A5034931849- Coronary Interventions and Diagnostics
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Cardiac Valve Diseases and Treatments
- Lipoproteins and Cardiovascular Health
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Erythropoietin and Anemia Treatment
- Pregnancy and preeclampsia studies
- Aortic aneurysm repair treatments
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Function and Risk Factors
- Inflammatory mediators and NSAID effects
- Cardiovascular Health and Disease Prevention
- Mobile Health and mHealth Applications
- Cancer Risks and Factors
- Hemodynamic Monitoring and Therapy
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular Issues in Pregnancy
- Synthesis of β-Lactam Compounds
Seoul National University Bundang Hospital
2016-2025
Seoul National University
2009-2025
National University College
2019-2025
New Generation University College
2010-2025
ORCID
2024
Asan Medical Center
2024
Weatherford College
2024
Korea University
2021
Yonsei University
2017-2019
Seoul National University Hospital
2007-2017
<b>Background:</b> Clopidogrel is a prodrug requiring metabolism by cytochrome P450 3A (CYP3A) isoenzymes, including CYP3A5, in order to be active. It controversial whether clopidogrel interacts with CYP3A inhibitors. We investigated the influence of <i>CYP3A5</i> polymorphism on drug interaction clopidogrel. <b>Methods:</b> In phase 1 study, we administered 16 healthy volunteers who had non-expressor genotype (*3 allele) and expressor (*1 without pretreatment itraconazole, potent inhibitor....
Left ventricular (LV) thrombus is one of the risk factors for systemic thromboembolism. The aims this study were to compare long-term clinical outcomes LV using current therapeutics, anticoagulation, operative treatment, and antiplatelet agents identify independent predictors thromboembolism.We screened 86,374 patients intracardiac in electronic medical records imaging databases. Records 62 with thrombus, diagnosed between May 2003 November 2011, comprehensively reviewed regarding baseline...
There are limited data from randomized trials to guide a specific follow-up surveillance approach after myocardial revascularization. Whether strategy that includes routine functional testing improves clinical outcomes among high-risk patients who have undergone percutaneous coronary intervention (PCI) is uncertain.
The appropriate follow-up surveillance strategy for patients with acute coronary syndrome (ACS) who have undergone percutaneous intervention (PCI) remains unknown.
<h3>Objective</h3> To evaluate whether the addition of cilostazol to dual antiplatelet therapy (DAT, aspirin plus clopidogrel) can attenuate clopidogrel on-treatment platelet reactivity (OPR) in patients with CYP2C19 loss-of-function (LOF) allele. <h3>Methods</h3> In CILON-T randomised trial, were randomly assigned either DAT or triple (TAT, cilostazol). Genotyping cytochrome P450 *2, *3 and *17 was performed OPR measured using VerifyNow P2Y12 assay. Carriers those at least one LOF...
To examine physiological and clinical relevance of an anomalous right coronary artery originating from left sinus Valsalva (right ACAOS) with interarterial course in adults.For assessment, fractional flow reserve (FFR) during dobutamine challenge was measured 37 consecutive adult patients lone ACAOS course. At baseline, mean FFR 0.91±0.06, declining to 0.89±0.06 upon infusion (p<0.001). Dobutamine stress significant (≤0.8) three (8.1%), two whom were surgically treated. Following surgery,...
It is well known that platelet volume indices are associated with adverse outcomes following percutaneous coronary intervention(PCI). In this study, we investigated the hypothesis whether association between size and clinical result of high residual reactivity after antiplatelet therapy in patients large platelets.Between February 2010 December 2011, a total 462 consecutive artery disease who were scheduled to undergo planned PCI enrolled study. The degree aggregation induced by arachidonic...
Cardiac auscultation is a cost-effective, noninvasive screening tool that can provide information about cardiovascular hemodynamics and disease. However, with advances in imaging laboratory tests, the importance of cardiac less appreciated clinical practice. The widespread use smartphones provides opportunities for nonmedical expert users to perform self-examination before hospital visits.The objective our study was assess feasibility using no add-on devices at prehospital stage.We performed...
Background Coronary artery disease is a global health concern that necessitates treatments, such as percutaneous coronary intervention (PCI) with drug-eluting stents (DES). Recent advancements in biodegradable polymer-coated DES have improved long-term outcomes by reducing neointimal hyperplasia. Superior patients ultrathin-strut sirolimus-eluting Orsiro stent (BP-SES) compared those thick-strut biolimus-eluting BioMatrix (BP-BES) been shown. This study aimed to explore the mechanisms...
Background Considering that most patients with low or no significant risk factors can safely undergo noncardiac surgery without additional cardiac evaluation, and given the excessive evaluations often performed in undergoing intermediate higher surgeries, practical preoperative assessment tools are essential to reduce unnecessary delays for urgent outpatient services manage medical costs more efficiently. Objective This study aimed use Observational Medical Outcomes Partnership Common Data...
Abstract Studies have suggested that low‐dose statin monotherapy may be insufficient for target LDL‐C levels. In this randomized, double‐blind, multicenter phase 3 trial, we evaluated the efficacy of combined ezetimibe and atorvastatin in 222 Korean patients with primary hypercholesterolemia. Participants received either 10‐mg ezetimibe/5‐mg (EZE10/ATV5), (EZE10), 5‐mg (ATV5), or (ATV10). At 8 weeks, EZE10/ATV5 achieved greatest reduction (−44.8%) compared EZE10 (−12.7%, p < 0.0001), ATV5...
The low engraftment rate of stem/progenitor cells infused via the intracoronary route to ischemic myocardium is one most important factors limiting efficacy cell therapy. We investigated concept priming peripheral blood stem enriched by granulocyte colony-stimulating factor mobilization and apheresis ((mob)PBSCs) with angiopoietin-1 (Ang1), enhance into tissue neovasculogenic potential.The expression Tie2, Ang1 receptor, was significantly higher in (mob)PBSCs than naïve mononuclear...