A5069015546- Cytokine Signaling Pathways and Interactions
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Vitamin C and Antioxidants Research
- Nanoplatforms for cancer theranostics
- Auction Theory and Applications
- Whipple's Disease and Interleukins
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- Public-Private Partnership Projects
- Vitamin D Research Studies
- Public Procurement and Policy
- Nanowire Synthesis and Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Supramolecular Self-Assembly in Materials
- Asthma and respiratory diseases
- Respiratory viral infections research
- Prostate Cancer Diagnosis and Treatment
- Environmental Sustainability in Business
- Ga2O3 and related materials
- Silicon Nanostructures and Photoluminescence
- Prostate Cancer Treatment and Research
- Urinary Bladder and Prostate Research
- Immune cells in cancer
- Influenza Virus Research Studies
Seoul National University
2020-2025
Korea Development Institute
2022-2024
National University College
2024
New Generation University College
2024
Seoul National University Hospital
2024
Seoul Institute
2020
Namseoul University
2020
Sogang University
2018
A fluorescent molecular probe for the identification of glioblastoma is developed. The allows tracing cysteine (Cys) level, which recognized as a new biomarker GBM.
Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that expression restricted to non-hematopoietic cells in skin, pancreas, intestine, liver, lung, kidney. Although involved development responses, there been no reports its role brain inflammation. Here, we used RT-PCR, Western blotting, flow cytometry, immunohistochemical, microarray analyses examine brain, using microglial cell line,...
The use of vaccines is the most effective and reliable method for prevention viral infections. However, research on evaluation therapeutic agents in treatment after infection necessary. Zanamivir was administered through inhalation pandemic influenza A/H1N1 2009. emergence drug-resistant strains can occur rapidly. Alloferon, an immunomodulatory drug developed as NK cell activator, exerts antiviral effects against various viruses, particularly viruses. Therefore, alloferon zanamivir were...
Reactive oxygen species (ROS), which are exceptionally high in IBD lesions, known to cause abnormal immune responses inflammatory reactions bowel diseases (IBD) through damage the intestinal mucosal linings. Moreover, they theorized be an agent of development. Vitamin C is widely effective antioxidant for its ability regulate ROS scavenging effect. Therefore, we examined vitamin C's influence on development and progression Gulo(-/-) mice, cannot synthesize like humans due a defect expression...
Glioblastoma (GBM) is one of the most common and fatal primary brain tumors, with a 5-year survival rate 7.2%. The standard treatment for GBM involves surgical resection followed by chemoradiotherapy, temozolomide (TMZ) currently only approved chemotherapeutic agent GBM. However, hydrolytic instability insufficient drug accumulation are major challenges that limit effectiveness TMZ chemotherapy. To overcome these limitations, we have developed delivery platform utilizing porous silicon...
Pancreatic cancer (PCa), one of the most malignant solid tumors, has a high mortality rate. Although there have been many trials chemotherapeutic drugs such as gemcitabine, rates remain significantly higher than for other types cancer. Therefore, more effective ways improving conventional therapy PCa are needed. Cancer cells take up large amounts glutamine to drive their rapid proliferation. Recent studies show that amino acid transporter SLC6A14 is upregulated in some cancers alongside...
Prostate cell proliferation, driven by testosterone, is a major characteristic of benign prostatic hyperplasia (BPH). GV1001, human telomerase reverse transcriptase catalytic subunit, an injectable formulation used as cancer vaccine. It functions penetrating peptide to regulate proliferation. Here, we found that GV1001 effectively suppressed proliferation stromal myofibroblasts (WPMY-1) and epithelial cells (RWPE-1 WPE-NA22) treated with dihydrotestosterone. Also, bound androgen receptors...
Vitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties based on its antioxidative function. Aptamin C, complex of vitamin specific aptamer, has been reported to maintain or even enhance the efficacy while increasing stability. To investigate
Background/Objectives: Vitamin C is a well-known antioxidant with antiviral, anticancer, and anti-inflammatory properties. However, its therapeutic applications are limited by rapid oxidation due to heat light sensitivity. Aptamin C, which employs aptamers bind vitamin has demonstrated enhanced stability efficacy. This study investigates the potential of inhibit progression pulmonary fibrosis, prominent inflammatory lung disease no effective treatment. Methods: Mice bearing bleomycin-induced...
A hybrid composite of silver nanoparticles (AgNPs) and porous silicon microparticles (pSiMPs) was developed applied for the computed tomography (CT) scanning lungs as an image-guided localization agent. We confirmed grafting AgNPs on oxidized pSiMPs template using various analytical equipment, including a electron microscope (SEM), Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), energy-dispersive spectroscopy (EDS). The showed high CT contrast intensity (>1000 HU)...
Atopic dermatitis (AD), a chronic inflammatory skin disease, is characterized by eczemous lesions on the that manifest as severe itching and last long time. AD thought to be response local allergens, including house dust mites (HDMs). Aptamin C modified form of vitamin comprised aptamers (DNA fragments) bind specifically inhibit its oxidation, thereby increasing stability antioxidant effects. It already known shows an anti-inflammatory effect inflammation. Oxidative stress one major causes...
Abstract Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that expression restricted to non-hematopoietic cells in skin, pancreas, intestine, liver, lung, kidney. Although involved development responses, there been no re-ports its role brain inflammation. Here, we used RT-PCR, western blotting, flow cytometry, immunohistochemical, microarray analyses examine brain, using microglial...
Unsolicited proposals (USPs) are permitted in many countries for public–private partnership (PPP) projects. Despite the importance of a competitive and transparent environment throughout tendering process, USPs typically known to have low competition collusive agreements. This study reviews unsolicited road projects implemented through PPPs South Korea, empirically examines relationship between transparency, rules, competition. First, it discovers that weights price (or quantitative)...
Interleukin (IL)-32 is produced by T lymphocytes, natural killer cells, monocytes, and epithelial cells. IL-32 induces the production of pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α, IL-1β, IL-6, IL-8, expression highly increased in rheumatoid arthritis (RA) patients. Enolase-1 (ENO1) a glycolytic enzyme stimulation ENO1 high levels concanavalin A (Con A)-activated peripheral blood mononuclear cells (PBMCs) macrophages RA In addition, there are many reports that anti-ENO1...
<title>Abstract</title> <bold>Background</bold> Trichomoniasis infected with <italic>Trichomonas vaginalis</italic> (<italic>T. vaginalis</italic>), can cause mild symptoms like itching and burning but also lead to more serious adverse outcomes. While typically treated metronidazole, this medication face resistance from <italic>T. some individuals may experience side effects. Hence, the research on effective therapeutic methods is essential improve traditional therapy for...
Abstract Pancreatic cancer frequently metastasizes into one or more organs and tissues located near the pancreas. Metastasis contributes to make curative approach unachievable bring poor prognosis. Therefore, it is important develop a strategy regulate metastasis of pancreatic cancer. Recent research has reported that IL-22 increases factors involved in migration invasion support development The binding receptor exerts its biological effects and, receptors are heterodimer complex composed...
Purpose In many countries that allow unsolicited proposals (USPs) for public–private partnership (PPP) projects, incentives are awarded to the initial proponent of USP projects during tendering process as rewards initially making a proposal. Because such reward system, including bonus USPs commonly known involve fewer tender participants. This paper aims investigate empirical relationship between number participants and institutional factors PPPs. Specifically, two examined: use system...
Abstract Interleukin (IL)-22 is a member of IL-10 family, potent mediator inflammatory responses. It produced by activated CD4+ T cells and natural killer (NK) takes effect on non-hematopoietic mainly stromal epithelial cells. And, IL-22 receptor consists IL-22Rα IL-10Rβ. known that expression restricted to in the skin, pancreas, intestine, liver, lung kidney. Even though involved development responses, but there no report regarding their roles responses brain. In present study, I...
Objectives: The aim of this study was to assess exposure VOCs and PAHs the health effects on volunteers who participated in an oil spill cleanup Yeosu. Methods: Atmospheric were evaluated vicinity accident site questionnaire surveys conducted identify personal characteristics acute symptoms clean-up workers seven days after accident. levels metabolites (t,t-MA, HA, PGA, MA, MHA) (2-NAP, 1-OHP, 2-HF, 1-HPH), oxidative stress markers (TABARS, 8-OHdG) urine analyzed. Their correlation...
Abstract Mucosal damage in inflammatory bowel diseases (IBDs) involves the dysfunctional immunoregulation of gut. Among immunoregulatory factors, oxidative stress is abnormally high level IBDs, and their destructive effects may contribute to initiation or propagation disease. Vitamin C has anti-oxidant, anti-inflammatory immunomodulatory effects. So, we investigated effect vitamin on dextran sulfate sodium (DSS)-induced colitis Gulo(−/−) mice which cannot synthesize C. C-insufficient showed...