A5101564764- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Ocular Surface and Contact Lens
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Diphtheria, Corynebacterium, and Tetanus
- Environmental Toxicology and Ecotoxicology
- Dermatology and Skin Diseases
- Lymphoma Diagnosis and Treatment
- Pluripotent Stem Cells Research
- Proteoglycans and glycosaminoglycans research
- Cancer Immunotherapy and Biomarkers
- Polyamine Metabolism and Applications
- Clostridium difficile and Clostridium perfringens research
- Pancreatic function and diabetes
- Glutathione Transferases and Polymorphisms
- Immunotherapy and Immune Responses
- Receptor Mechanisms and Signaling
- Heat shock proteins research
- Protein Degradation and Inhibitors
- Viral gastroenteritis research and epidemiology
- Bioactive natural compounds
- Plant and Fungal Interactions Research
- Nail Diseases and Treatments
- Medicinal Plants and Bioactive Compounds
Dongguk University Ilsan Hospital
2021-2025
Cell Biotech (South Korea)
2018-2024
Shanghai Cell Therapy Research Institute
2022
Boryung Pharma (South Korea)
2016
Samsung Medical Center
2011-2015
Sungkyunkwan University
2011-2015
Sangmyung University
2011-2015
Green Cross (South Korea)
2013
Ajou University
2009-2012
Biogen (Switzerland)
2012
Oxidative stress is central to the pathology of several neurodegenerative diseases, including multiple sclerosis, and therapeutics designed enhance antioxidant potential could have clinical value. The objective this study was characterize direct neuroprotective effects dimethyl fumarate (DMF) its primary metabolite monomethyl (MMF) on cellular resistance oxidative damage in cultures nervous system (CNS) cells further explore dependence function nuclear factor (erythroid-derived 2)-like 2...
Background: Staphylococcus aureus (SA) has peculiar abilities to colonize the skin in atopic dermatitis (AD) patients.Objective: We sought determine colonization rates of SA acute and chronic lesions AD patients, find any difference according age influences total immunoglobulin E (IgE) eosinophil counts SA.Methods: evaluated IgE level counts, cultured from 687 patients (131 556 lesions) 247 control urticaria (July 2009 November 2010; Samsung Medical Center Dermatology Clinic, Seoul,...
CPEB-mediated translation is important in early development and neuronal synaptic plasticity. Here, we describe a new eukaryotic initiation factor 4E (eIF4E) binding protein, Neuroguidin (Ngd), its interaction with CPEB. In the mammalian nervous system, Ngd detected as puncta axons dendrites growth cones filopodia. contains three motifs that resemble those present eIF4G, 4EBP, Cup, Maskin, all of which are eIF4E proteins. binds directly, must be deleted to abrogate between these two injected...
Members of helix-loop-helix (HLH) protein family Id (inhibitor differentiation) dimerize with bHLH transcription factors and function as negative regulators differentiation during development. Most inhibitory roles proteins have been demonstrated in non-neural tissues, their the developing nervous system are not clearly demonstrated. In this study, we show that Id1, Id2, Id3 increase self-renewing proliferation potential cortical neural stem cells (NSCs) while inhibiting neuronal...
Ex vivo-expanded, allogeneic natural killer (NK) cells can be used for the treatment of various types cancer. In NK cell therapy, from healthy donors must expanded in order to obtain a sufficient number highly purified, activated cells. present study, we established simplified and efficient method large-scale expansion activation under good manufacturing practice (GMP) conditions. After single step magnetic depletion CD3(+) T cells, depleted peripheral blood mononuclear (PBMCs) were...
Allogeneic natural killer (NK) cell therapy is a potential therapeutic approach for variety of solid tumors.We established an expansion method large-scale production highly purified and functionally active NK cells, as well freezing medium the expanded cells.In present study, we assessed effect cryopreservation on cells in regards to viability, phenotype, anti-tumor activity.NK were enormously (about 15,000-fold expansion) with high viability purity by stimulating CD3 + T cell-depleted...
Abstract Ocular surface diseases (OSD) can cause serious visual deterioration and discomfort. Commercial artificial tear solution containing hyaluronic acid (HA) show excellent biocompatibility unique viscoelastic characteristics. Here, we developed a novel HA membrane (HAM) by chemical crosslinking using 1,4-butanediol diglycidyl ether for the effective treatment of OSDs. The main purpose HAMs is to provide sustained release modulate wound healing response in safety efficacy were...
Effective topical drug delivery is crucial for glaucoma treatment, necessitating more convenient methods to enhance patient compliance. This study evaluates the efficacy and safety of using freeze-dried hyaluronic acid (HA) as a carrier novel conjunctival-contact system. We developed HA tablets loaded with latanoprost (HA-latanoprost) verified concentration high-performance liquid chromatography. Twenty mice (C57BL6) were divided into four groups (n = 5 per group): normal saline (group 1),...
Staphylococcus aureus is a well-known microbe that colonizes or infects the skin in atopic dermatitis (AD). The prevalence of methicillin-resistant S. (MRSA) AD has recently been increasing. This study aimed to determine antimicrobial susceptibility patterns lesions and evaluate MRSA Korea. We also recommend proper first-line topical antibiotics for Korean patients with AD. studied aureus-positive swabs (n=583) from lesional infants, children, adults who presented our outpatient clinic July...
CREB mediates the transcriptional effects of glucose and incretin hormones in insulin-target cells insulin-producing β-cells. Although inhibition activity is known to decrease β-cell mass, it still unknown what factors inversely alter signaling pathway Here, we show that dysfunctions occurring chronic hyperglycemia are not caused by simple but rather persistent activation due decreases protein phophatase PP2A. When freshly isolated rat pancreatic islets were chronically exposed 25 mM (high)...
Vitiligo is an acquired disorder characterized by a progressive loss of melanocytes, which difficult to manage and has unknown prognosis. The subtype segmental vitiligo (SV) been established but it not adequately characterized.To collect long-term follow-up data for evaluating the clinical course SV.This study included 87 patients who were diagnosed with SV monitored at clinic. Patients classified into following three groups according disease activity.Among SV, 63.2% had stable disease,...
The prognosis of non-Hodgkin lymphoma (NHL) remains poor, with an unmet need for novel therapies. MG4101, ex vivo-expanded allogeneic natural killer (NK) cell, can enhance rituximab antibody-dependent cytotoxicity in relapsed/refractory (r/r) B cell lymphoma. This study assessed the safety and efficacy MG4101 plus patients r/r NHL. Patients received escalating doses i.v. every 2 weeks. IL-2 was administered s.c. after treatment. Fludarabine cyclophosphamide before treatment cycles 1, 3, 5. A...
The acute administration of dopamine D<sub>1</sub> receptor agonists induces the expression immediate early gene c-<i>fos</i>. In wild type mice, this induction is completely abolished by pretreatment with D<sub>1</sub>-selective antagonist SCH23390, and D<sub>2</sub>-like eticlopride reduces levels c-<i>fos</i> expressed in response to stimulation. Mice deficient for D<sub>3</sub> express agonist-stimulated c-<i>fos</i>immunoreactivity that are lower than their littermates. Moreover,...
Lichen sclerosus et atrophicus (LSA) is an inflammatory disease that primarily causes anogenital lesion in middle aged women.We present here a case of facial LSA with asymptomatic, well-demarcated, whitish to bluish, atrophic patch linear pattern on the forehead 48-year-old woman.This showed atypical clinical presentation and it mimicked en coup de sabre, but histopathologic results confirmed diagnosis LSA.(Ann Dermatol 23(2) 222∼224, 2011)
Introduction Under the hypothesis that early natural killer cell infusion (NKI) following haploidentical stem transplantation (haplo-SCT) will reduce relapse in post-transplant period, we conducted a pilot study to evaluate safety and feasibility of NKI haplo-SCT children with recurrent neuroblastoma who failed previous tandem high-dose chemotherapy autologous SCT. Methods We used 131I-metaiodobenzylguanidine cyclophosphamide/fludarabine/anti-thymocyte globulin regimen for conditioning...
Abstract Intraocular antibiotic delivery is an important technique to prevent bacterial infection after ophthalmic surgery, such as cataract surgery. Conventional drug methods, eye drops, have limitations for intraocular due the intrinsic barrier effect of cornea. Therefore, frequent instillation eyedrops necessary reach a sufficient bactericidal concentration inside eye. In this study, implant, MXF-HA , that combines hyaluronic acid (HA) and moxifloxacin (MXF) was developed increase...
Weltweit nehmen Infektionen durch multiresistente Erreger aus dem Spektrum grampositiver und vermehrt gramnegativer Keime zu. Gleichzeitig stagniert die Entwicklung neuer antibiotischer Substanzen. Darüber hinaus steigt Rate an mit Clostridium difficile sowie vermehrten Resistenzentwicklungen verminderten therapeutischen Möglichkeiten [1]. Diese Entwicklungen erfordern einen rationellen Einsatz von Antibiotika mehr Präventionsmaßnahmen in endoskopischen Abteilungen.