A5050735645- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- Chemokine receptors and signaling
- Cell death mechanisms and regulation
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Heat shock proteins research
- Neuroinflammation and Neurodegeneration Mechanisms
- Peroxisome Proliferator-Activated Receptors
- Viral Infections and Vectors
- NF-κB Signaling Pathways
- Ginger and Zingiberaceae research
- Cell Adhesion Molecules Research
- Pharmacological Effects of Natural Compounds
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Viral gastroenteritis research and epidemiology
- Immunotherapy and Immune Responses
- Animal Virus Infections Studies
- Natural product bioactivities and synthesis
- Protease and Inhibitor Mechanisms
- Traditional and Medicinal Uses of Annonaceae
- Virus-based gene therapy research
Pusan National University
2015-2024
Jeonbuk National University
2023
Korea Research Institute of Bioscience and Biotechnology
2002-2008
University of South Carolina
1996-2003
University of Washington
2000-2001
Chungbuk National University
1991
Toll-like receptor (TLR)-4 signaling promotes cytokine synthesis in vascular smooth muscle cells (VSMC). However, it is unknown how TLR-4 regulates interleukin-6 (IL-6) VSMC. Therefore, the present study investigated cellular factors involved TLR-4-mediated IL-6 VSMC terms of MAPK and transcription elements. Exposure aortic to TLR4-specific lipopolysaccharide (LPS) not only enhanced release but also induced transcript via promoter activation. The activation was attenuated by...
Japanese encephalitis (JE) is major emerging neurologic disease caused by JE virus. To date, the impact of TLR molecules on progression has not been addressed. Here, we determined whether each modulates JE, using several TLR-deficient mouse strains (TLR2, TLR3, TLR4, TLR7, TLR9). Surprisingly, among tested mice there were contrasting results in TLR3−/− and TLR4−/− mice, i.e. highly susceptible to whereas showed enhanced resistance JE. TLR3 ablation induced severe CNS inflammation...
Macrophages are crucially involved in the pathogenesis of rheumatoid arthritis (RA). M1 phenotype act as pro-inflammatory mediators synovium, whereas those M2 suppress inflammation and promote tissue repair. SIRT1 is a class 3 histone deacetylase with anti-inflammatory characteristics. However, role played by macrophage polarization has not been determined RA. We investigated whether exerts effects modulating M1/M2 macrophages from RA patients. In present study, activation promoted...
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessel walls, and their phenotypic modulation is a key cellular event driving vascular remodeling. Although high mobility group box-1 (HMGB1) plays pivotal role inflammatory processes after injuries, importance of links between VSMCs, HMGB1 inflammation has not been clarified. To prove hypothesis that VSMCs might be active players by secreting cytokines, we investigated proinflammatory effects its intermediary signaling...
Dendritic cells (DCs) are potent initiators of T cell-mediated immunity that undergo maturation during viral infections. However, few reports describing the interactions DCs with Japanese encephalitis virus (JEV), which remains most frequent cause acute and epidemic encephalitis, available. In this study, we investigated interaction JEV macrophages. replicated its RNA in both different efficiency, infection macrophages followed classical activation pathway up-regulation tested costimulatory...
The loss of endothelial cells is associated with the accumulation monocytes/macrophages underneath surface arteries, where are prone to mechanical stimulation, such as shear stress. However, impact stimuli on monocytic remains unclear. To assess whether stress affects cell function, we examined expression inflammatory molecules and proteins, whose levels changed following in human THP-1 cells. Shear increased chemokine CCL2, which enhanced migration tumor necrosis factor (TNF)-α interleukin...
Abstract Background Macrophages play a pivotal role in the regulation of Japanese encephalitis (JE), severe neuroinflammation central nervous system (CNS) following infection with JE virus (JEV). are known for their heterogeneity, polarizing into M1 or M2 phenotypes context various immunopathological diseases. A comprehensive understanding macrophage polarization and its relevance to progression holds significant promise advancing control therapeutic strategies. Methods To elucidate NADPH...
The importance of TLR2 and TLR9 in the recognition infection with herpes simplex virus (HSV) HSV-caused diseases has been described, but some discrepancies remain concerning benefits these responses. Moreover, impact TLR2/9 on innate adaptive immune responses within relevant mucosal tissues not elucidated using natural model HSV. Here, we demonstrate that dual is essential to provide resistance against HSV via an intravaginal route. Dual ablation resulted highly enhanced mortality...
c-FLIP is a natural homologue of caspase 8, and may antagonize activation death pathways mediated by FADD. highly expressed in the heart, recent report suggests that protect against certain types myocyte death. The present study was designed to define expression patterns heart.The pattern end-stage human hearts, rat cardiomyocyte grafting models analyzed situ hybridization, immunohistochemistry TUNEL assay. In addition, determine whether Fas-dependent pathway active cardiomyocytes vitro, we...
Pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a potential therapy for the treatment obesity and type 2 diabetes. Bioassay-guided isolation CHCl3 extracts fruits Piper longum nigum (Piperaceae), using an in vitro DGAT inhibitory assay, lead to new alkamide named (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine (2), together with four known alkamides: retrofractamide C (1), pipernonaline (3), piperrolein B (4),...
Japanese encephalitis virus (JEV) is a frequent cause of acute and epidemic viral encephalitis. However, there little information describing the mechanisms by which JEV subverts immune responses that may predispose host to secondary infections. In this study, we found induced subversion CD8(+) T cell in transient manner was closely correlated with multiplication. Subsequently, analysis using TCR-transgenic system revealed cells purified from JEV-infected mice showed impaired responses, naive...
Cross‐presentation is the pathway by which exogenous antigens are routed for presentation MHC class I molecules leading to activation of antiviral CD 8 + T ‐cell responses. However, there little information describing modulation cross‐presentation and impact pathogen‐derived signals associated with J apanese encephalitis virus ( JEV ), one most common causes in humans. In this study, we demonstrate that infection could suppress vivo soluble cell‐associated antigens, thereby generating weak...
The root bark of Dictamnus dasycarpus Turcz. (Dictamni Radicis Cortex) has been widely used to treat skin diseases in Korea, and its anti-inflammatory efficacies were recently reported.The paper aims investigate the inhibitory effects decoction Dictamni Cortex (DDRC) mice with contact dermatitis (CD).We investigated DDRC on lesion characteristics such as crust, scales, incrustation petechiae, erythema melanin indexes, thickness, histopathologic changes, cytokine production...
Molecular mechanisms underlying the decreased number of macrophages and T cells in arteries cholesterol-fed-rabbits following dexamethasone administration are unknown. We investigated possibility that could affect activation monocytic induced by oxygenated derivatives cholesterol (oxysterols) using THP-1 monocyte/macrophage cells. 27-Hydroxycholesterol (27OHChol), an oxysterol elevated with hypercholesterolemia, enhanced production CCL2, known as MCP1, chemokine from monocytes/macrophages...