A5086947728- Sulfur Compounds in Biology
- Nerve injury and regeneration
- Cancer-related Molecular Pathways
- Neuroscience of respiration and sleep
- Hereditary Neurological Disorders
- RNA Research and Splicing
- Neurogenesis and neuroplasticity mechanisms
- Mitochondrial Function and Pathology
- Pain Mechanisms and Treatments
- Cell death mechanisms and regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Calcium signaling and nucleotide metabolism
- Connexins and lens biology
- Lipid metabolism and disorders
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Alcohol Consumption and Health Effects
- Ubiquitin and proteasome pathways
- Renal Transplantation Outcomes and Treatments
- Computational Drug Discovery Methods
Dong-A University
2015-2025
Pusan National University Hospital
2018-2021
Korea Research Institute of Bioscience and Biotechnology
2012-2013
Sookmyung Women's University
2013
Dong-Eui University
2012
Zhejiang University
2012
Pusan National University
2009
Despite the importance of soybean as a major crop, genome-wide variation and evolution cultivated soybeans are largely unknown. Here, we catalogued genome in an annual population by high-depth resequencing 10 6 wild accessions obtained 3.87 million high-quality single-nucleotide polymorphisms (SNPs) after excluding sites with missing data any accession. Nuclear phylogeny supported single origin for soybeans. We identified 10-fold longer linkage disequilibrium (LD) relative to maize rice....
Fascaplysin is a bioactive compound derived from marine sponges, which have anticancer properties and potential neuroprotective effects mediated by mitigation of oxidative stress-induced neurotoxicity. This study investigated the concentration-dependent fascaplysin in zebrafish models, focusing on embryonic survival, cardiac function, melanocyte formation, peripheral nerve health. Zebrafish embryos were exposed to at concentrations ranging 10 nM 100 μM, developmental parameters assessed. At...
The increased mitochondrial DNA damage leads to altered functional capacities of retinal pigment epithelial (RPE) cells. A previous study showed the autophagy in RPE cells caused by low concentrations rotenone, a selective inhibitor complex I. However, mechanism which regulates cell death is still unclear. In present study, we examined underlying regulation through inhibition We report herein that rotenone induced mitotic catastrophe (MC) further observed an level undergoing MC (RPE-MC...
Hydrogen sulfide (H2 S) functions as a physiological gas transmitter in both normal and pathophysiological cellular events. H2 S is produced from substances by three enzymes: cystathionine β-synthase (CBS), γ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MST). In human tissues, these enzymes are involved tissue-specific biochemical pathways for production. For example, CBS cysteine aminotransferase/MST present the brain, but CSE not. Thus, we examined expression of production-related...
Although various stimuli-inducing cell demise are known to alter mitochondrial morphology, it is currently debated whether alteration of morphology per se responsible for apoptosis execution or prevention. This study was undertaken examine the effect histone deacetylase (HDAC) inhibitors on fusion-fission equilibrium. The mechanism underlying HDAC inhibitor-induced examined in cells including primary cultured and untransformed cancer lines treated with seven different inhibitors....
During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state developmental promyelinating cells. This recharacterized cell guides newly regrowing to destination remyelinates reinnervated axons. dynamics during degeneration is associated with oxidative events. Heme oxygenases (HOs) are involved in degradation heme biliverdin/bilirubin, ferrous iron, carbon monoxide. Overproduction iron by HOs increases reactive oxygen species, which have...
In the present study, we identified a missense mutation (G199V) in KAT-18 cell line established from primary cultures of anaplastic thyroid cancer (ATC). Notably, knockdown this mutant (mt) p53 reduced viability and exerted antitumor activity equivalent to high doses several chemotherapeutic agents. We showed that had an effect via induction apoptosis. further examined underlying mechanism by which mt gains antiapoptotic function cells. Microarray analysis revealed modified expression...
In addition to its well-characterized role in the lens, αB-crystallin performs other functions. Methylglyoxal (MGO) can alter function of basement membrane retinal pigment epithelial (RPE) cells. Thus, if MGO is not efficiently detoxified, it induce adverse reactions RPE this study, we examined mechanisms underlying anti-apoptotic activity human cell line ARPE-19 following treatment using various assays, including nuclear staining, flow cytometry, DNA electrophoresis, pulse field gel western...
Akt/PKB plays a pivotal role in cell proliferation and survival. However, the isotype-specific roles of Akt mitochondrial function have not been fully addressed. In this study, we explored after stable knockdown isoforms EJ human bladder cancer cells. We found that mass was significantly increased Akt1- Akt3-knockdown cells, increase accompanied by an TFAM NRF1. Akt2 did cause similar effect. Interestingly, Akt3 also led to severe structural defects mitochondria, doxorubicin-induced...