A5105180925- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Antiplatelet Therapy and Cardiovascular Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Heart Failure Treatment and Management
- Vascular Procedures and Complications
- Diabetes Management and Research
- Cardiac Health and Mental Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Lipoproteins and Cardiovascular Health
- Radiation Dose and Imaging
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Effects of Exercise
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
Amsterdam UMC Location University of Amsterdam
2011-2024
Maastricht University Medical Centre
2024
Amsterdam University Medical Centers
2019-2024
Zuyderland Medisch Centrum
2023-2024
Maastricht University
2023
University of Amsterdam
2010-2021
Amsterdam Neuroscience
2020
General Department of Preventive Medicine
2015
Södra Älvsborg Hospital
2013
National Academy of Medicine
2013
Introduction Evidence for the current guidelines treatment of patients with chronic total occlusions (CTO) in coronary arteries is limited. In this study we identified all CTO registered Swedish Coronary Angiography and Angioplasty Registry (SCAAR) studied prevalence, patient characteristics decisions Sweden. Methods Results Between January 2005 2012, 276,931 procedures (coronary angiography or percutaneous intervention) were performed 215,836 SCAAR. We who had 100% luminal diameter stenosis...
Abstract Introduction In patients undergoing percutaneous coronary intervention (PCI), personalised medicine is key to the secondary prevention of ischaemic and bleeding events. To provide an extensive overview quality medicine, a consortium in southeastern region Netherlands has created PCI registry: South-East Heart Registry ( Zuid-Oost Nederland Hart Registratie , ZON-HR). Aim visualise improve post-PCI, focussing on elements such as antiplatelet treatment, cholesterol management...
Background During primary percutaneous coronary intervention (PCI), a concurrent chronic total occlusion (CTO) is found in 10% of patients with ST-elevation myocardial infarction (STEMI). Long-term benefits CTO-PCI have been suggested; however, randomised data are lacking. Our aim was to determine mid-term and long-term clinical outcome versus CTO-No PCI STEMI CTO. Methods The Evaluating Xience left ventricular function on occlusiOns afteR (EXPLORE) multicentre trial that included 302 after...
Many clinicians believe that allowing costs to influence clinical decisions is unethical. They are mistaken in this belief, because it cannot be ethical ignore the adverse consequences upon others of you make, which what 9costs9 represent. There are, however, some important issues deciding count, and how count them. But these dilemmas equally strong with respect benefits them, expose ethically untenable assumptions about such widely-used criteria as survival rates. One advantages systematic...
Background— We aim to study the clinical and procedural characteristics associated with higher radiation exposure in patients undergoing percutaneous coronary interventions (PCIs) angiography. Methods Results— Our present included all angiography PCI procedures 5 centers Western part of Sweden, between January 1, 2008, 19, 2012. The data were collected prospectively these Sweden as Swedish Coronary Angiography Angioplasty Registry (SCAAR). A prediction model was made for (dose–area product)...
The Evaluating Xience and left ventricular function in PCI on occlusiOns afteR STEMI (EXPLORE) trial did not show a significant benefit of percutaneous coronary intervention (PCI) the concurrent chronic total occlusion (CTO) ST-segment elevation myocardial infarction (STEMI) patients global (LV) systolic function. However possible treatment effect will be most pronounced CTO territory. Therefore, we aimed to study compared no-CTO recovery regional LV function, particularly Using...
The EXPLORE (Evaluating Xience and Left Ventricular Function in PCI on Occlusions After STEMI) trial was the first only randomized investigating chronic total occlusion (CTO) percutaneous coronary intervention (PCI) early after primary for ST-segment-elevation myocardial infarction, compared with medical therapy CTO. We performed a 10-year follow-up of to investigate long-term safety clinical impact CTO no-CTO PCI.
Abstract Background In the setting of primary percutaneous coronary intervention, patients with a chronic total occlusion in non-infarct related artery were recently identified as high-risk subgroup. It is unclear whether ST-elevation myocardial infarction should undergo additional intervention on top optimal medical therapy shortly after intervention. Possible beneficial effects include reduction adverse left ventricular remodeling and preservation global function improved clinical outcome...
We investigated the impact of preadmission diabetic status on long-term outcome in patients with ST-segment elevation myocardial infarction (STEMI) treated primary percutaneous coronary intervention (PCI), to improve risk stratification.Between 1997 and 2007, 4,402 STEMI were admitted our hospital stratified as having insulin-treated diabetes mellitus (ITDM) (n=176), non-ITDM (NITDM) (n=354) non-DM (n=3,872). Five-year mortality was significantly higher DM compared (29% vs. 18%, p<0.01)....
Mechanical left ventricular (LV) unloading may reduce infarct size when combined with primary percutaneous coronary intervention (PCI) in patients ST-elevation myocardial infarction (STEMI). The Impella LP2.5 is a novel assist device. Although the short-term safety and feasibility of this device have been demonstrated, long-term effects are unknown. purpose current study was to evaluate support on aortic valve ejection fraction (LVEF).In 2006, 10 anterior STEMI received 3-day after PCI....
Early aspirin withdrawal, also known as P2Y12-inhibitor monotherapy, following percutaneous coronary intervention (PCI) for non-ST-segment elevation acute syndrome (NSTE-ACS) can reduce bleeding without a trade-off in efficacy. Still the average daily risk is highest during first months and it remains unclear if be omitted immediately PCI.The LEGACY study an open-label, multicenter randomized controlled trial evaluating safety efficacy of immediate monotherapy versus dual antiplatelet...
Abstract Background Patients with chronic total coronary occlusions (CTO) are at increased risk for poor clinical outcomes. We aimed to determine the incidence of CTO percutaneous intervention (PCI) and identify patients cardiac events in nationwide Netherlands Heart Registration (NHR). Methods included all PCI procedures ≥1 registered NHR from January 2015 December 2018, excluding acute interventions. used multivariable logistic regression baseline characteristics calculate as odds ratios...
Global left ventricular (LV) function is routinely used to assess cardiac function; however, myocardial strain able identify more subtle dysfunction. We aimed determine the recovery and prognostic value of featuring tracking (FT) cardiovascular magnetic resonance (CMR) in ST-segment elevation infarction (STEMI) patients with a concurrent chronic total occlusion (CTO). In randomized EXPLORE trial, there was no significant difference global LV after percutaneous coronary intervention (PCI)...
Objective The impact on cardiac function of collaterals towards a concomitant chronic total coronary occlusion (CTO) in patients with ST-elevation myocardial infarction (STEMI) has not been investigated yet. Therefore, we have evaluated the well-developed compared poorly developed to CTO STEMI. Methods and results In EXPLORE trial, STEMI were randomised either percutaneous intervention (PCI) or no-CTO PCI. Collateral grades scored angiographically using Rentrop grade classification. Left...