Abstract Objectives Reference intervals (RIs) play a crucial role in contemporary healthcare by providing critical support for clinical decision-making. RI calculation methods have certain limitations. They cannot capture age-related variations laboratory values and non-linear relations between variables. Therefore, alternative that preserve the continuous type of age consider must be explored. This study aimed to suggest an method, namely, fractional polynomial (FP) regression models,...

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently encountered in daily clinical practice. The aim of this study was determine the confirmation rates, risk factors NSAID hypersensitivity children and try classify them with a standardized diagnostic protocol.All patients suspicion NSAID-induced were evaluated European Network for drug Allergy (ENDA) recommendations. classified as selective responders (SRs) or cross-intolerant (CI) depending on provocation test...

Airway hyperresponsiveness (AHR) is a hallmark of asthma. Methacholine challenge test which mostly used to confirm AHR not routinely available. The aim this study was investigate the predictive values fractional exhaled nitric oxide (FeNO), impulse oscillometry (IOS), and plethysmography for assessment in children with well-controlled asthma.60 controlled allergic asthma aged 6-18 years participated study. FeNO measurement, spirometry, IOS, were performed. done assess AHR. PC20 dose response...

Aims: Down syndrome (DS) is the most common chromosomal abnormality. Many studies have assessed association between maternal gene polymorphisms involved in folate metabolism and risk of having a DS offspring, but data are conflicting. Six folate-metabolizing genes were analayzed to determine possible factors for child be born (DS mothers); these samples taken from 47 Turkish mothers children (case group) 49 control mothers. Investigated include methylenetetrahydrofolate reductase (MTHFR)...

Abstract Background Gestational diabetes mellitus (GDM), which has been identified for the first time during pregnancy and is defined as glucose intolerance of varying degrees, one prediabetes states that are at risk developing type 2 diabetes. MicroRNAs (miRNAs) associated with complications even necessary regulation pancreatic development glucose-induced insulin secretion. This study aims to investigate miRNAs expressed in maternal plasma detect availability a biomarker diagnosis GDM....

Abstract Background To study the effect of levetiracetam in treating Sydenham chorea. Methods We retrospectively collected data 140 patients diagnosed with chorea pediatric neurology and cardiology outpatient clinics Van Training Research Hospital between January 2010 December 2018. Results There were patients, 102 (70%) whom girls, mean age onset 11.8 ± 2.7 years. Symptomatic treatment was initiated all at time diagnosis; this medication changed during follow up 15 patients. The most...

Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare potentially life-threatening hypersensitivity disorders characterized by widespread skin mucosal involvement. However, there is no standardized evidence-based treatment to reduce the complications of SJS/TEN. This article aims compare efficacy different treatments for pediatric SJS/TEN in terms length hospital stay (LOS) using a Bayesian network meta-analysis (NMA). A NMA used combine evidence from...

Background and Objectives: Data on characteristics of asthma in children with sickle cell disease (SCD) is conflicting. Recently, the L-arginine pathway has gained attention pathogenesis SCD. This study aimed to determine distinctive clinical laboratory features role arginine metabolism asthmatic Materials Methods: A total 52 adolescents SCD, including 24 (SCD-A) 28 without (SCD-NA), 40 healthy controls were included. questionnaire, atopy tests, fractional exhaled nitric oxide (FeNO), lung...

Osteoporosis, defined as a systemic skeletal disease, is characterized by increased bone fragility and fracture risk. Studies have shown that dysregulation of the functions miRNAs or mechanisms they mediate may be an important pathological factor in degeneration. Therefore, aim study was to determine role miRNAs, which are thought play metabolism, osteoporosis.

The aim of this study was to determine the alterations walking energy expenditure and plantar pressure distribution in young adults with patellofemoral pain syndrome (PFPS).Thirty five individuals (mean age: 21.31 ± 1.76) PFPS constituted patient group forty healthy participants 21.40 2.11) control group. Preferred speeds (PWS) were determined on over ground. Individuals walked a treadmill for 7 min at their PWS 30% above oxygen consumption recorded via metabolic analyzer. Net calculated...

Background: Drug provocation test (DPT) without skin tests is increasingly recommended in the evaluation of children with low-risk beta-lactam (BL) allergies. However, risk definitions are unclear. Objective: The aim this study was to compose a clinical predictive model that could identify at low who safely undergo direct DPT. Methods: data 204 underwent full diagnostic algorithm for suspected BL allergy were analyzed. Clinical used construct mathematical confirmed A prospective new sample...

Amaç: Bu çalışmada, anatomi dersini, yüz yüze eğitim ve çevrim içi olmak üzere iki farklı şekilde alan hemşirelik ebelik bölümü öğrencilerinin eğitimine ilişkin öngörü deneyimlerini ortaya koymak hedeflendi. Yöntem: Tanımlayıcı nitelikteki bu araştırma Temmuz - Aralık 2020 tarihleri arasında Mersin Üniversitesi Hemşirelik Fakültesi İçel Sağlık Yüksekokulu Ebelik ile Niğde Ömer Halisdemir Zübeyde Hanım Yüksekokulu’nda 699 öğrenci üzerinde gerçekleştirildi. Öğrenciler eğitimini, teorik pratik...

Pulmonary involvement in sickle cell disease (SCD) is a major cause of morbidity and mortality. Recent data about pulmonary function tests children with SCD are conflicting. The objective this study was to determine the abnormalities for first time Turkish young adults by different techniques such as plethysmography impulse oscillometry (IOS). Fifty-eight patients 51 healthy controls were included study. Spirometry, IOS, applied. Lactate dehydrogenase (LDH) level hemolysis marker measured....

Aim: The aim of this study was to investigate the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and unexplained recurrent pregnancy loss (URPL). Materials Methods: This included 70 URPL patients with a history two or more miscarriages healthy multiparous women as control group. KIR genotyping performed in all subjects for KIRs2DL1–4 2DS1–5 genes using polymerase chain reaction sequence-specific primers. Results: There significant relationship genotypes...