A5100637363- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Aortic Disease and Treatment Approaches
- Coronary Interventions and Diagnostics
- Congenital Heart Disease Studies
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Acute Myocardial Infarction Research
- Takotsubo Cardiomyopathy and Associated Phenomena
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Heart Rate Variability and Autonomic Control
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Pulmonary Hypertension Research and Treatments
- Coronary Artery Anomalies
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Anesthesia and Neurotoxicity Research
- Cardiovascular and Diving-Related Complications
- Aortic aneurysm repair treatments
- Cardiac, Anesthesia and Surgical Outcomes
Saitama Medical University
2022-2025
Institute of Cardiology
2023
Keio University
2012-2022
Keio University Hospital
2013-2020
Taiwan Agricultural Research Institute Council of Agriculture, Executive Yuan
2017-2018
Hôpital Privé Jacques Cartier
2014-2017
Générale de Santé
2014-2017
Institut Cardiovasculaire Paris Sud
2013-2017
Dokkyo Medical University Saitama Medical Center
1999-2014
St. Marianna University School of Medicine
1993-2011
Transcatheter aortic valve replacement (TAVR) is being increasingly performed in patients with bicuspid stenosis (AS).This study sought to compare the procedural and clinical outcomes versus tricuspid AS from Bicuspid TAVR multicenter registry.Outcomes of 561 4,546 were compared after propensity score matching, assembling 546 pairs similar baseline characteristics. Procedural recorded according Valve Academic Research Consortium-2 criteria.Compared AS, had more frequent conversion surgery...
The semiquantitative Clinical Frailty Scale (CFS) is a simple tool to assess patients' frailty and has been shown correlate with mortality in elderly patients even when evaluated by nongeriatricians. aim of the current study was determine prognostic value CFS who underwent transcatheter aortic valve replacement.We utilized OCEAN (Optimized Catheter Valvular Intervention) Japanese multicenter registry review data 1215 replacement. Patients were categorized into 5 groups based on stages: 1-3,...
Few studies have evaluated the clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with bicuspid stenosis (AS). Particularly, limited data exist comparing results TAVR new-generation devices versus early-generation devices. This study sought to evaluate for AS early- and The Bicuspid Registry is an international multicenter enrolling consecutive undergoing between April 2005 May 2015. Of 301 patients, 199 (71.1%) were treated (Sapien XT [Edwards Lifesciences...
It is well known that obstructive sleep apnoea-(OSA) frequently associated with obesity. In the current study, we investigated correlation between abdominal visceral fat accumulation and presence of OSA in obese subjects.A consecutive series 37 patients (17 men 20 women) primary obesity who were admitted to Second Department Internal Medicine. Osaka University Hospital, Patients designated as those whose apnoea index (number h-1 sleep) was more than 5.The distribution body determined using...
Although several cytokines and neurotrophic factors induce sympathetic neurons to transdifferentiate into cholinergic in vitro, the physiological pathophysiological roles of this remain unknown. During congestive heart failure (CHF), neural tone is upregulated, but there a paradoxical reduction norepinephrine synthesis reuptake cardiac nervous system (SNS). Here we examined whether transdifferentiation can occur SNS rodent models CHF investigated underlying molecular mechanism(s) using...
Background: The occurrence and clinical impact of untreated subclinical leaflet thrombosis beyond 1 year after transcatheter aortic valve replacement still remain unclear. Methods Results: In a multicenter registry, we analyzed data from 485 patients who underwent 4-dimensional multidetector computed tomography posttranscatheter performed to survey hypoattenuated thickening with reduced motion compatible thrombus at median 3 days, 6 months, year, 2 years, years. Incidence, predictors,...
After skeletal muscle injury, neutrophils, monocytes, and macrophages infiltrate the damaged area; this is followed by rapid proliferation of myoblasts derived from stem cells (also called satellite cells). Although it known that inflammation triggers regeneration, underlying molecular mechanisms remain incompletely understood. In study, we show granulocyte colony-stimulating factor (G-CSF) receptor (G-CSFR) expressed in developing somites. G-CSFR G-CSF were mouse embryos during...
Objective— We recently demonstrated that primitive neural crest–derived (NC) cells migrate from the cardiac crest during embryonic development and remain in heart as dormant stem cells, with capacity to differentiate into various cell types, including cardiomyocytes. Here, we examined migration differentiation potential of these on myocardial infarction (MI). Methods Results— obtained double-transgenic mice by crossing protein-0 promoter-Cre Floxed–enhanced green fluorescent protein mice,...
The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate influence pre- post-procedural anemia on incidence especially AKI, TAVI.Data from French national registry were collected in 3,472 who underwent January 2010 December 2012. Of these 2,137 no/mild group, 748 moderate 587 severe group before TAVI. Furthermore, we divided into three groups according measured as hemoglobin (Hb) drop: <2 g/dl (n=1,633, 1),...
This study sought to compare the multislice computed tomography (MSCT) characteristics of bicuspid aortic valves (BAV) and tricuspid (TAV) before after implantation CoreValve (Medtronic, Santa Rosa, California) or Edwards SapienXT (Edwards Lifesciences, Irvine, CA).From March 2009 2013, a total 67 TAVI patients who had both pre- post-procedural MSCT were studied. Eleven underwent in BAV with (n = 6) 5) 56 TAV 38) 18). The group was similar except for higher pre-procedural mean pressure...
Backgrounds To facilitate the learning process of transcatheter aortic valve implantation (TAVI) in Japan, unique supporting systems (e.g., on‐site proctor and web‐based screening systems) have been developed. Nevertheless, little is known about real‐world clinical outcomes after TAVI Japan compared with their European counterparts. Methods From optimized catheter valvular intervention (OCEAN‐TAVI, Japan) Institut Cardiovasculaire Paris Sud (Massy, France) registries, we evaluated a total...
Background: The relationship between hospitalization duration and physical function in patients with chronic kidney disease (CKD) has not been thoroughly investigated. This study aimed to determine whether assessment of one week after can predict the length stay CKD. Methods: A retrospective was conducted on hospitalized CKD who underwent rehabilitation March 2019 2020. Physical evaluated using Short Performance Battery (SPPB), grip strength, Barthel Index analyzed alongside clinical data....
Coronary obstruction (CO) is a rare but serious complication of transcatheter aortic valve implantation (TAVI). There are very limited data regarding CO following TAVI. The aim this study was to evaluate the incidence and outcomes after TAVI identify predictors including type.Between October 2006 March 2015, 1,203 cases were performed in our institution. Of them, 814 whose coronary height measured using computed tomography for screening analyzed study.The Edwards SAPIEN/SAPIEN XT (S/XT) used...