A5102915527- Systemic Lupus Erythematosus Research
- Inflammatory mediators and NSAID effects
- Osteoarthritis Treatment and Mechanisms
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Histone Deacetylase Inhibitors Research
- Calpain Protease Function and Regulation
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Ocular Diseases and Behçet’s Syndrome
- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
- Viral-associated cancers and disorders
- Lipid metabolism and biosynthesis
- Eicosanoids and Hypertension Pharmacology
- Gout, Hyperuricemia, Uric Acid
- Sirtuins and Resveratrol in Medicine
- Parvovirus B19 Infection Studies
- Cytokine Signaling Pathways and Interactions
- Cell death mechanisms and regulation
- Immune Cell Function and Interaction
- Cerebral Venous Sinus Thrombosis
- Bone Metabolism and Diseases
- Peripheral Neuropathies and Disorders
- Adipose Tissue and Metabolism
Dong-A University
2012-2024
Korea Institute of Science and Technology
2024
Dong-A University Hospital
2012-2019
Hanyang University
2018
Bio-Medical Science (South Korea)
2018
Dong-Eui University
2012
Korea Research Institute of Bioscience and Biotechnology
2012
Zhejiang University
2012
National Cancer Center
2010
Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA). M1 phenotype act as pro-inflammatory mediators synovium, whereas those M2 suppress inflammation and promote tissue repair. SIRT1 is a class 3 histone deacetylase with anti-inflammatory characteristics. However, role played by macrophage polarization has not been determined RA. We investigated whether exerts effects modulating M1/M2 macrophages from RA patients. In present study, activation promoted...
Despite the numerous studies of protein kinase CK2, little progress has been made in understanding its function chondrocyte death. Our previous study first demonstrated that CK2 is involved apoptosis rat articular chondrocytes. Recent have suggested downregulation associated with aging. Thus examining involvement death an urgently required task. We undertook this to examine whether modulates measured activity chondrocytes 6-, 21- and 30-month-old rats. Noticeably, was downregulated advancing...
Abstract Objective To examine whether cilostazol, a selective phosphodiesterase type III inhibitor, protects rat articular chondrocytes against nitric oxide (NO)–induced apoptosis and prevents cartilage destruction in mono‐iodoacetate–induced osteoarthritis (OA) model which inducible synthase (iNOS) is expressed. Methods The NO donor sodium nitroprusside was administered to that had been pretreated with cilostazol. Induction of evaluated by DNA electrophoresis pulsed‐field gel...
Although various stimuli-inducing cell demise are known to alter mitochondrial morphology, it is currently debated whether alteration of morphology per se responsible for apoptosis execution or prevention. This study was undertaken examine the effect histone deacetylase (HDAC) inhibitors on fusion-fission equilibrium. The mechanism underlying HDAC inhibitor-induced examined in cells including primary cultured and untransformed cancer lines treated with seven different inhibitors....
Free fatty acids (FFAs), which are elevated with metabolic syndrome, considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, molecular mechanism by exert lipotoxicity induce remains largely unknown. We here observed that oleate at usual clinical range does not while high pathological ranges exerted through apoptosis in articular chondrocytes. By investigating differential effect...
Nonalcoholic fatty liver disease (NAFLD) is an increasingly studied condition that can progress to end-stage disease. Although NAFLD was first described in 1980, a complete understanding of the mechanism and causes this still lacking. Six-transmembrane protein prostate 2 (STAMP2) plays role integrating inflammatory nutritional signals with metabolism. Our previous study suggested STAMP2 may be suitable target for treating NAFLD. In current study, we performed focused drug-screening found...
Although crystallins are major structural proteins in the lens, α-crystallins perform non-lens functions, and αB-crystallin has been shown to act as an anti-apoptotic mediator various cells. The present study was undertaken examine whether expressed human malignant glioma cells exerts acitivity. In addition, we sought elucidate mechanism underlying any observed function of these Three cell lines, U373MG, U118MG, T98G, were used. We that only U373MG line expresses αB-crystallin, whereas other...
Oil spill accidents have series environmental and economic impacts, increasing the demand for efficient technologies to recover oil from contaminated waters. In this study, a hierarchically structured ratchet surface with superhydrophilicity was presented as novel skimming mechanism recovery of high-viscosity oil, particularly low-sulfur fuel (LSFO), which has recently been used marine in open water environments. The interaction between superhydrophilic provides favorable conditions...
Although alpha (α)B-crystallin is expressed in articular chondrocytes, little known about its role these cells. Protein kinase casein 2 (CK2) inhibition induces chondrocyte death. The present study examines whether αB-crystallin exerts anti-apoptotic activity chondrocytes. Primary rat chondrocytes were isolated from knee joint slices. Cells treated with CK2 inhibitors or without siRNA. To examine the silencing of sensitizes to inhibition-induced apoptosis, we assessed apoptosis by performing...
We report on a 13-year-old female with systemic lupus erythematosus (SLE) who exhibited symptoms of severe migraine and familial moyamoya disease. Cerebral magnetic resonance angiography (MRA) showed stenosis occlusion the bilateral internal carotid arteries associated development collateral circulation (moyamoya vessels). In child, as in this case, headaches cerebral infarction disease are unusual. Few cases SLE have been reported, no previous reports such from Korea. There were evidences...
Left transradial coronary angiography may result in damage of both radial arteries patients who experienced right access. In some patients, the left artery has been used as a graft. We investigated whether graft using access is feasible with bypass surgery to preserve future graft.A total 109 consecutive had undergone underwent via same access.Sixteen (15%) were excluded because presence severely tortuous subclavian artery. Bypass or brachial was completed successfully 90 (97%) out 93...
Abstract Rationale: Dystrophic calcinosis occurs in chronically damaged tissue patients with complicated autoimmune diseases. The therapeutic options are limited, and the treatment response rate is variable. Here, we describe a rare case of dystrophic treated leflunomide patient overlap syndrome. Patient concerns: A 53-year-old woman who was diagnosed overlaps syndrome (systemic sclerosis [SSc] rheumatoid arthritis [RA]), presented to our hospital pain swelling both wrists, underwent...
This retrospective study of 432 patients was conducted between 2000 and 2009 to compare immunosuppressive therapy responses in uveitis accompanied or unaccompanied by rheumatic diseases. We divided into two groups: related unrelated The clinical improvement after treatment measured at the end observation period. Of with uveitis, 33 (7.6%) suffered from associated diseases 399 (92.4%) did not. groups showed similar features, but mean age onset lower disease group (44.06 ± 2.13 years vs. 48.23...