyl-CoA carboxylase) (Ser 79) as did resveratrol (SIRT1 activator), or AICAR (AMPK...
Mixed lineage kinase domain-like protein (MLKL) serves as a critical mediator in necroptosis, form of regulated cell death linked to various liver diseases. This study aims specifically investigate the role MLKL's adenosine triphosphate (ATP)-binding pocket facilitating necroptosis-independent pathways that may contribute disease progression. By focusing on this mechanism, we seek identify potential therapeutic targets can modulate MLKL activity, offering new strategies for prevention and...
β‐Amyloid (Aβ) deposits and hyperphosphorylated tau aggregates are the chief hallmarks in Alzheimer's disease (AD) brains, but strategies for controlling these pathological events remain elusive. We hypothesized that CK2‐coupled SIRT1 activation stimulated by cilostazol suppresses acetylation (Ac‐tau) phosphorylation (P‐tau) inhibiting of P300 GSK3β. Aβ was endogenously overproduced N2a cells expressing human APP Swedish mutation (N2aSwe) exposure to medium containing 1% fetal bovine serum...
Owing to its high sensitivity and selectivity along with rapid response time, plasmonic detection has gained considerable interest in a wide variety of sensing applications. To improve the fieldwork applicability reliability detection, integration nanoparticles into optical devices is desirable. Herein, we propose an integrated label-free platform comprising cavity that allows sensitive molecular via either surface-enhanced Raman scattering (SERS) or plasmon resonance energy transfer (PRET)....
Autophagy is a vital pathway for the removal of β-amyloid peptide (Aβ) and aggregated proteins that cause Alzheimer's disease (AD). We previously found cilostazol induced SIRT1 expression its activity in neuronal cells, thus, we hypothesized might stimulate clearances Aβ C-terminal APP fragment β subunit (APP-CTFβ) by up-regulating autophagy.When N2a cells were exposed to soluble Aβ1–42, protein levels beclin-1, autophagy-related protein5 (Atg5), decreased significantly. Pretreatment with...
Abstract Injury, surgery, and disease often disrupt tissues it is the process of regeneration that aids restoration architecture function. Regeneration can occur through multiple strategies including stem cell expansion, transdifferentiation, or proliferation differentiated cells. We have identified a case in Xenopus embryonic aggregates restores mucociliated epithelium from mesenchymal Following disruption tissue assembly compact aggregate, first an epithelium, transitioning cells at...
A glucopyranosyl benzyl phthalate, two mannopyranosyl phthalates, and a 2-deoxyglucopyranosyl which were prepared from the corresponding 1-hydroxy sugars hydrogen found to be efficient glycosyl donors in glycosylations of various acceptors using TMSOTf as promoter.
SHP (short heterodimer partner) is an orphan nuclear receptor that plays important role in regulating glucose and lipid metabolism. A variety of transcription factors are known to regulate the PEPCK (phosphoenolpyruvate carboxykinase) gene, which encodes a rate-determining enzyme hepatic gluconeogenesis. Previous reports identified glucocorticoid Foxo1 as novel downstream targets inhibition [Borgius, Steffensen, Gustafsson Treuter (2002) J. Biol. Chem. 277, 49761–49796; Yamagata, Daitoku,...
We report a novel method for H 2 O detection based on single plasmonic nanoprobe via cytochrome c -mediated plasmon resonance energy transfer.
Previous studies have suggested that platelets are associated with inflammation and steatosis may play an important role in liver health. Therefore, we evaluated whether antiplatelet agents can improve metabolic disorder-related fatty disease (MASLD). The mice used the study were fed a high-fat-diet (HFD) stratified through biopsy at 18 weeks. A total of 22 NAFLD activity scores (NAS) ≥ 4 randomly divided into three groups (HFD-only, clopidogrel (CLO; 35 mg/kg/day), ticagrelor (TIC; 40...
Gene expression analyses by probes of hybridization from mRNA to cDNA targets arrayed on membranes or activated glass surfaces have revolutionized the way profiling mega level gene expression. The main remaining problems however are sensitivity detection, reproducibility and data processing. During processing microarray images, especially irregularities spot position shape could generate significant errors: small regions signal spots can be mis-included into background area vice versa. Here...