A5033342453- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Cardiac, Anesthesia and Surgical Outcomes
- Infective Endocarditis Diagnosis and Management
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Aortic aneurysm repair treatments
- Lipoproteins and Cardiovascular Health
- Venous Thromboembolism Diagnosis and Management
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Disease and Adiposity
- Health Systems, Economic Evaluations, Quality of Life
- Vascular Procedures and Complications
- Aortic Thrombus and Embolism
- Cardiac Arrhythmias and Treatments
- Advanced X-ray and CT Imaging
- Aortic Disease and Treatment Approaches
- Innovation Policy and R&D
- Cardiac Health and Mental Health
- Mechanical Circulatory Support Devices
Asan Medical Center
2016-2025
Ulsan College
2016-2025
University of Ulsan
2016-2025
Seoul National University Hospital
2009-2024
St. Vincent's Hospital
2024
Seoul St. Mary's Hospital
2016-2024
National University College
2024
Catholic University of Korea
2009-2024
Pulmonary Hypertension Association
2024
Yeouido St. Mary's Hospital
2024
Percutaneous coronary intervention (PCI) is increasingly used to treat unprotected left main artery stenosis, although coronary-artery bypass grafting (CABG) has been considered be the treatment of choice.We randomly assigned patients with stenosis undergo CABG (300 patients) or PCI sirolimus-eluting stents patients). Using a wide margin for noninferiority, we compared groups respect primary composite end point major adverse cardiac cerebrovascular events (death from any cause, myocardial...
Although intravascular ultrasound (IVUS) guidance has been useful in stenting for unprotected left main coronary artery stenosis, its impact on long-term mortality is still unclear.In the MAIN-COMPARE registry, patients with stenosis a hemodynamically stable condition underwent elective under of IVUS (756 patients) or conventional angiography (219 patients). Patients acute myocardial infarction were excluded. The 3-year outcomes between 2 groups primarily compared using propensity-score...
Several studies have compared the treatment effects of coronary stenting and coronary-artery bypass grafting (CABG). However, there are limited data regarding long-term outcomes these two interventions for patients with unprotected left main artery disease.We evaluated 1102 disease who underwent stent implantation 1138 CABG in Korea between January 2000 June 2006. We adverse (death; a composite outcome death, Q-wave myocardial infarction, or stroke; target-vessel revascularization) use...
Most trials comparing percutaneous coronary intervention (PCI) with coronary-artery bypass grafting (CABG) have not made use of second-generation drug-eluting stents.We conducted a randomized noninferiority trial at 27 centers in East Asia. We planned to randomly assign 1776 patients multivessel artery disease PCI everolimus-eluting stents or CABG. The primary end point was composite death, myocardial infarction, target-vessel revascularization 2 years after randomization. Event rates during...
We report findings from optical coherence tomography (OCT) of in-stent neoatherosclerosis as a cause drug-eluting stent (DES) failure.Optical and grayscale virtual histology intravascular ultrasound were performed in 50 patients (30 stable, 20 unstable angina) with DES restenosis lesions intimal hyperplasia >50% area. Median follow-up time was 32.2 months. Overall, 26 (52%) had at least 1 OCT-defined thin-cap fibroatheroma (TCFA)-containing neointima 29 (58%) neointimal rupture. Patients...
<h3>Importance</h3> Little information exists about the anatomical characteristics and clinical relevance of non–infarct-related artery (IRA) disease among patients with ST-segment elevation myocardial infarction (STEMI). <h3>Objectives</h3> To investigate incidence, extent, location obstructive non-IRA compare 30-day mortality according to presence in STEMI. <h3>Design, Setting, Participants</h3> Retrospective study pooled from a convenience sample 8 independent, international, randomized...
Late stent malapposition (LSM) after drug-eluting (DES) implantation has not been evaluated sufficiently in real-world practice.We the incidence, mechanisms, predictors, and long-term prognosis of LSM DES 557 patients (705 native lesions; sirolimus-eluting 538 lesions paclitaxel-eluting 167 lesions) whom intravascular ultrasound was performed at index 6-month follow-up. occurred 82 with 85 (12.1% overall, 95% CI 9.7% to 14.5%, 71 (13.2%) stents 14 [8.4%] stents, P=0.12]; incidence 25.0%...
Background: Procedural results for percutaneous coronary intervention (PCI) in vessels with chronic total occlusion (CTO) have improved recent years, and PCI strategies moved toward more complete revascularization liberal use of CTO-PCI. However, evidence evaluating CTO-PCI is limited to observational studies small clinical trials. Methods: In this open-label, multicenter, randomized, noninferiority trial, PCI-eligible patients were assigned receive either 1 2 strategies: or no the...
The risks and benefits of long-term dual antiplatelet therapy remain unclear.This prospective, multicenter, open-label, randomized comparison trial was conducted in 24 clinical centers Korea. In total, 5045 patients who received drug-eluting stents were free major adverse cardiovascular events bleeding for at least 12 months after stent placement enrolled between July 2007 2011. Patients to receive aspirin alone (n=2514) or clopidogrel plus (n=2531). primary end point a composite death...
Background— We assessed the optimal intravascular ultrasound (IVUS) stent area to predict angiographic in-stent restenosis (ISR) after sirolimus-eluting implantation for unprotected left main coronary artery (LM) disease. Methods and Results— A total of 403 patients treated with single- or 2-stent strategies (crushing T-stent) had immediate poststenting IVUS 9-month follow-up angiography. Poststenting minimal (MSA) was measured in each 4 segments: ostial anterior descending (LAD), circumflex...
Abstract East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y12 receptor inhibitors (e.g., ticagrelor prasugrel) direct oral anticoagulants are commonly used in current daily practice, the unique risk–benefit trade-off Asians has been a topic of emerging interest. In this article, we propose updated evidence future directions treatment
Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid stenosis (AS). Particularly, limited data exist comparing results TAVR new-generation devices versus early-generation devices. This study sought to evaluate for AS early- and The Bicuspid Registry is an international multicenter enrolling consecutive undergoing between April 2005 May 2015. Of 301 patients, 199 (71.1%) were treated (Sapien XT [Edwards Lifesciences...
Background: Owing to the differential propensity for bleeding and ischemic events with response antiplatelet therapy, safety effectiveness of potent P2Y12 inhibitor ticagrelor in East Asian populations remain uncertain. Methods: In this multicenter trial, 800 Korean patients hospitalized acute coronary syndromes or without ST elevation intended invasive management were randomly assigned receive, a 1:1 ratio, (180 mg loading dose, 90 twice daily thereafter) clopidogrel (600 75 thereafter)....
Long-term comparative outcomes after percutaneous coronary intervention (PCI) with drug-eluting stents and coronary-artery bypass grafting (CABG) for left main artery disease are highly debated.In the PRECOMBAT trial (Premier of Randomized Comparison Bypass Surgery versus Angioplasty Using Sirolimus-Eluting Stent in Patients Left Main Coronary Artery Disease), patients unprotected were randomly assigned to undergo PCI sirolimus-eluting (n=300) or CABG 13 hospitals Korea from April 2004...
In patients with coronary in-stent restenosis (ISR) requiring reintervention, it is unclear if the choice of treatment should depend on whether restenotic stent was a bare-metal (BMS) or drug-eluting (DES). This study aimed to assess comparative efficacy and safety 2 most frequently used treatments — angioplasty drug-coated balloon (DCB) repeat stenting DES in BMS-and DES-ISR. The DAEDALUS (Difference Antirestenotic Effectiveness Drug-Eluting Stent Drug-Coated Balloon Angioplasty for...
Intravascular imaging-guided percutaneous coronary intervention (PCI) with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) showed superior clinical outcomes compared angiography-guided PCI. However, the comparative effectiveness of OCT-guided and IVUS-guided PCI regarding is unknown.In this prospective, multicenter, open-label, pragmatic trial, we randomly assigned 2008 patients significant artery lesions undergoing in a 1:1 ratio to undergo either an The primary end...