A5001178068- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Food Allergy and Anaphylaxis Research
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Urticaria and Related Conditions
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Contact Dermatitis and Allergies
- Pharmaceutical studies and practices
- Allergic Rhinitis and Sensitization
- Erythrocyte Function and Pathophysiology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Autoimmune Bullous Skin Diseases
- Inhalation and Respiratory Drug Delivery
- Vitamin D Research Studies
- Hemoglobinopathies and Related Disorders
- Infant Health and Development
- Iron Metabolism and Disorders
- Immune Cell Function and Interaction
- Methemoglobinemia and Tumor Lysis Syndrome
- Indoor Air Quality and Microbial Exposure
- Genomics and Rare Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Insects and Parasite Interactions
Mersin Üniversitesi
2016-2025
Massachusetts Eye Research and Surgery Institute
2023
Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
2010
Objective: Lung function tests have attracted interest for the diagnosis and follow-up of childhood asthma in recent years. For patients who cannot perform forced expiratory maneuvers, impulse oscillometry (IOS), performed during spontaneous breathing, may be an alternative tool. Methods: Thirty-five acute, 107 stable asthmatic 103 healthy children presented to our clinic IOS followed by spirometry before after salbutamol inhalation. The mean baseline reversibility parameters were compared...
Patients with inherited CARMIL2 or CD28 deficiency have defective T cell signaling, but their immunological and clinical phenotypes remain largely unknown. We show that only one of three isoforms is produced functional across leukocyte subsets. Tested mutant alleles from 89 patients 52 families impair canonical NF-κB not AP-1 NFAT activation in cells stimulated via CD28. Like CD28-deficient patients, CARMIL2-deficient display recalcitrant warts low blood counts CD4+ CD8+ memory TREGs. Unlike...
Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently encountered in daily clinical practice. The aim of this study was determine the confirmation rates, risk factors NSAID hypersensitivity children and try classify them with a standardized diagnostic protocol.All patients suspicion NSAID-induced were evaluated European Network for drug Allergy (ENDA) recommendations. classified as selective responders (SRs) or cross-intolerant (CI) depending on provocation test...
BACKGROUND Recent evidence about the various effects of vitamin D (vit D) on innate and adaptive immunity has led to a search for role vit in asthma. It is postulated that decrease cathelicidin, multifunctional host defense molecule, production due low status may predispose infectious complications children with OBJECTIVE The aim this study was determine association D, D-binding protein (VDBP) cathelicidin acute asthma attacks among allergic METHODS This prospective included 35 patients...
Objective: Transcobalamin II deficiency is a rare autosomal recessive disease characterized by decreased cobalamin availability, which in turn causes accumulation of homocysteine and methylmalonic acid.The presenting clinical features are failure to thrive, diarrhea, megaloblastic anemia, pancytopenia, neurologic abnormalities, also recurrent infections due immune abnormalities early infancy. Materials Methods:Here, we report the laboratory six children with transcobalamin who were all...
There are scarce data about the role of vitamin D (vitD) in asthma control related to seasons and other confounders.To investigate seasonal relationship between vitD levels control, lung function tests (LFTs) cytokines during a 1-year period, among 7-17-year-old asthmatic children.Thirty patients with house dust mite monosensitization were evaluated 3 monthly previous month's health lifestyle factors test (ACT), spirometry bronchial provocation for year. Serum vitD, binding protein (VDBP),...
Pediatric data on the clinical and etiologic features, treatment response, use of omalizumab for chronic urticaria (CU) are quite limited. The aim this study was to evaluate demographic characteristics, laboratory findings, response CU in children. Children with a diagnosis between 2019 2023 were included study. Information tests, provocation tests inducible urticaria, activity scores (UAS7), responses obtained from patients' medical records. A total 150 children (50.7% male) enrolled 14...
Airway hyperresponsiveness (AHR) is a hallmark of asthma. Methacholine challenge test which mostly used to confirm AHR not routinely available. The aim this study was investigate the predictive values fractional exhaled nitric oxide (FeNO), impulse oscillometry (IOS), and plethysmography for assessment in children with well-controlled asthma.60 controlled allergic asthma aged 6-18 years participated study. FeNO measurement, spirometry, IOS, were performed. done assess AHR. PC20 dose response...
Molecular diagnosis of inborn errors immunity (IEI) plays a critical role in determining patients' long-term prognosis, treatment options, and genetic counseling. Over the past decade, broader utilization next-generation sequencing (NGS) techniques both research clinical settings has facilitated evaluation significant proportion patients for gene variants associated with IEI. In addition to its diagnosing known defects, application high-throughput such as targeted, exome, genome led...
Chemotherapeutic drugs can lead to a wide spectrum of cutaneous findings, ranging from nonimmune toxic reactions severe immune-mediated hypersensitivity reactions. The aim this study was evaluate the clinical, histopathological features, and prognosis skin chemotherapeutic compare them with characteristics in children malignancies.
Background and Objectives: Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention pathogenesis SCD. This study aimed to determine distinctive clinical laboratory features role arginine metabolism asthmatic Materials Methods: A total 52 adolescents SCD, including 24 (SCD-A) 28 without (SCD-NA), 40 healthy controls were included. questionnaire, atopy tests, fractional exhaled nitric oxide (FeNO), lung...
Background: Food allergies (FA) are an important public health concern that place a major burden on the lives of children and their families. The complex pathogenesis FAs results in multisystemic heterogenous clinical presentations. Objective: To evaluate, according to immune mechanisms, characteristics risk factors childhood FA Turkey. Methods: This descriptive multicenter study included 1248 with FA, aged < 18 years,, who were evaluated by pediatric allergists 26 different centers....
Ankaferd blood stopper (ABS) is a standardized medicinal plant extract that stimulates the formation of an encapsulated protein network provides focal points for erythrocyte aggregation. It has therapeutic potential to be used management external hemorrhage. Here, authors report infant bleeding from peptic ulcer was stopped successfully by gastroscopic application ABS and other cases topical mucosal bleedings are also presented.
Background: Different recommendations for the classification of nonsteroidal anti-inflammatory drug hypersensitivity reactions (NSHSR) in children have been reported but a shortage still exists. Objective: The aim present study was to evaluate inclusivity two European Academy Allergy and Clinical Immunology (EAACI) position paper classifications characterize factors that underlie discordance children. Methods: Patients with history NSHSR were evaluated standardized diagnostic protocol...
Background: Drug provocation test (DPT) without skin tests is increasingly recommended in the evaluation of children with low-risk beta-lactam (BL) allergies. However, risk definitions are unclear. Objective: The aim this study was to compose a clinical predictive model that could identify at low who safely undergo direct DPT. Methods: data 204 underwent full diagnostic algorithm for suspected BL allergy were analyzed. Clinical used construct mathematical confirmed A prospective new sample...