A5001146356- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Cerebrovascular and Carotid Artery Diseases
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Health and Mental Health
- Infective Endocarditis Diagnosis and Management
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Vascular Procedures and Complications
- Cardiac and Coronary Surgery Techniques
- Aortic Disease and Treatment Approaches
- Advanced X-ray and CT Imaging
Amsterdam UMC Location University of Amsterdam
2016-2025
University of Amsterdam
2016-2025
Amsterdam University Medical Centers
2018-2025
Amsterdam University of Applied Sciences
2025
University Medical Center
2025
Catharina Ziekenhuis
2006-2024
Radboud University Nijmegen
2006-2024
Leiden University Medical Center
2023
Netherlands Heart Institute
2018-2023
Amsterdam Neuroscience
2018-2022
Background— Although coronary artery bypass grafting is generally preferred in symptomatic patients with severe, complex multivessel, or left main disease, some present clinical features that make clinically unattractive. Percutaneous intervention hemodynamic support may be feasible for these patients. Currently, there no systematic comparative evaluation of devices this indication. Methods and Results— We randomly assigned 452 3-vessel disease unprotected severely depressed ventricular...
Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role immediate coronary angiography and percutaneous intervention (PCI) in the treatment patients who have been successfully resuscitated after arrest absence ST-segment elevation myocardial infarction (STEMI) remains uncertain.
Percutaneous mechanical circulatory support devices are increasingly used in acute myocardial infarction complicated by cardiogenic shock (AMI-CS), despite limited evidence for their effectiveness. The aim of this study was to evaluate outcomes associated with use the Impella device compared intra-aortic balloon pump (IABP) and medical treatment patients AMI-CS. Data AMI-CS treated at European tertiary care hospitals were collected retrospectively. All underwent early revascularization...
Bioresorbable vascular scaffolds were developed to overcome the shortcomings of drug-eluting stents in percutaneous coronary intervention (PCI). We performed an investigator-initiated, randomized trial compare everolimus-eluting bioresorbable scaffold with metallic stent context routine clinical practice.We randomly assigned 1845 patients undergoing PCI receive either a (924 patients) or (921 patients). The primary end point was target-vessel failure (a composite cardiac death, myocardial...
Angiographic successful reperfusion in acute myocardial infarction has been defined as TIMI 3 flow. However, flow does not always result effective reperfusion. Myocardial blush grade (MBG) is an angiographic measure of perfusion. We hypothesized that optimal by and MBG 2 or 3.In 924 consecutive patients with after angioplasty for infarction, we prospectively studied the value MBG. End points were death, MACE, enzymatic infarct size, residual left ventricular ejection fraction. Follow-up was...
Discordance between fractional flow reserve (FFR) and coronary velocity (CFVR) may reflect important pathophysiology but usually remains unnoticed in clinical practice. We evaluated the physiological basis outcome associated with FFR/CFVR discordance.We studied 157 intermediate stenoses patients, by FFR CFVR April 1997 September 2006 which revascularization was deferred. Long-term follow-up performed to document occurrence of major adverse cardiac events: death, myocardial infarction, or...
Extracorporeal cardiopulmonary resuscitation (CPR) restores perfusion and oxygenation in a patient who does not have spontaneous circulation. The evidence with regard to the effect of extracorporeal CPR on survival favorable neurologic outcome refractory out-of-hospital cardiac arrest is inconclusive.
Acute cardiogenic shock after myocardial infarction is associated with high in-hospital mortality attributable to persisting low-cardiac output. The Impella-EUROSHOCK-registry evaluates the safety and efficacy of Impella-2.5-percutaneous left-ventricular assist device in patients acute infarction.This multicenter registry retrospectively included 120 (63.6±12.2 years; 81.7% male) from receiving temporary circulatory support device. primary end point evaluated at 30 days. secondary analyzed...
We sought to investigate the impact of multivessel disease (MVD) with and without a chronic total occlusion (CTO) in non-infarct-related artery (IRA) on mortality patients ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).In HORIZONS-AMI trial, 3283 PCI, 1524 (46.4%) had single-vessel (SVD), 1477 (45.0%) MVD CTO, 283 (8.6%) CTO non-IRA. Compared SVD non-IRA were significantly less likely achieve post-procedural TIMI 3 flow (P =...
In patients with coronary in-stent restenosis (ISR) requiring reintervention, it is unclear if the choice of treatment should depend on whether restenotic stent was a bare-metal (BMS) or drug-eluting (DES). This study aimed to assess comparative efficacy and safety 2 most frequently used treatments — angioplasty drug-coated balloon (DCB) repeat stenting DES in BMS-and DES-ISR. The DAEDALUS (Difference Antirestenotic Effectiveness Drug-Eluting Stent Drug-Coated Balloon Angioplasty for...
Acute ST-elevation myocardial infarction (STEMI) is caused by sudden occlusive coronary thrombosis, after plaque disruption; however, a considerable time interval between disturbance and the onset of symptoms has been suggested. We therefore studied age intracoronary thrombi, aspirated during angioplasty in patients with acute STEMI.Percutaneous thrombectomy was performed 211 consecutive STEMI within 6 hours anginal symptoms. The material histologically screened on thrombus components,...
Primary ventricular fibrillation (VF) accounts for the majority of deaths during acute phase myocardial infarction. Identification patients at risk primary VF remains very poor.We performed a case-control study in with first ST-elevation infarction (STEMI) to identify independent factors VF. A total 330 survivors (cases) and 372 controls were included; earlier infarcts or signs structural heart disease excluded. Baseline characteristics, including age, gender, drug use, ECG parameters...