A5100462881- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- Mast cells and histamine
- Bone health and osteoporosis research
- Inflammation biomarkers and pathways
- Monoclonal and Polyclonal Antibodies Research
- Salivary Gland Disorders and Functions
- Neurogenesis and neuroplasticity mechanisms
- Urticaria and Related Conditions
- Salivary Gland Tumors Diagnosis and Treatment
- Reproductive System and Pregnancy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eosinophilic Disorders and Syndromes
- Bone Metabolism and Diseases
- Glycosylation and Glycoproteins Research
- Food Allergy and Anaphylaxis Research
- Pregnancy and Medication Impact
- Inflammasome and immune disorders
- Polyamine Metabolism and Applications
- Bone health and treatments
- Mesenchymal stem cell research
- Biosimilars and Bioanalytical Methods
- Oral Health Pathology and Treatment
Ajou University
2004-2025
Chonnam National University
2025
Sookmyung Women's University
2023
Goulburn Valley Health
2023
National Institutes of Health
2019-2022
Weatherford College
2022
National Institute of Allergy and Infectious Diseases
2019-2022
Research & Diagnostic Antibodies (United States)
2022
New Generation University College
2021
Seoul National University
2021
Abstract Mesenchymal stem cells (MSCs) have been shown to ameliorate a variety of neurological dysfunctions. This effect is believed be mediated by their paracrine functions, since these rarely differentiate into neuronal cells. It clinical interest whether neural induction MSCs beneficial for the replacement therapy diseases. Here we report that expression Neurogenin1 (Ngn1), proneural gene directs differentiation progenitor during development, sufficient convert mesodermal cell fate one....
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where basal serum (BST) levels >20 ng/mL are minor criterion for diagnosis. Although clonal neoplasms rare, common cause elevated BST genetic trait hereditary α-tryptasemia (HαT) caused by increased germline TPSAB1 copy number. To date, precise structural variation and mechanism(s) underlying HαT general clinical utility genotyping, remain undefined. Through...
Abstract This study aimed to investigate the serum and expression levels of C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, CXCL11, CXC receptor 3 (CXCR3) in minor salivary glands (MSGs) patients with primary Sjögren’s syndrome (pSS), explore their correlations clinical parameters. Serum samples from 49 diagnosed pSS, 33 rheumatoid arthritis (RA), 30 healthy controls (HCs) were collected for measurements CXCL9, CXCR3. Additionally, CXCL MSG tissues measured 41 who underwent biopsy....
Objectives This study aimed to elucidate the potential of serum, urine, and saliva S100 calcium-binding protein A8 (S100A8) levels as biomarkers for systemic lupus erythematosus (SLE). Methods Serum, samples were obtained from 249 patients with SLE Ajou cohort 52 age- sex-matched healthy controls (HCs). The concentrations S100A8 quantified using an ELISA, a receiver operating characteristic curve was used analyze whether they may be diagnosing SLE. Results Among included in our study, mean...
Communication between CD4 T cells and cognate B is key for the former to fully mature into germinal center-T follicular helper (GC-TFH) latter mount a cell-dependent humoral immune response. Although this interaction occurs in B:T synapse-dependent manner, how transcriptionally regulate synapse formation remains largely unknown. Here, we report that Mef2d, an isoform of myocyte enhancer factor 2 (Mef2) transcription family, critical regulator process. In cells, Mef2d negatively regulates...
Objective This study aimed to examine the frequency and risk factors of complications during pregnancy in women with systemic lupus erythematosus (SLE). Methods The medical records patients SLE age-matched controls at Ajou University Hospital were collected. Clinical features compared those controls. Multivariate logistic regression analysis was performed determine predictors adverse maternal fetal outcomes. Results We analyzed 163 pregnancies 596 general population; no significant...
Arterial macrophage cholesterol accumulation and impaired efflux lead to foam cell formation the development of atherosclerosis. Modified lipoproteins interact with toll-like receptors (TLR), causing an increased inflammatory response altered homeostasis. We aimed determine effects TLR antagonists on in human macrophages. Stimulated monocytes were treated (MIP2), transporter expression analyzed. The administration MIP2 attenuated induced by lipopolysaccharides (LPS) oxidized low-density...
Abstract Fibroblastic reticular cells (FRCs) are stromal in secondary lymphoid organs, the major sites for HIV-1 infection of CD4 + T cells. Although FRCs regulate cell survival, proliferation, and migration, whether they play any role spread has not been studied. Here, we show that enhance via trans-infection which capture facilitate come into contact with FRCs. mediate both two- three-dimensional culture systems a manner dependent on virus producer This dependence, was also observed...
Abstract Background While the availability of biological or targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improved outcomes for rheumatoid arthritis (RA) patients, there remains a subset individuals who fail to achieve low disease activity remission despite multiple cycles b/tsDMARDs. This state is referred as 'difficult-to-treat (D2T)' RA. Methods Data from Korean College Rheumatology Biologics registry were utilized analyze patients with RA treated Results...
The stimuli-responsive conformational transformation of peptides possessing a constrained form triggered by specific biological microenvironment would provide an effective strategy for the development highly peptide therapeutics. Here, we developed containing cytotoxic helical KLA sequence with therapeutic specificity through use transformation. is modified to cyclic structure allow helicity that confers low cytotoxicity. electrostatically complexed hyaluronic acid facilitate enhanced...