A5013900334- Food Allergy and Anaphylaxis Research
- Eosinophilic Esophagitis
- Immunodeficiency and Autoimmune Disorders
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- Child Nutrition and Feeding Issues
- Chronic Lymphocytic Leukemia Research
- Pediatric health and respiratory diseases
- Gastrointestinal disorders and treatments
- Celiac Disease Research and Management
- Infant Health and Development
- Platelet Disorders and Treatments
- Child Nutrition and Water Access
- Contact Dermatitis and Allergies
- Blood disorders and treatments
- Blood groups and transfusion
- Mast cells and histamine
- Polyamine Metabolism and Applications
- Cystic Fibrosis Research Advances
- Food Safety and Hygiene
- Viral gastroenteritis research and epidemiology
- Mycobacterium research and diagnosis
- Eosinophilic Disorders and Syndromes
- Cytomegalovirus and herpesvirus research
- Infant Nutrition and Health
Weill Cornell Medicine
2018-2024
Cornell University
2017-2024
Rockefeller University
2024
ENT and Allergy
2023
Nottingham University Hospitals NHS Trust
2022
Presbyterian Hospital
2018-2022
New York Hospital Queens
2018-2022
NewYork–Presbyterian Hospital
2018-2022
New York Proton Center
2012-2020
University of Mississippi Medical Center
2020
Serum tryptase is a biomarker used to aid in the identification of certain myeloid neoplasms, most notably systemic mastocytosis, where basal serum (BST) levels >20 ng/mL are minor criterion for diagnosis. Although clonal neoplasms rare, common cause elevated BST genetic trait hereditary α-tryptasemia (HαT) caused by increased germline TPSAB1 copy number. To date, precise structural variation and mechanism(s) underlying HαT general clinical utility genotyping, remain undefined. Through...
Patients with inherited CARMIL2 or CD28 deficiency have defective T cell signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three isoforms is produced functional across leukocyte subsets. Tested mutant alleles from 89 patients 52 families impair canonical NF-κB not AP-1 NFAT activation in cells stimulated via CD28. Like CD28-deficient patients, CARMIL2-deficient display recalcitrant warts low blood counts CD4+ CD8+ memory TREGs. Unlike...
H Bisgaard, N Li, K Donnelykke. J Allergy Clin Immunol. 2011;128(3):646–652 To investigate the potential association between diversity of neonatal intestinal microbiota and development atopic disorders in childhood. Four hundred eleven infants born Copenhagen to mothers with a history asthma were enrolled from years 1998 2001. Infants had an initial visit at 1 month age subsequently seen for scheduled every 6 months until years. Atopic disease was assessed through examination by doctors...
The authors declare that they have no conflicts of interest
KJ Allen, JJ Koplin, AL Ponsonby. J Allergy Clin Immunol. 2013;131(4):1109–1116, e1–e6 In light of epidemiologic studies that show increased prevalence food allergy in populations who reside farther from the equator, investigators sought to determine association between vitamin D and allergy. From 2007 August 2011, a total 7134 infants 11 15 months age (inclusive) were approached during immunization visits at 120 locations throughout Australia. A 5120 underwent skin-prick testing (SPT)...
R Peters, K Allen, S Dharmage. J Allergy Clin Immunol. 2015;135(5):1257–1266 Using prospectively collected data, this study sought to describe the natural history of peanut allergy in childhood and provide thresholds for skin prick test (SPT) results specific immunoglobulin E (sIgE) levels that predict probability tolerance or persistence allergy. This included 1-year old infants with from population-based, longitudinal HealthNuts conducted Australia. Infants challenge-confirmed ( n =...