A5011661948- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiac electrophysiology and arrhythmias
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiac pacing and defibrillation studies
- Phytoestrogen effects and research
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Sarcoma Diagnosis and Treatment
- Aortic aneurysm repair treatments
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Infective Endocarditis Diagnosis and Management
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Hemodynamic Monitoring and Therapy
- Cancer, Lipids, and Metabolism
- Cardiac Arrest and Resuscitation
Dong-A University
2013-2025
Korea Research Institute of Bioscience and Biotechnology
2023-2025
Korea University of Science and Technology
2023-2025
Dong-A University Hospital
2015-2024
Chungnam National University Hospital
2024
Ajou University
2024
University Medical Center
2020
University Hospital and Clinics
2020
Soongsil University
2020
University of Dundee
2016
Despite the presence of genes that apparently encode NAD salvage-specific enzymes in its genome, it has been previously thought Mycobacterium tuberculosis can only synthesize de novo. Transcriptional analysis novo synthesis and putative salvage pathway revealed an up-regulation vivo vitro under conditions hypoxia. [14C]Nicotinamide incorporation assays M. isolated directly from lungs infected mice or macrophages exogenous nicotinamide was very efficient vivo-adapted cells, contrast to cells...
Abstract A new type of nonvolatile ferroelectric poly(vinylidene fluoride‐ co ‐trifluoroethylene) (P(VDF‐TrFE)) memory based on an organic thin‐film transistor (OTFT) with a single crystal tri‐isopropylsilylethynyl pentacene (TIPS‐PEN) as the active layer is developed. bottom‐gate OTFT fabricated thin P(VDF‐TrFE) film gate insulator which one‐dimensional ribbon‐type TIPS‐PEN crystal, grown via solvent‐exchange method, positioned between Au source and drain electrodes. Post‐thermal treatment...
Glucosinolates play important roles in plant defense against herbivores and microbes, as well human nutrition. Some glucosinolate‐derived isothiocyanate nitrile compounds have been clinically proven for their anticarcinogenic activity. To better understand glucosinolate biosynthesis Brassica rapa , we conducted a comparative genomics study with Arabidopsis thaliana identified total 56 putative biosynthetic regulator genes. This established high colinearity the pathway between B. ....
In this study, our aim was to evaluate the angio-vasculogenic properties of human adipose tissue-derived mesenchymal stem cells overexpressing granulocyte chemotactic protein (GCP)-2 (hASCs/GCP-2) and determine possible therapeutic effects in an experimental ischaemic heart model. Quantitative real-time (qRT)–PCR results revealed that hASCs/GCP-2 expressed significantly higher levels pro-angiogenic genes, including vascular endothelial growth factor (VEGF)-A, hepatocyte (HGF), interleukin...
Summary Aim We aimed to compare the effects of fixed‐dose combinations ezetimibe plus rosuvastatin alone in patients with primary hypercholesterolemia, including a subgroup analysis diabetes mellitus (DM) or metabolic syndrome (MetS). Method This multicenter eight‐week randomized double‐blind phase III study evaluated safety and efficacy 10 mg rosuvastatin, compared hypercholesterolemia. Four hundred seven hypercholesterolemia who required lipid‐lowering treatment according ATP guideline...
The species Brassica rapa includes important vegetable and oil crops. It also serves as an excellent model system to study polyploidy-related genome evolution because of its paleohexaploid ancestry close evolutionary relationships with Arabidopsis thaliana other larger genomes. Therefore, sequence will be used accelerate both basic research on applied across the cultivated species.We have determined analyzed B. chromosome A3. We obtained 31.9 Mb sequences, organized into nine contigs, which...
Background: Dual antiplatelet therapy (DAPT) helps prevent ischemic events after coronary stenting but comes with an increased risk of bleeding. Several scores have been proposed for the management patients receiving DAPT, no standardized tool exists purpose. We sought to compare performance new PRECISE-DAPT (Predicting Bleeding Complication in Patients Undergoing Stent Implantation and Subsequent Antiplatelet Therapy), CRUSADE (Can Rapid Risk Stratification Unstable Angina Suppress Adverse...
Hyunmin Chung, Seong Ho Bak, Eunju Shin, Taeho Park, Jinwoo Kim, Hanseul Jeong, Haiyoung Jung, Suk Ran Yoon and Ji-Yoon Noh. Biomolecules & Therapeutics -0001;0:. https://doi.org/10.4062/biomolther.2024.133
Abstract Studies have suggested that low‐dose statin monotherapy may be insufficient for target LDL‐C levels. In this randomized, double‐blind, multicenter phase 3 trial, we evaluated the efficacy of combined ezetimibe and atorvastatin in 222 Korean patients with primary hypercholesterolemia. Participants received either 10‐mg ezetimibe/5‐mg (EZE10/ATV5), (EZE10), 5‐mg (ATV5), or (ATV10). At 8 weeks, EZE10/ATV5 achieved greatest reduction (−44.8%) compared EZE10 (−12.7%, p < 0.0001), ATV5...
Background: Ticagrelor reduced the rate of myocardial infarction and death compared with clopidogrel in patients acute coronary syndrome. However, little is understood about chronic treatment ticagrelor on microvascular dysfunction. The objective this study was to assess impact maintenance system flow comparison clopidogrel. Methods: This a nonblinded, open-label, parallel-group, prospective, randomized controlled trial that enrolled 120 syndrome requiring stent implantation. Patients were...
Abstract: The pill burden of patients with hypertension and dyslipidemia can result in poor medication compliance. This study aimed to evaluate the efficacy safety fixed-dose combination (FDC) therapy olmesartan medoxomil (40 mg) rosuvastatin (20 Korean mild moderate dyslipidemia. multicenter, randomized, double-blind, factorial-design included aged ≥20 years essential Patients were randomly assigned receive FDC mg medoxomil, 20 rosuvastatin), 40 rosuvastatin, or a placebo. percentage change...
The novel antiplatelet agent ticagrelor has been demonstrated to exert a faster and more powerful inhibition of platelet aggregation in comparison clopidogrel coronary artery disease patients. However, dose 90 mg twice daily might not be suitable for patients East Asian ethnicity, fully investigated. aim this study was assess the effects low loading doses (LD, mg) maintenance (MD, daily) (600 LD, 75 MD) healthy Korean volunteers. Twelve subjects were randomized into two groups, receiving...
Background : The aim of this study was to evaluate myocardial function in patients with non-hypertensive metabolic syndrome.Methods: We selected syndrome (n = 42) without evidence hypertension and compared them agematched control individuals 20).All were evaluated by two-dimensional tissue Doppler echocardiography including derived strain rate measurements.Results: There no significant differences between the two groups mitral E A inflow velocities or E/A ratio.However, systolic early...
Individuals with intermediate to high cardiac risk for major noncardiac surgery suffer from perioperative myocardial ischemic injury. The purpose of this study was evaluate the long-term impact postoperative troponin elevation on clinical outcome after surgery.Patients (n = 750) aged ≥ 50 years who underwent were eligible study. Postoperative troponin-I data collected retrospectively and consecutively. primary measure allcause mortality. median follow-up period 1727 days in all...
Background:There is insufficient data on the efficacy of prasugrel and ticagrelor in Korean patients with ST-segment elevation myocardial infarction (STEMI).Methods Results:In current double-blind, prospective pilot study, 39 STEMI undergoing primary percutaneous coronary intervention were randomized to receive 60 mg loading dose (LD) followed by 10 daily maintenance (n=19), or 180 LD 90 twice (n=20). We assessed platelet reactivity VerifyNow Vasodilator-Stimulated Phosphoprotein (VASP)...
PurposeThe objective of this study was to evaluate the efficacy and tolerability a triple combination amlodipine/losartan/rosuvastatin in patients with hypertension hypercholesterolemia.MethodsA randomized, multicenter, double-blind, placebo-controlled conducted. Eligible sitting diastolic blood pressure (SiDBP) >90 mm Hg LDL-C levels <250 mg/dL were screened. After 4-week run-in period therapeutic lifestyle changes losartan potassium 100 mg once daily, who met both criteria (80 ≤ SiDBP <...
Previous studies have shown that ergonovine stress echocardiography (ESE) may be a valuable noninvasive tool for the diagnosis of vasospasm after confirmation no significant fixed stenosis.From May 1999 to January 2002, 52 patients who presented with acute coronary syndrome (ACS) and had normal or near-normal angiograms were enrolled. A 50 microg bolus was given intravenously at 5-min intervals, until positive result observed total dose 350 given. After injection, results found in 25 (48%)...