A5051035208- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Nitric Oxide and Endothelin Effects
- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Parkinson's Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Nerve injury and regeneration
- Sulfur Compounds in Biology
- Adipose Tissue and Metabolism
- Biochemical effects in animals
- Alzheimer's disease research and treatments
- Flavonoids in Medical Research
- Hereditary Neurological Disorders
- Advanced biosensing and bioanalysis techniques
- Biochemical Analysis and Sensing Techniques
- Regulation of Appetite and Obesity
- RNA Research and Splicing
- Ginger and Zingiberaceae research
- Genetics and Neurodevelopmental Disorders
- Endometriosis Research and Treatment
- Neuropeptides and Animal Physiology
- Ion Channels and Receptors
- Photoreceptor and optogenetics research
- Nanoplatforms for cancer theranostics
Kyung Hee University
2016-2025
Graduate School USA
2020
Jungheinrich (Germany)
2017-2019
Indiana University School of Medicine
2017
Harvard University
2006-2010
Weatherford College
2010
McLean Hospital
2006-2010
Kyung Hee University Medical Center
2008
Kangbuk Samsung Hospital
2000
Sungkyunkwan University
2000
Parkinson's disease (PD), one of the most common neurodegenerative disorders, is characterised by loss dopaminergic neurons in substantia nigra pars compacta (SNpc) to striatum (ST), and involves oxidative stress. Mulberry fruit from Morus alba L. (Moraceae) commonly eaten, has long been used traditional oriental medicine. It contains well-known antioxidant agents such as anthocyanins. The present study examined protective effects 70 % ethanol extract mulberry (ME) against neurotoxicity...
Abstract Mesenchymal stem cells (MSCs) have been shown to ameliorate a variety of neurological dysfunctions. This effect is believed be mediated by their paracrine functions, since these rarely differentiate into neuronal cells. It clinical interest whether neural induction MSCs beneficial for the replacement therapy diseases. Here we report that expression Neurogenin1 (Ngn1), proneural gene directs differentiation progenitor during development, sufficient convert mesodermal cell fate one....
This study was designed to investigate the anti-inflammatory effects of bee venom (BV) in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model Parkinson's disease (PD).MPTP administered by intraperitoneal (IP) injection at 2-hr intervals over an 8-hr period. Mice were then subjected BV subcutaneous and sacrificed on days 1 3 following final MPTP injection. The loss dopaminergic neurons substantia nigra pars compacta (SNpc) assessed tyrosine hydroxylase (TH)...
Continence and micturition involve urethral closure. Especially, insufficient strength of the pelvic floor muscles including sphincter causes urinary incontinence (UI). Thus, it is most important to understand main mechanism causing UI relationship with sphincter. Functionally anatomically, made up internal external We highlight basic clinical anatomy their meaning. Understanding these relationships may provide a novel view in identifying surgical techniques for UI.
Abstract A major obstacle in luminescence imaging is the limited penetration of visible light into tissues and interference associated with scattering autofluorescence. Near‐infrared (NIR) emitters that can also be excited NIR radiation via two‐photon processes mitigate these factors somewhat because they operate at wavelengths 650–1000 nm where are more transparent, less efficient, endogenous fluorophores likely to absorb. This study presents photolytically stable, photoluminescent, porous...
A fluorescent molecular probe for the identification of glioblastoma is developed. The allows tracing cysteine (Cys) level, which recognized as a new biomarker GBM.
Fascaplysin is a bioactive compound derived from marine sponges, which have anticancer properties and potential neuroprotective effects mediated by mitigation of oxidative stress-induced neurotoxicity. This study investigated the concentration-dependent fascaplysin in zebrafish models, focusing on embryonic survival, cardiac function, melanocyte formation, peripheral nerve health. Zebrafish embryos were exposed to at concentrations ranging 10 nM 100 μM, developmental parameters assessed. At...
Ginger, which has been widely used for dietary condiment, reported to improve memory dysfunction in an animal model of Alzheimer's disease (AD). Recently, a few trials have carried out enhance the effects ginger by improving bioavailability its relevant components via fermentation. Some reports suggested that fermented ability affect AD vitro systems; however, anti-amnesic on vivo still remain be investigated. In present study, we aimed investigate neuroprotective with Schizosaccharomyces...
Astragalus membranaceus (AM) is one of the most popular health-promoting herbs in East Asia, and has been used traditional medicine for more than 2000 years. This study was performed to examine whether AM suppresses atopic dermatitis (AD)-like skin lesions BALB/c mice. Seven-week-old female mice were sensitized with 1-chloro-2,4-dinitrobenzene (DNCB) induce allergic dermatitis. Skin sections stained hematoxylin eosin (H&E) assess epidermal dermal hyperplasia, which determined by measuring...
Hydrogen sulfide (H2 S) functions as a physiological gas transmitter in both normal and pathophysiological cellular events. H2 S is produced from substances by three enzymes: cystathionine β-synthase (CBS), γ-lyase (CSE), 3-mercaptopyruvate sulfurtransferase (MST). In human tissues, these enzymes are involved tissue-specific biochemical pathways for production. For example, CBS cysteine aminotransferase/MST present the brain, but CSE not. Thus, we examined expression of production-related...
Abstract Here, we disclose a new turn‐on type fluorescent probe (named BCB‐1 ) for the detection of Aβ plaques, which is an essential biomarker in Alzheimer's disease (AD). has hybrid structure benzo[ g ]coumarin and benzothiazole, it showed significant emission enhancement at near‐infrared (NIR) region when sensing plaques. also high selectivity sensitivity toward its bio‐imaging applicability was confirmed within AD mouse (5XFAD) brain. We expect our superb diagnosis to be broadly applied...
AP-2 family transcription factors are essential for development and morphogenesis of diverse tissues organs, but their precise roles in specification neural crest stem cell (NCSC)-derived types have not been determined. Among three members known to be expressed the NCSC (i.e. AP-2alpha, AP-2beta, AP-2gamma), we found that only AP-2beta is predominantly sympathetic ganglia developing mouse embryos, supporting its role development. Indeed, null mice significantly reduced levels both...
During Wallerian degeneration, Schwann cells lose their characteristic of myelinating axons and shift into the state developmental promyelinating cells. This recharacterized cell guides newly regrowing to destination remyelinates reinnervated axons. dynamics during degeneration is associated with oxidative events. Heme oxygenases (HOs) are involved in degradation heme biliverdin/bilirubin, ferrous iron, carbon monoxide. Overproduction iron by HOs increases reactive oxygen species, which have...